Colitis pp 169-181 | Cite as

Drug-Induced Colon Injury

  • Louis LibbrechtEmail author
  • Anne Jouret-Mourin
  • Karel Geboes


Drug-induced injury of the colon is a relatively frequent though underestimated event. The histological manifestations are very variable and frequently mimic other disease entities with different etiologies. The pathologist should try to give to the clinician indications concerning a possible drug-related etiology of the injury, with a specification of the drug involved, if feasible. Careful clinicopathological confrontation is important to distinguish drug-related injury from other diseases of the colon. The following section provides an overview of the different patterns that can be encountered in drug-induced colon injury, their relation to specific medications, and the possible differential diagnosis.


Colitis Drug-induced Diarrhea Erosions Ulcerations Microscopic colitis Resins IBD-like colitis Ischemic-type colitis Infectious-type colitis Apoptotic colitis Eosinophils Pseudomembranous colitis Mycophenolate mofetil-related colitis Immune checkpoint inhibitor colitis 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Louis Libbrecht
    • 1
    Email author
  • Anne Jouret-Mourin
    • 1
  • Karel Geboes
    • 2
    • 3
  1. 1.Department of PathologyCliniques Universitaires St Luc, UCLBrusselsBelgium
  2. 2.Department of PathologyGhent University HospitalGhentBelgium
  3. 3.Department of PathologyKU LeuvenLeuvenBelgium

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