Notch and T Cell Function – A Complex Tale

  • Jyothi Vijayaraghavan
  • Barbara A. OsborneEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1066)


Notch drives critical decisions in a multitude of developmental decisions in many invertebrate and vertebrate organisms including flies, worms, fish, mice and humans. Therefore, it is not surprising that Notch family members also play a key role in cell fate choices in the vertebrate immune system. This review highlights the critical function of Notch in the development of mature T lymphocytes from hematopoietic precursors and describes the role of Notch in mature T cell activation, proliferation and differentiation.


Notch T cell CD4+ CD8+ Th1 Th2 Th17 Tregs 



Cytotoxic T lymphocytes.



GSI, γ

Secretase inhibitor


Interferon gamma


Interleukin 17


Interleukin 2


Interleukin 4




Notch intracellular domain


Recombination signal binding protein for immunoglobulin kappa J region


T regulatory cells



The authors thank the members of the Osborne and Minter labs for lively discussions and the National Multiple Sclerosis Society (RG 5151A1/2) and the NIH (CA166009) for support.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Veterinary & Animal Sciences, Program in Animal Biotechnology and Biomedical SciencesUniversity of MassachusettsAmherstUSA
  2. 2.Program in Molecular & Cellular BiologyUniversity of MassachusettsAmherstUSA

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