Colitis pp 141-154 | Cite as

Dysplasia in Inflammatory Bowel Disease

  • Ann DriessenEmail author
  • Karen Paula Geboes
  • Olivier Dewit
  • Anne Jouret-Mourin


Due to the continuous inflamed state of the mucosa, ulcerative colitis and Crohn’s disease patients are at risk of developing colorectal cancer at an earlier age and with a poorer prognosis. Hence continuous endoscopic surveillance with sampling of biopsies is necessary to detect the preneoplastic lesions in an early stage. Recently a new endoscopic classification is published, in which the lesions are categorized into invisible and visible dysplasia, of which the latter is subtyped into polypoid and non-polypoid lesions. Histologically these lesions consist of different types, namely, adenomatous, villous, and the more recently discovered serrated dysplasia. The presence of an inflamed mucosa complicates its diagnosis, resulting in a high interobserver variability in the categories indefinite for dysplasia and low-grade dysplasia. Hence the ECCO guidelines recommend to confirm the diagnosis of dysplasia by an expert pathologist in gastrointestinal pathology.


Dysplasia IBD Dysplasia grading Dysplasia surveillance Flat dysplasia Polypoid dysplasia Non-polypoid dysplasia Serrated dysplasia Villous dysplasia 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ann Driessen
    • 1
    Email author
  • Karen Paula Geboes
    • 2
  • Olivier Dewit
    • 3
  • Anne Jouret-Mourin
    • 4
  1. 1.Department of PathologyUniversity Hospital Antwerp, University of AntwerpAntwerpBelgium
  2. 2.Department of Gastroenterology, Division of Digestive OncologyGhent University HospitalGhentBelgium
  3. 3.Department of GastroenterologyCliniques Universitaires St Luc, UCLBrusselsBelgium
  4. 4.Department of PathologyCliniques Universitaires St Luc, UCLBrusselsBelgium

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