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Colitis pp 155-167 | Cite as

Treatment-Related Conditions

  • Louis LibbrechtEmail author
  • Maria Leo
  • Karel Geboes
Chapter
First Online:

Abstract

A variety of conditions may develop as an adverse event or within the context of certain types of treatment such as endoscopic and surgical procedures, radio- and chemotherapy, and stem cell or solid organ transplantation. While the histopathological aspect of a colon biopsy or resection may suggest the diagnosis, clinical information is extremely useful because other diseases may mimic treatment-related patterns or the lesions secondary to the treatment may not be specific. This chapter overviews the morphological features and differential diagnosis of these conditions and diseases arising in the setting of certain types of treatment, excluding treatments with non-chemotherapeutic medications/drugs, which are discussed elsewhere in this book.

Keywords

Radiation-induced colitis, acute Radiation-induced colitis, chronic Diversion colitis Graft-versus-host disease (GVHD) Cord colitis Hematopoietic stem cell transplantation Apoptosis Solid organ transplantation Mycophenolate Bacterial infections Viral infections Cytomegalovirus Chemotherapy-related colitis Iatrogenic injury 
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References

  1. 1.
    Willett CG, Ooi CJ, Zietman AL, et al. Acute and late toxicity of patients with inflammatory bowel disease undergoing irradiation for abdominal and pelvic neoplasms. Int J Radiat Oncol Biol Phys. 2000;46:995–8.CrossRefPubMedGoogle Scholar
  2. 2.
    WK MN. New insights into the pathogenesis of radiation-induced intestinal dysfunction. Aliment Pharmacol Ther. 2000;14:523–8.CrossRefGoogle Scholar
  3. 3.
    Beck PL, Wong JF, Li Y, et al. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology. 2004;126:796–808.CrossRefPubMedGoogle Scholar
  4. 4.
    Duncan M, Grant G. Oral and intestinal mucositis – causes and possible treatments. Aliment Pharmacol Ther. 2003;18:853–74.CrossRefPubMedGoogle Scholar
  5. 5.
    Leupin N, Curschmann J, Kranzbühler H, et al. Acute radiation colitis in patients treated with short-term preoperative radiotherapy for rectal cancer. Am J Surg Pathol. 2002;26:498–504.CrossRefPubMedGoogle Scholar
  6. 6.
    Fajardo LF. The pathology of ionizing radiation as defined by morphologic patterns. Acta Oncol. 2005;44:13–22.CrossRefPubMedGoogle Scholar
  7. 7.
    Suzuki T, Sadahiro S, Tanaka A, et al. Biopsy specimens obtained 7 days after starting chemoradiotherapy provide reliable predictors of response to CRT for rectal cancer. Int J Radiat Oncol Biol Phys. 2013;85:1232–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Tang JH, An X, Lin X, et al. The value of forceps biopsy and core needle biopsy in prediction of pathological complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Oncotarget. 2015;32:33919–25.Google Scholar
  9. 9.
    Glotzer DJ, Glick ME, Goldman H. Proctitis and colitis following diversion of the fecal stream. Gastroenterology. 1981;80:438–41.PubMedGoogle Scholar
  10. 10.
    Komorowski RA. Histologic spectrum of diversion colitis. Am J Surg Pathol. 1990;14:548–54.CrossRefPubMedGoogle Scholar
  11. 11.
    Whitehead R. Colitis: problems in definition and diagnosis. Virch Arch Pathol Anat. 1990;47:187–90.CrossRefGoogle Scholar
  12. 12.
    Toolenaar TA, Freundt I, Huikeshoven FJ, et al. The occurrence of diversion colitis in patients with a sigmoid neovagina. Hum Pathol. 1993;24:846–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Geraghty JM, Talbot IC. Diversion colitis: histological features in the colon and rectum after defunctioning colostomy. Gut. 1991;32:1020–3.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Villanacci V, Talbot IC, Rossi E, et al. Ischaemia: a pathogenetic clue in diversion colitis? Color Dis. 2007;9:601–5.CrossRefGoogle Scholar
  15. 15.
    Roe AM, Warren BF, Brodribb AJM, et al. Diversion colitis and involution of the defunctioned anorectum. Gut. 1993;34:382–5.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Antonioli DA. Pediatric inflammatory bowel disease. Pediatr Dev Pathol. 2005;8:2–19.CrossRefPubMedGoogle Scholar
  17. 17.
    Yantiss RK, Odze RD. Diagnostic difficulties in inflammatory bowel disease pathology. Histopathology. 2006;48:116–32.CrossRefPubMedGoogle Scholar
  18. 18.
    Epstein RJ, McDonald GB, Sale GE, et al. The diagnostic accuracy of the rectal biopsy in acute graft-versus-host-disease: a prospective study of thirteen patients. Gastroenterology. 1980;78:764–71.PubMedGoogle Scholar
  19. 19.
    Snover DC, Weisdorf SA, Vercellotti GM, et al. A histopathologic study of gastric and small intestinal graft-versus-host disease following allogeneic bone marrow transplantation. Hum Pathol. 1985;16:387–92.CrossRefPubMedGoogle Scholar
  20. 20.
    Shulman HM, Kleiner D, Lee SJ, et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: II. Pathology Working Group report. Biol Blood Marrow Transplant. 2006;12:31–47.CrossRefPubMedGoogle Scholar
  21. 21.
    Lin J, Fan R, Zhao Z, et al. Is the presence of 6 or fewer crypt apoptotic bodies sufficient for the diagnosis of graft versus host disease? A decade of experience at a single institution. Am J Surg Pathol. 2013;37:539–47.CrossRefPubMedGoogle Scholar
  22. 22.
    Star KV, Ho VT, Wang HH, et al. Histologic features in colon biopsies can discriminate mycophenolate from GVHD-induced colitis. Am J Surg Pathol. 2013;37:1319–28.CrossRefPubMedGoogle Scholar
  23. 23.
    Snover DC. Mucosal damage simulating acute graft-versus-host reaction in cytomegalovirus colitis. Transplantation. 1985;39:670–1.CrossRefGoogle Scholar
  24. 24.
    Umetsu S, Brown I, Langner C, et al. Autoimmune enteropathies. Virchows Arch. Virchows Arch. 2018;472:55–66.CrossRefPubMedGoogle Scholar
  25. 25.
    Shimoni A, Rimon U, Hertz M, et al. CT in the clinical and prognostic evaluation of acute graft versus host disease of the gastrointestinal tract. Br J Radiol. 2012;85:e416–23.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Sung D, Iuga AC, Kato T, et al. Crypt apoptotic body counts in normal ileal biopsies overlap with graft-versus-host disease and acute cellular rejection of small bowel allografts. Hum Pathol. 2016;56:89–92.CrossRefPubMedGoogle Scholar
  27. 27.
    Bhatt AS, Freeman SS, Herrera AF, et al. Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome. N Engl J Med. 2013;369:517–28.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Herrera AF, Soriano G, Bellizzi AM, et al. Cord colitis syndrome in cord-blood stem-cell transplantation. N Engl J Med. 2011;365:815–24.CrossRefPubMedGoogle Scholar
  29. 29.
    Gupta NK, Masia R. Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract. Am J Surg Pathol. 2013;37:1109–13.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Shimoji S, Kato K, Eriguchi Y, et al. Evaluating the association between histological manifestations of cord colitis syndrome with GVHD. Bone Marrow Transplant. 2013;48:1249–52.CrossRefPubMedGoogle Scholar
  31. 31.
    Milano F, Shulman HM, Guthrie KA, et al. Late-onset colitis after cord blood transplantation is consistent with graft-versus-host-disease: result of a blinded histopathological review. Biol Blood Marrow Transplant. 2014;20:1008–13.CrossRefPubMedGoogle Scholar
  32. 32.
    Warren M, Jodele S, Dandoy C, et al. A complete histopathological approach to gastrointestinal biopsy from hematopoietic stem cell transplant patients with evidence of transplant-associated gastrointestinal thrombotic micro-angiopathy. Arch Pathol Lab Med. 2017;141:1558–66.CrossRefPubMedGoogle Scholar
  33. 33.
    Wong NACS. Gastrointestinal pathology in transplant patients. Histopathology. 2015;66:467–79.CrossRefPubMedGoogle Scholar
  34. 34.
    Mills AM, Guo FP, Copland AP, et al. A comparison of CMV detection in gastrointestinal mucosal biopsies using immunohistochemistry and PCR performed on formalin-fixed, paraffin-embedded tissue. Am J Surg Pathol. 2013;37:995–1000.CrossRefPubMedGoogle Scholar
  35. 35.
    Selbst MK, Ahrens WA, Robert ME, et al. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Mod Pathol. 2009;22:737–43.CrossRefPubMedGoogle Scholar
  36. 36.
    Wörns MA, Lohse AW, Neurath MF, et al. Five cases of de novo inflammatory bowel disease after orthotopic liver transplantation. Am J Gastroenterol. 2006;101:1931–7.CrossRefPubMedGoogle Scholar
  37. 37.
    Vu F, Maillard M, Pascual M, et al. De novo inflammatory bowel disease after liver transplantation: description of four new cases and a review of the literature. Gastroenterol Clin Biol. 2006;30:1096–101.CrossRefPubMedGoogle Scholar
  38. 38.
    Geboes K. Crohn’s disease and solid organ transplantation. Gastroenterol Hepatol. 2008;4:879–80.Google Scholar
  39. 39.
    Fattahi MR, Malek-Hosseini SA, Sivandzadeh GR, et al. Clinical course of ulcerative colitis after liver transplantation in patients with concomitant primary sclerosing cholangitis and ulcerative colitis. Inflamm Bowel Dis. 2017;23:1160–7.CrossRefPubMedGoogle Scholar
  40. 40.
    Daniels JA, Gibson MK, Xu L, et al. Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect. Am J Surg Pathol. 2008;32:473–7.CrossRefPubMedGoogle Scholar
  41. 41.
    Sachak T, Arnold MA, Naina BV, et al. Neutropenic enterocolitis: new insights into a deadly entity. Am J Surg Pathol. 2015;39:1635–42.CrossRefPubMedGoogle Scholar
  42. 42.
    Ahishali E, Uygur-Bayramicli O, Dolapcioglu C, et al. Chemical colitis due to glutaraldehyde: case series and review of the literature. Dig Dis Sci. 2009;54:2541–5.CrossRefPubMedGoogle Scholar
  43. 43.
    Nakasono M, Hirokawa M, Muguruma N, et al. Colonic pseudolipomatosis, microscopically classified into two groups. J Gastroenterol Hepatol. 2006;21:65–70.CrossRefPubMedGoogle Scholar
  44. 44.
    Koreishi A, Lauwers GY, Misdraji L. Pneumatosis intestinalis: a challenging biopsy diagnosis. Am J Surg Pathol. 2007;31:1469–75.CrossRefPubMedGoogle Scholar
  45. 45.
    Kara M, Turan I, Polat Z, et al. Chemical colitis caused by peracetic acid or hydrogen peroxide: a challenging dilemma. Endoscopy. 2010;42:E3–4.CrossRefPubMedGoogle Scholar
  46. 46.
    Chavez JA, Chen W, Frankel WL, et al. Hydrophilic polymer-associated ischemic enterocolitis. Am J Surg Pathol. 2017;41:271–6.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyCliniques Universitaires St Luc, UCLBrusselsBelgium
  2. 2.Department of Pathology, University Hospital San Giovanni di DioUniversity of CagliariCagliariItaly
  3. 3.Department of Surgical Sciences, University Hospital San Giovanni di DioUniversity of CagliariCagliariItaly
  4. 4.Department of PathologyGhent University HospitalGhentBelgium
  5. 5.Department of PathologyKU LeuvenLeuvenBelgium

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