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Endocytic Trafficking of the Notch Receptor

  • Björn Schnute
  • Tobias Troost
  • Thomas Klein
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1066)

Abstract

The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation of the Notch receptor. Here, we will focus on its role during receptor degradation and describe the endosomal pathway with the components that are important for Notch degradation and the molecular machinery that orchestrates these events. Subsequently, we will describe the journey of Notch through the endosomal system and discuss the role of the genes involved. Mechanisms of the recently discovered ligand-independent activation of the Notch receptor in the endosomal pathway will be described and its contribution in physiologically Notch-dependent processes will be discussed. Last but not least, we will summarize the evidence for endosomal ligand-independent activation of the Notch pathway in vertebrates.

Keywords

Notch Endocytosis Endosomal trafficking Endosome Lysosome ESCRT Ubiquitination Dx Su(dx) Lgd Shrub CHMP Endosomal maturation Degradation Recycling 

Abbreviations

AAA-ATPase

ATPase Associated with diverse cellular Activities

ADAM10

A Disintegrin and metalloprotease 10

Aki1

Akt Kinase-Interacting Protein 1

ANK

Ankyrin

AP

Adaptor Protein

CADASIL

Cerebral Autosomal Dominant Artheriopathy with Subcortical Infarcts and Leukoencephalopathy

Cbl

Casistas B-lineage lymphoma

CC2D1A

Coiled-Coil and C2 domain-containing protein 1A

CC2D1B

Coiled-Coil and C2 domain-containing protein 1B

CCZ1

Calcium-Caffeine-zinc sensititivity protein

CHMP

Charged multivesicular body protein

COMMD9

COMM (Copper metabolism) domain containing protein 9

CORVET

class C core vacuole/endosome tethering

Crb

Crumbs

CSL

CBF-1, Suppressor of Hairless, LAG-1

Dl

Delta

Dll3

Delta-like 3

DM14

Drosophila melanogaster 14

dNedd4

Neural precursor cell expressed developmentally downregulated protein 4

DSL

(Delta/Serrate/LAG-2)

Dx

Deltex

EE

Early Endosome

EE2A

early endosomal antigene 2

EEVs

Early Endosomal Vesicles

EGF

Epidermal growth factor

ESCRT

Endosomal sorting complex required for transport

FGF

Fibroblast growth factor

Freud-1

FRE under Dual Repression-Binding-Protein 1

Freud-2

FRE under Dual Repression-Binding-Protein 2

FYVE

Fab1 YOTB VAC1 EEA1

GAP

GTPase activating protein

GDF

GTPase dissociation factor

GDI

GDP-dissociation inhibitor

GDP

Guanosine diphosphate

GEF

Guanine nucleotide exchange factor

GFP

Green fluorescent protein

GPI

Glycosylphosphatidylinositol

GTP

Guanosine triphosphate

HOPS

homotypic fusion and protein sorting

Hrs

Hepatocyte growth factor-regulated tyrosine kinase substrate

Hsc70

Heat shock cognate70

ICD

intracellular domain

ILV

intraluminal vesicle

Kuz

Kuzbanian

Lamp

Lysosome-associated membrane glycoprotein

Lgd

Lethal giant discs

LNR

Lin-12 / Notch repeat

ME

Maturing Endosome

Mon1

Monensin sensitivity protein 1

MVB

Multivesicular body

NECD

Notch extracellular domain

NEXT

Notch extracellular truncation

NICD

Notch intracellular domain

NRR

Negative Regulatory Region

PEST

Proline (P), Glutamic acid (E), Serine (S), Threonin(T)

PI(3,5)P2

Phosphatidylinositol 3,5-bisphoshphate

PI3P

Phosphatidylinositol 3-phosphate

Rab

ras-related in brain

RAM

RBPJ-associated molecule

RBPJ

recombination signal binding protein for immunoglobulin kappa J region

RE

Recycling Endosome

RME8

Receptor mediated Endocytosis 8

Ser

Serrate

Shrb

Shrub

SNARE

soluble N-ethylmaleimide-sensitive-factor attachment receptor

SNX

Sorting nexin

Stam

Signal transducing adaptor molecule

Su(Dx)

Suppressor of Deltex

Su(H)

Suppressor of Hairless

TAPE

TBK1-associated Protein in Endolysosomes

TMPs

Transmembrane proteins

Tsg101

tumor susceptibility gene 101

Ub

Ubiquitin

UIM

ubiquitin interacting motif

Vps

Vacoular protein sorting

Notes

Acknowledgments

Work in the Klein lab is supported by the Deutsche Forschungsgemeinschaft (DFG) through SFB 1208 “Identity and Dynamics of Membrane Systems-from Molecules to Cellular Functions “and Sachbeihilfe KL-1028/9-1 and KL-1028/8-1. We apologise to every researchers whose publications are not cited due to restrictions in space.

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of GeneticsHeinrich-Heine-UniversityDuesseldorfGermany

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