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Inflammasome in the Pathogenesis of Pulmonary Diseases

  • Fengying Xu
  • Zongmei Wen
  • Xueying Shi
  • Jie Fan
Chapter
Part of the Experientia Supplementum book series (EXS, volume 108)

Abstract

Lung diseases are common and significant causes of illness and death around the world. Inflammasomes have emerged as an important regulator of lung diseases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. The cleavage to turn IL-1 beta and IL-18 from their precursors into the active forms is tightly regulated by inflammasomes. In this chapter, we structurally review current evidence of inflammasome-related components in the pathogenesis of acute and chronic lung diseases, focusing on the “inflammasome-caspase-1-IL-1 beta/IL-18” axis.

Keywords

Inflammasomes Infectious pulmonary diseases Lung injury Smoking Chronic obstructive pulmonary disease 

References

  1. Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, Ting JP (2009) The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30(4):556–565.  https://doi.org/10.1016/j.immuni.2009.02.005CrossRefPubMedPubMedCentralGoogle Scholar
  2. Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP (2012) Analysis of NLRP3 in the development of allergic airway disease in mice. J Immunol (Baltimore, MD: 1950) 188(6):2884–2893.  https://doi.org/10.4049/jimmunol.1102488CrossRefGoogle Scholar
  3. Amer A, Franchi L, Kanneganti TD, Body-Malapel M, Ozoren N, Brady G, Meshinchi S, Jagirdar R, Gewirtz A, Akira S, Nunez G (2006) Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 281(46):35217–35223.  https://doi.org/10.1074/jbc.M604933200CrossRefPubMedGoogle Scholar
  4. Arlehamn CS, Evans TJ (2011) Pseudomonas aeruginosa pilin activates the inflammasome. Cell Microbiol 13(3):388–401.  https://doi.org/10.1111/j.1462-5822.2010.01541.xCrossRefPubMedGoogle Scholar
  5. Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME (2011) Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J Immunol (Baltimore, MD: 1950) 187(1):64–73.  https://doi.org/10.4049/jimmunol.1100500CrossRefGoogle Scholar
  6. Bartziokas K, Papaioannou AI, Loukides S, Papadopoulos A, Haniotou A, Papiris S, Kostikas K (2014) Serum uric acid as a predictor of mortality and future exacerbations of COPD. Eur Respir J 43(1):43–53.  https://doi.org/10.1183/09031936.00209212CrossRefPubMedGoogle Scholar
  7. Bellamy R, Ruwende C, Corrah T, McAdam KP, Whittle HC, Hill AV (1998) Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis. Tuber Lung Dis 79(2):83–89.  https://doi.org/10.1054/tuld.1998.0009CrossRefPubMedGoogle Scholar
  8. Besnard AG, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y, Quesniaux V, Ryffel B, Togbe D (2011) NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant. Allergy 66(8):1047–1057.  https://doi.org/10.1111/j.1398-9995.2011.02586.xCrossRefPubMedGoogle Scholar
  9. Bhakdi S, Muhly M, Korom S, Hugo F (1989) Release of interleukin-1 beta associated with potent cytocidal action of staphylococcal alpha-toxin on human monocytes. Infect Immun 57(11):3512–3519PubMedPubMedCentralGoogle Scholar
  10. Boland S, Baeza-Squiban A, Fournier T, Houcine O, Gendron MC, Chevrier M, Jouvenot G, Coste A, Aubier M, Marano F (1999) Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production. Am J Phys 276(4 Pt 1):L604–L613Google Scholar
  11. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI (1992) Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 89(5):958–967CrossRefPubMedGoogle Scholar
  12. Brown GP, Iwamoto GK, Monick MM, Hunninghake GW (1989) Cigarette smoking decreases interleukin 1 release by human alveolar macrophages. Am J Phys 256(2 Pt 1):C260–C264CrossRefGoogle Scholar
  13. Cai S, Batra S, Wakamatsu N, Pacher P, Jeyaseelan S (2012) NLRC4 inflammasome-mediated production of IL-1beta modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol 188(11):5623–5635.  https://doi.org/10.4049/jimmunol.1200195CrossRefPubMedPubMedCentralGoogle Scholar
  14. Carlsson F, Kim J, Dumitru C, Barck KH, Carano RA, Sun M, Diehl L, Brown EJ (2010) Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection. PLoS Pathog 6(5):e1000895.  https://doi.org/10.1371/journal.ppat.1000895CrossRefPubMedPubMedCentralGoogle Scholar
  15. Case CL, Shin S, Roy CR (2009) Asc and Ipaf inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Infect Immun 77(5):1981–1991.  https://doi.org/10.1128/iai.01382-08CrossRefPubMedPubMedCentralGoogle Scholar
  16. Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS (2008) The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A 105(26):9035–9040.  https://doi.org/10.1073/pnas.0803933105CrossRefPubMedPubMedCentralGoogle Scholar
  17. Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Loberg EM, Christensen G, Larsen KO, Skjonsberg OH (2015) Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol 309(4):L378–L387.  https://doi.org/10.1152/ajplung.00342.2014CrossRefPubMedGoogle Scholar
  18. Chen CC, Tsai SH, Lu CC, Hu ST, Wu TS, Huang TT, Said-Sadier N, Ojcius DM, Lai HC (2012) Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection. PLoS One 7(4):e36292.  https://doi.org/10.1371/journal.pone.0036292CrossRefPubMedPubMedCentralGoogle Scholar
  19. Chensue SW, Warmington KS, Berger AE, Tracey DE (1992) Immunohistochemical demonstration of interleukin-1 receptor antagonist protein and interleukin-1 in human lymphoid tissue and granulomas. Am J Pathol 140(2):269–275PubMedPubMedCentralGoogle Scholar
  20. Chow MT, Tschopp J, Moller A, Smyth MJ (2012) NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma. Immunol Cell Biol 90(10):983–986.  https://doi.org/10.1038/icb.2012.46CrossRefPubMedGoogle Scholar
  21. Churg A, Zhou S, Wang X, Wang R, Wright JL (2009) The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling. Am J Respir Cell Mol Biol 40(4):482–490.  https://doi.org/10.1165/rcmb.2008-0038OCCrossRefPubMedGoogle Scholar
  22. Cicko S, Lucattelli M, Muller T, Lommatzsch M, De Cunto G, Cardini S, Sundas W, Grimm M, Zeiser R, Durk T, Zissel G, Boeynaems JM, Sorichter S, Ferrari D, Di Virgilio F, Virchow JC, Lungarella G, Idzko M (2010) Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema. J Immunol 185(1):688–697.  https://doi.org/10.4049/jimmunol.0904042CrossRefPubMedGoogle Scholar
  23. Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA (2009) Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One 4(10):e7446.  https://doi.org/10.1371/journal.pone.0007446CrossRefPubMedPubMedCentralGoogle Scholar
  24. Davis GS, Pfeiffer LM, Hemenway DR (1998) Persistent overexpression of interleukin-1beta and tumor necrosis factor-alpha in murine silicosis. J Environ Pathol Toxicol Oncol 17(2):99–114PubMedGoogle Scholar
  25. Denton AE, Doherty PC, Turner SJ, La Gruta NL (2007) IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells. Eur J Immunol 37(2):368–375.  https://doi.org/10.1002/eji.200636766CrossRefPubMedGoogle Scholar
  26. Di Stefano A, Caramori G, Barczyk A, Vicari C, Brun P, Zanini A, Cappello F, Garofano E, Padovani A, Contoli M, Casolari P, Durham AL, Chung KF, Barnes PJ, Papi A, Adcock I, Balbi B (2014) Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD. Thorax 69(6):516–524.  https://doi.org/10.1136/thoraxjnl-2012-203062CrossRefPubMedPubMedCentralGoogle Scholar
  27. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM (2012) Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med 185(11):1225–1234.  https://doi.org/10.1164/rccm.201201-0003OCCrossRefPubMedPubMedCentralGoogle Scholar
  28. Dorhoi A, Nouailles G, Jorg S, Hagens K, Heinemann E, Pradl L, Oberbeck-Muller D, Duque-Correa MA, Reece ST, Ruland J, Brosch R, Tschopp J, Gross O, Kaufmann SH (2012) Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol 42(2):374–384.  https://doi.org/10.1002/eji.201141548CrossRefPubMedGoogle Scholar
  29. Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (New York, NY) 320(5876):674–677.  https://doi.org/10.1126/science.1156995CrossRefGoogle Scholar
  30. Doz E, Noulin N, Boichot E, Guénon I, Fick L, Le BM, Lagente V, Ryffel B, Schnyder B, Quesniaux VF (2008) Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol 180(9):1169–1178CrossRefPubMedGoogle Scholar
  31. Eltom S, Stevenson CS, Rastrick J, Dale N, Raemdonck K, Wong S, Catley MC, Belvisi MG, Birrell MA (2011) P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke. PLoS One 6(9):e24097CrossRefPubMedPubMedCentralGoogle Scholar
  32. Eltom S, Belvisi MG, Stevenson CS, Maher SA, Dubuis E, Fitzgerald KA, Birrell MA (2014) Role of the inflammasome-caspase1/11-IL-1/18 axis in cigarette smoke driven airway inflammation: an insight into the pathogenesis of COPD. PLoS One 9(11):e112829CrossRefPubMedPubMedCentralGoogle Scholar
  33. Franchi L, Stoolman J, Kanneganti TD, Verma A, Ramphal R, Nunez G (2007) Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol 37(11):3030–3039.  https://doi.org/10.1002/eji.200737532CrossRefPubMedGoogle Scholar
  34. Frank JA, Pittet JF, Wray C, Matthay MA (2008) Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax 63(2):147–153.  https://doi.org/10.1136/thx.2007.079608CrossRefPubMedGoogle Scholar
  35. Fremond CM, Togbe D, Doz E, Rose S, Vasseur V, Maillet I, Jacobs M, Ryffel B, Quesniaux VF (2007) IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection. J Immunol 179(2):1178–1189CrossRefPubMedGoogle Scholar
  36. Fujii T, Hayashi S, Hogg JC, Vincent R, Van Eeden SF (2001) Particulate matter induces cytokine expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol 25(3):265–271CrossRefPubMedGoogle Scholar
  37. Fukumoto J, Fukumoto I, Parthasarathy PT, Cox R, Huynh B, Ramanathan GK, Venugopal RB, Allen-Gipson DS, Lockey RF, Kolliputi N (2013) NLRP3 deletion protects from hyperoxia-induced acute lung injury. Am J Physiol Cell Physiol 305(2):C182–C189.  https://doi.org/10.1152/ajpcell.00086.2013CrossRefPubMedPubMedCentralGoogle Scholar
  38. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF (2008) Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res 102(7):804–812.  https://doi.org/10.1161/circresaha.107.161067CrossRefPubMedPubMedCentralGoogle Scholar
  39. Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I (2007) IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117(12):3786–3799.  https://doi.org/10.1172/jci32285CrossRefPubMedPubMedCentralGoogle Scholar
  40. Gasse P, Riteau N, Charron S, Girre S, Fick L, Petrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I (2009) Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 179(10):903–913.  https://doi.org/10.1164/rccm.200808-1274OCCrossRefPubMedGoogle Scholar
  41. Gasse P, Riteau N, Vacher R, Michel ML, Fautrel A, di Padova F, Fick L, Charron S, Lagente V, Eberl G, Le Bert M, Quesniaux VF, Huaux F, Leite-de-Moraes M, Ryffel B, Couillin I (2011) IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. PLoS One 6(8):e23185.  https://doi.org/10.1371/journal.pone.0023185CrossRefPubMedPubMedCentralGoogle Scholar
  42. Giacomini E, Iona E, Ferroni L, Miettinen M, Fattorini L, Orefici G, Julkunen I, Coccia EM (2001) Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response. J Immunol 166(12):7033–7041CrossRefPubMedGoogle Scholar
  43. Girardelli M, Maestri I, Rinaldi RR, Tognon M, Boldorini R, Bovenzi M, Crovella S, Comar M (2012) NLRP1 polymorphisms in patients with asbestos-associated mesothelioma. Infect Agent Cancer 7(1):25.  https://doi.org/10.1186/1750-9378-7-25CrossRefPubMedPubMedCentralGoogle Scholar
  44. Grassme H, Carpinteiro A, Edwards MJ, Gulbins E, Becker KA (2014) Regulation of the inflammasome by ceramide in cystic fibrosis lungs. Cell Physiol Biochem 34(1):45–55.  https://doi.org/10.1159/000362983CrossRefPubMedGoogle Scholar
  45. Guo J, Gu N, Chen J, Shi T, Zhou Y, Rong Y, Zhou T, Yang W, Cui X, Chen W (2013) Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. Arch Toxicol 87(11):1963–1973.  https://doi.org/10.1007/s00204-013-1063-zCrossRefPubMedGoogle Scholar
  46. Haegens A, Barrett TF, Gell J, Shukla A, Macpherson M, Vacek P, Poynter ME, Butnor KJ, Janssen-Heininger YM, Steele C, Mossman BT (2007) Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo. J Immunol 178(3):1800–1808CrossRefPubMedGoogle Scholar
  47. Hamilton RF Jr, Buford M, Xiang C, Wu N, Holian A (2012) NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination. Inhal Toxicol 24(14):995–1008.  https://doi.org/10.3109/08958378.2012.745633CrossRefPubMedPubMedCentralGoogle Scholar
  48. Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Nunez G (2009) Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol 183(9):5823–5829.  https://doi.org/10.4049/jimmunol.0900444CrossRefPubMedPubMedCentralGoogle Scholar
  49. Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER (2010) Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 125(5):1028–1036.e1013.  https://doi.org/10.1016/j.jaci.2010.02.008CrossRefPubMedPubMedCentralGoogle Scholar
  50. He X, Qian Y, Li Z, Fan EK, Li Y, Wu L, Billiar TR, Wilson MA, Shi X, Fan J (2016) TLR4-upregulated IL-1beta and IL-1RI promote alveolar macrophage pyroptosis and lung inflammation through an autocrine mechanism. Sci Rep 6:31663.  https://doi.org/10.1038/srep31663CrossRefPubMedPubMedCentralGoogle Scholar
  51. Hennet T, Ziltener HJ, Frei K, Peterhans E (1992) A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. J Immunol 149(3):932–939PubMedGoogle Scholar
  52. Hillegass JM, Miller JM, MacPherson MB, Westbom CM, Sayan M, Thompson JK, Macura SL, Perkins TN, Beuschel SL, Alexeeva V, Pass HI, Steele C, Mossman BT, Shukla A (2013) Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells. Part Fibre Toxicol 10:39.  https://doi.org/10.1186/1743-8977-10-39CrossRefPubMedPubMedCentralGoogle Scholar
  53. Hirota JA, Hirota SA, Warner SM, Stefanowicz D, Shaheen F, Beck PL, Macdonald JA, Hackett TL, Sin DD, Van Eeden S, Knight DA (2012) The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter. J Allergy Clin Immunol 129(4):1116–1125.e1116.  https://doi.org/10.1016/j.jaci.2011.11.033CrossRefPubMedGoogle Scholar
  54. Hitomi Y, Ebisawa M, Tomikawa M, Imai T, Komata T, Hirota T, Harada M, Sakashita M, Suzuki Y, Shimojo N, Kohno Y, Fujita K, Miyatake A, Doi S, Enomoto T, Taniguchi M, Higashi N, Nakamura Y, Tamari M (2009) Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol 124(4):779–785.e776.  https://doi.org/10.1016/j.jaci.2009.07.044CrossRefPubMedGoogle Scholar
  55. Horiba M, Qutna N, Gendapodi P, Agrawal S, Sapkota K, Abel P, Townley RG (2011) Effect of IL-1beta and TNF-alpha vs IL-13 on bronchial hyperresponsiveness, beta2-adrenergic responses and cellularity of bronchial alveolar lavage fluid. Auton Autacoid Pharmacol 31(3–4):37–49.  https://doi.org/10.1111/j.1474-8673.2011.00465.xCrossRefPubMedGoogle Scholar
  56. Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL, Fitzgerald KA, Latz E (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9(8):847–856.  https://doi.org/10.1038/ni.1631CrossRefPubMedPubMedCentralGoogle Scholar
  57. Hoshino T, Okamoto M, Sakazaki Y, Kato S, Young HA, Aizawa H (2009) Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Am J Respir Cell Mol Biol 41(6):661–670.  https://doi.org/10.1165/rcmb.2008-0182OCCrossRefPubMedGoogle Scholar
  58. Hutyrova B, Pantelidis P, Drabek J, Zurkova M, Kolek V, Lenhart K, Welsh KI, Du Bois RM, Petrek M (2002) Interleukin-1 gene cluster polymorphisms in sarcoidosis and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 165(2):148–151.  https://doi.org/10.1164/ajrccm.165.2.2106004CrossRefPubMedGoogle Scholar
  59. Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A (2009) Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 206(1):79–87.  https://doi.org/10.1084/jem.20081667CrossRefPubMedPubMedCentralGoogle Scholar
  60. Ichinohe T, Pang IK, Iwasaki A (2010) Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat Immunol 11(5):404–410.  https://doi.org/10.1038/ni.1861CrossRefPubMedPubMedCentralGoogle Scholar
  61. Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, Muskens F, Hoogsteden HC, Luttmann W, Ferrari D, Di Virgilio F, Virchow JC Jr, Lambrecht BN (2007) Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med 13(8):913–919.  https://doi.org/10.1038/nm1617CrossRefPubMedGoogle Scholar
  62. Iyer R, Hamilton RF, Li L, Holian A (1996) Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol 141(1):84–92.  https://doi.org/10.1006/taap.1996.0263CrossRefPubMedGoogle Scholar
  63. Ji X, Hou Z, Wang T, Jin K, Fan J, Luo C, Chen M, Han R, Ni C (2012) Polymorphisms in inflammasome genes and risk of coal workers’ pneumoconiosis in a Chinese population. PLoS One 7(10):e47949.  https://doi.org/10.1371/journal.pone.0047949CrossRefPubMedPubMedCentralGoogle Scholar
  64. Jonas D, Walev I, Berger T, Liebetrau M, Palmer M, Bhakdi S (1994) Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation. Infect Immun 62(4):1304–1312PubMedPubMedCentralGoogle Scholar
  65. Juffermans NP, Florquin S, Camoglio L, Verbon A, Kolk AH, Speelman P, van Deventer SJ, van Der Poll T (2000) Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis. J Infect Dis 182(3):902–908.  https://doi.org/10.1086/315771CrossRefPubMedGoogle Scholar
  66. Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA (2007) IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol 178(3):1948–1959CrossRefPubMedGoogle Scholar
  67. Kang MJ, Choi JM, Kim BH, Lee CM, Cho WK, Choe G, Kim DH, Lee CG, Elias JA (2012) IL-18 induces emphysema and airway and vascular remodeling via IFN-gamma, IL-17A, and IL-13. Am J Respir Crit Care Med 185(11):1205–1217.  https://doi.org/10.1164/rccm.201108-1545OCCrossRefPubMedPubMedCentralGoogle Scholar
  68. Kaukoranta-Tolvanen SS, Teppo AM, Laitinen K, Saikku P, Linnavuori K, Leinonen M (1996) Growth of Chlamydia pneumoniae in cultured human peripheral blood mononuclear cells and induction of a cytokine response. Microb Pathog 21(3):215–221.  https://doi.org/10.1006/mpat.1996.0056CrossRefPubMedGoogle Scholar
  69. Kawakami K, Qureshi MH, Zhang T, Okamura H, Kurimoto M, Saito A (1997) IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production. J Immunol 159(11):5528–5534PubMedGoogle Scholar
  70. Kawakami K, Koguchi Y, Qureshi MH, Kinjo Y, Yara S, Miyazato A, Kurimoto M, Takeda K, Akira S, Saito A (2000a) Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice. FEMS Microbiol Lett 186(1):121–126CrossRefPubMedGoogle Scholar
  71. Kawakami K, Koguchi Y, Qureshi MH, Miyazato A, Yara S, Kinjo Y, Iwakura Y, Takeda K, Akira S, Kurimoto M, Saito A (2000b) IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J Immunol 165(2):941–947CrossRefPubMedGoogle Scholar
  72. Kim SR, Kim DI, Kim SH, Lee H, Lee KS, Cho SH, Lee YC (2014) NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation. Cell Death Dis 5:e1498.  https://doi.org/10.1038/cddis.2014.460CrossRefPubMedPubMedCentralGoogle Scholar
  73. King HC, Khera-Butler T, James P, Oakley BB, Erenso G, Aseffa A, Knight R, Wellington EM, Courtenay O (2017) Environmental reservoirs of pathogenic mycobacteria across the Ethiopian biogeographical landscape. PLoS One 12(3):e0173811CrossRefPubMedPubMedCentralGoogle Scholar
  74. Kinjo Y, Kawakami K, Uezu K, Yara S, Miyagi K, Koguchi Y, Hoshino T, Okamoto M, Kawase Y, Yokota K, Yoshino K, Takeda K, Akira S, Saito A (2002) Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40. J Immunol 169(1):323–329CrossRefPubMedGoogle Scholar
  75. Kitasato Y, Hoshino T, Okamoto M, Kato S, Koda Y, Nagata N, Kinoshita M, Koga H, Yoon DY, Asao H, Ohmoto H, Koga T, Rikimaru T, Aizawa H (2004) Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 31(6):619–625.  https://doi.org/10.1165/rcmb.2003-0306OCCrossRefPubMedGoogle Scholar
  76. Kleinnijenhuis J, Joosten LA, van de Veerdonk FL, Savage N, van Crevel R, Kullberg BJ, van der Ven A, Ottenhoff TH, Dinarello CA, van der Meer JW, Netea MG (2009) Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis. Eur J Immunol 39(7):1914–1922.  https://doi.org/10.1002/eji.200839115CrossRefPubMedGoogle Scholar
  77. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J (2001) Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 107(12):1529–1536.  https://doi.org/10.1172/jci12568CrossRefPubMedPubMedCentralGoogle Scholar
  78. Kolliputi N, Shaik RS, Waxman AB (2010) The inflammasome mediates hyperoxia-induced alveolar cell permeability. J Immunol 184(10):5819–5826.  https://doi.org/10.4049/jimmunol.0902766CrossRefPubMedPubMedCentralGoogle Scholar
  79. Konno S, Gonokami Y, Kurokawa M, Kawazu K, Asano K, Okamoto K, Adachi M (1996) Cytokine concentrations in sputum of asthmatic patients. Int Arch Allergy Immunol 109(1):73–78CrossRefPubMedGoogle Scholar
  80. Koo IC, Wang C, Raghavan S, Morisaki JH, Cox JS, Brown EJ (2008) ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection. Cell Microbiol 10(9):1866–1878.  https://doi.org/10.1111/j.1462-5822.2008.01177.xCrossRefPubMedPubMedCentralGoogle Scholar
  81. Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis e Sousa C, Hammad H, Lambrecht BN (2011) An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 34(4):527–540.  https://doi.org/10.1016/j.immuni.2011.03.015CrossRefPubMedGoogle Scholar
  82. Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar AP, Wolthuis EK, Choi G, Roelofs JJ, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW (2012) Ventilator-induced lung injury is mediated by the NLRP3 inflammasome. Anesthesiology 116(5):1104–1115.  https://doi.org/10.1097/ALN.0b013e3182518bc0CrossRefPubMedGoogle Scholar
  83. Kurenuma T, Kawamura I, Hara H, Uchiyama R, Daim S, Dewamitta SR, Sakai S, Tsuchiya K, Nomura T, Mitsuyama M (2009) The RD1 locus in the Mycobacterium tuberculosis genome contributes to activation of caspase-1 via induction of potassium ion efflux in infected macrophages. Infect Immun 77(9):3992–4001.  https://doi.org/10.1128/iai.00015-09CrossRefPubMedPubMedCentralGoogle Scholar
  84. Kuschner WG, D’Alessandro A, Wong H, Blanc PD (1996) Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J 9(10):1989–1994CrossRefPubMedGoogle Scholar
  85. Kuwano K, Kunitake R, Maeyama T, Hagimoto N, Kawasaki M, Matsuba T, Yoshimi M, Inoshima I, Yoshida K, Hara N (2001) Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 280(2):L316–L325CrossRefPubMedGoogle Scholar
  86. Law K, Weiden M, Harkin T, Tchou-Wong K, Chi C, Rom WN (1996) Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis. Am J Respir Crit Care Med 153(2):799–804.  https://doi.org/10.1164/ajrccm.153.2.8564135CrossRefPubMedGoogle Scholar
  87. Lee HM, Yuk JM, Kim KH, Jang J, Kang G, Park JB, Son JW, Jo EK (2012) Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1. Immunol Cell Biol 90(6):601–610.  https://doi.org/10.1038/icb.2011.72CrossRefPubMedGoogle Scholar
  88. Lee S, Suh GY, Ryter SW, Choi AM (2016) Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease. Am J Respir Cell Mol Biol 54(2):151–160.  https://doi.org/10.1165/rcmb.2015-0231TRCrossRefPubMedPubMedCentralGoogle Scholar
  89. Leff JA, Baer JW, Bodman ME, Kirkman JM, Shanley PF, Patton LM, Beehler CJ, McCord JM, Repine JE (1994) Interleukin-1-induced lung neutrophil accumulation and oxygen metabolite-mediated lung leak in rats. Am J Phys 266(1 Pt 1):L2–L8Google Scholar
  90. Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S (2014) Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection. Am J Respir Crit Care Med 189(12):1461–1468.  https://doi.org/10.1164/rccm.201311-2103PPCrossRefPubMedPubMedCentralGoogle Scholar
  91. Lin SM, Lin HC, Lee KY, Huang CD, Liu CY, Wang CH, Kuo HP (2007) Ventilator-induced injury augments interleukin-1beta production and neutrophil sequestration in lipopolysaccharide-treated lungs. Shock (Augusta, Ga) 28(4):453–460.  https://doi.org/10.1097/shk.0b013e3180487fb5CrossRefGoogle Scholar
  92. Liu B, Mori I, Hossain MJ, Dong L, Takeda K, Kimura Y (2004) Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity. J Gen Virol 85(Pt 2):423–428.  https://doi.org/10.1099/vir.0.19596-0CrossRefPubMedGoogle Scholar
  93. Liu DH, Cui W, Chen Q, Huang CM (2011) Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scand J Clin Lab Invest 71(7):593–597.  https://doi.org/10.3109/00365513.2011.597871CrossRefPubMedGoogle Scholar
  94. Luzar MA, Thomassen MJ, Montie TC (1985) Flagella and motility alterations in Pseudomonas aeruginosa strains from patients with cystic fibrosis: relationship to patient clinical condition. Infect Immun 50(2):577–582PubMedPubMedCentralGoogle Scholar
  95. Ma SF, Grigoryev DN, Taylor AD, Nonas S, Sammani S, Ye SQ, Garcia JG (2005) Bioinformatic identification of novel early stress response genes in rodent models of lung injury. Am J Physiol Lung Cell Mol Physiol 289(3):L468–L477.  https://doi.org/10.1152/ajplung.00109.2005CrossRefPubMedGoogle Scholar
  96. Mahenthiralingam E, Campbell ME, Speert DP (1994) Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect Immun 62(2):596–605PubMedPubMedCentralGoogle Scholar
  97. Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME (2013) Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. Am J Respir Cell Mol Biol 48(5):655–664.  https://doi.org/10.1165/rcmb.2012-0423OCCrossRefPubMedPubMedCentralGoogle Scholar
  98. Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V (2008) Mycobacterium tuberculosis prevents inflammasome activation. Cell Host Microbe 3(4):224–232.  https://doi.org/10.1016/j.chom.2008.03.003CrossRefPubMedPubMedCentralGoogle Scholar
  99. Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Nunez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A (2010) Caspase-1 independent IL-1beta production is critical for host resistance to Mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 184(7):3326–3330.  https://doi.org/10.4049/jimmunol.0904189CrossRefPubMedPubMedCentralGoogle Scholar
  100. McElvania Tekippe E, Allen IC, Hulseberg PD, Sullivan JT, McCann JR, Sandor M, Braunstein M, Ting JP (2010) Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PLoS One 5(8):e12320.  https://doi.org/10.1371/journal.pone.0012320CrossRefPubMedPubMedCentralGoogle Scholar
  101. McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Petrilli V, Andrew PW, Kadioglu A, Lavelle EC (2010) Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog 6(11):e1001191.  https://doi.org/10.1371/journal.ppat.1001191CrossRefPubMedPubMedCentralGoogle Scholar
  102. Miao EA, Ernst RK, Dors M, Mao DP, Aderem A (2008) Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A 105(7):2562–2567.  https://doi.org/10.1073/pnas.0712183105CrossRefPubMedPubMedCentralGoogle Scholar
  103. Mishra BB, Moura-Alves P, Sonawane A, Hacohen N, Griffiths G, Moita LF, Anes E (2010) Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome. Cell Microbiol 12(8):1046–1063.  https://doi.org/10.1111/j.1462-5822.2010.01450.xCrossRefPubMedGoogle Scholar
  104. Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M, Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M, Sugiyama Y, Takahashi M (2015) NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1beta. J Biol Chem 290(8):5065–5077.  https://doi.org/10.1074/jbc.M114.603217CrossRefPubMedGoogle Scholar
  105. Moncao-Ribeiro LC, Faffe DS, Santana PT, Vieira FS, da Graca CL, Marques-da-Silva C, Machado MN, Caruso-Neves C, Zin WA, Borojevic R, Takiya CM, Coutinho-Silva R (2014) P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica. PLoS One 9(10):e110185.  https://doi.org/10.1371/journal.pone.0110185CrossRefPubMedPubMedCentralGoogle Scholar
  106. Morimoto Y, Ogami A, Todoroki M, Yamamoto M, Murakami M, Hirohashi M, Oyabu T, Myojo T, Nishi K, Kadoya C, Yamasaki S, Nagatomo H, Fujita K, Endoh S, Uchida K, Yamamoto K, Kobayashi N, Nakanishi J, Tanaka I (2010) Expression of inflammation-related cytokines following intratracheal instillation of nickel oxide nanoparticles. Nanotoxicology 4(2):161–176.  https://doi.org/10.3109/17435390903518479CrossRefPubMedGoogle Scholar
  107. Muller T, Vieira RP, Grimm M, Durk T, Cicko S, Zeiser R, Jakob T, Martin SF, Blumenthal B, Sorichter S, Ferrari D, Di Virgillio F, Idzko M (2011) A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol 44(4):456–464.  https://doi.org/10.1165/rcmb.2010-0129OCCrossRefPubMedGoogle Scholar
  108. Munoz-Planillo R, Franchi L, Miller LS, Nunez G (2009) A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome. J Immunol 183(6):3942–3948.  https://doi.org/10.4049/jimmunol.0900729CrossRefPubMedPubMedCentralGoogle Scholar
  109. Nakae S, Komiyama Y, Yokoyama H, Nambu A, Umeda M, Iwase M, Homma I, Sudo K, Horai R, Asano M, Iwakura Y (2003) IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol 15(4):483–490CrossRefPubMedGoogle Scholar
  110. Nakatani-Okuda A, Ueda H, Kashiwamura S, Sekiyama A, Kubota A, Fujita Y, Adachi S, Tsuji Y, Tanizawa T, Okamura H (2005) Protection against bleomycin-induced lung injury by IL-18 in mice. Am J Physiol Lung Cell Mol Physiol 289(2):L280–L287.  https://doi.org/10.1152/ajplung.00380.2004CrossRefPubMedGoogle Scholar
  111. Narimanbekov IO, Rozycki HJ (1995) Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in a rabbit model. Exp Lung Res 21(2):239–254CrossRefPubMedGoogle Scholar
  112. Netea MG, Selzman CH, Kullberg BJ, Galama JM, Weinberg A, Stalenhoef AF, Van der Meer JW, Dinarello CA (2000) Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells. Eur J Immunol 30(2):541–549.  https://doi.org/10.1002/1521-4141(200002)30:2<541::aid-immu541>3.0.co;2-xCrossRefPubMedGoogle Scholar
  113. Netea MG, Kullberg BJ, Jacobs LE, Verver-Jansen TJ, van der Ven-Jongekrijg J, Galama JM, Stalenhoef AF, Dinarello CA, Van der Meer JW (2004) Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release. J Immunol 173(2):1477–1482CrossRefPubMedGoogle Scholar
  114. Pacheco KA, Tarkowski M, Sterritt C, Negri J, Rosenwasser LJ, Borish L (2001) The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-beta and IL-1 beta. Clin Exp Immunol 126(3):374–383CrossRefPubMedPubMedCentralGoogle Scholar
  115. Pan LH, Ohtani H, Yamauchi K, Nagura H (1996) Co-expression of TNF alpha and IL-1 beta in human acute pulmonary fibrotic diseases: an immunohistochemical analysis. Pathol Int 46(2):91–99CrossRefPubMedGoogle Scholar
  116. Patankar YR, Lovewell RR, Poynter ME, Jyot J, Kazmierczak BI, Berwin B (2013) Flagellar motility is a key determinant of the magnitude of the inflammasome response to Pseudomonas aeruginosa. Infect Immun 81(6):2043–2052.  https://doi.org/10.1128/iai.00054-13CrossRefPubMedPubMedCentralGoogle Scholar
  117. Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG (2011) Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD. Eur Respir J 38(5):1019–1028.  https://doi.org/10.1183/09031936.00158110CrossRefPubMedGoogle Scholar
  118. Peeters PM, Perkins TN, Wouters EF, Mossman BT, Reynaert NL (2013) Silica induces NLRP3 inflammasome activation in human lung epithelial cells. Part Fibre Toxicol 10:3.  https://doi.org/10.1186/1743-8977-10-3CrossRefPubMedPubMedCentralGoogle Scholar
  119. Pereira MS, Marques GG, Dellama JE, Zamboni DS (2011a) The Nlrc4 inflammasome contributes to restriction of pulmonary infection by flagellated Legionella spp. that trigger pyroptosis. Front Microbiol 2:33.  https://doi.org/10.3389/fmicb.2011.00033CrossRefPubMedPubMedCentralGoogle Scholar
  120. Pereira MS, Morgantetti GF, Massis LM, Horta CV, Hori JI, Zamboni DS (2011b) Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo. J Immunol 187(12):6447–6455.  https://doi.org/10.4049/jimmunol.1003784CrossRefPubMedGoogle Scholar
  121. Perkins RC, Scheule RK, Hamilton R, Gomes G, Freidman G, Holian A (1993) Human alveolar macrophage cytokine release in response to in vitro and in vivo asbestos exposure. Exp Lung Res 19(1):55–65CrossRefPubMedGoogle Scholar
  122. Piguet PF, Vesin C, Grau GE, Thompson RC (1993) Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine 5(1):57–61CrossRefPubMedGoogle Scholar
  123. Pirhonen J, Sareneva T, Kurimoto M, Julkunen I, Matikainen S (1999) Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol 162(12):7322–7329PubMedGoogle Scholar
  124. Provoost S, Maes T, Pauwels NS, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Tournoy KG (2011) NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation. J Immunol 187(6):3331–3337.  https://doi.org/10.4049/jimmunol.1004062CrossRefPubMedGoogle Scholar
  125. Pugin J, Ricou B, Steinberg KP, Suter PM, Martin TR (1996) Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Respir Crit Care Med 153(6 Pt 1):1850–1856.  https://doi.org/10.1164/ajrccm.153.6.8665045CrossRefPubMedGoogle Scholar
  126. Qureshi MH, Zhang T, Koguchi Y, Nakashima K, Okamura H, Kurimoto M, Kawakami K (1999) Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans. Eur J Immunol 29(2):643–649. https://doi.org/10.1002/(sici)1521-4141(199902)29:02&#60;643::aid-immu643&#62;3.0.co;2-eCrossRefPubMedGoogle Scholar
  127. Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282(1):54–61CrossRefPubMedGoogle Scholar
  128. Reiniger N, Lee MM, Coleman FT, Ray C, Golan DE, Pier GB (2007) Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun 75(4):1598–1608.  https://doi.org/10.1128/iai.01980-06CrossRefPubMedPubMedCentralGoogle Scholar
  129. Reisetter AC, Stebounova LV, Baltrusaitis J, Powers L, Gupta A, Grassian VH, Monick MM (2011) Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles. J Biol Chem 286(24):21844–21852.  https://doi.org/10.1074/jbc.M111.238519CrossRefPubMedPubMedCentralGoogle Scholar
  130. Ren K, Torres R (2009) Role of interleukin-1beta during pain and inflammation. Brain Res Rev 60(1):57–64.  https://doi.org/10.1016/j.brainresrev.2008.12.020CrossRefPubMedGoogle Scholar
  131. Ricard JD, Dreyfuss D, Saumon G (2001) Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am J Respir Crit Care Med 163(5):1176–1180.  https://doi.org/10.1164/ajrccm.163.5.2006053CrossRefPubMedGoogle Scholar
  132. Rich PB, Douillet CD, Mahler SA, Husain SA, Boucher RC (2003) Adenosine triphosphate is released during injurious mechanical ventilation and contributes to lung edema. J Trauma 55(2):290–297.  https://doi.org/10.1097/01.ta.0000078882.11919.afCrossRefPubMedGoogle Scholar
  133. Riha RL, Yang IA, Rabnott GC, Tunnicliffe AM, Fong KM, Zimmerman PV (2004) Cytokine gene polymorphisms in idiopathic pulmonary fibrosis. Intern Med J 34(3):126–129.  https://doi.org/10.1111/j.1444-0903.2004.00503.xCrossRefPubMedGoogle Scholar
  134. Rimessi A, Bezzerri V, Patergnani S, Marchi S, Cabrini G, Pinton P (2015) Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis. Nat Commun 6:6201.  https://doi.org/10.1038/ncomms7201CrossRefPubMedGoogle Scholar
  135. Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, Ryffel B, Couillin I (2010) Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 182(6):774–783.  https://doi.org/10.1164/rccm.201003-0359OCCrossRefPubMedGoogle Scholar
  136. Riteau N, Baron L, Villeret B, Guillou N, Savigny F, Ryffel B, Rassendren F, Le Bert M, Gombault A, Couillin I (2012) ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation. Cell Death Dis 3:e403.  https://doi.org/10.1038/cddis.2012.144CrossRefPubMedPubMedCentralGoogle Scholar
  137. Rotta Detto Loria J, Rohmann K, Droemann D, Kujath P, Rupp J, Goldmann T, Dalhoff K (2013) Nontypeable Haemophilus influenzae infection upregulates the NLRP3 inflammasome and leads to caspase-1-dependent secretion of interleukin-1beta – a possible pathway of exacerbations in COPD. PLoS One 8(6):e66818.  https://doi.org/10.1371/journal.pone.0066818CrossRefPubMedPubMedCentralGoogle Scholar
  138. Rovina N, Dima E, Gerassimou C, Kollintza A, Gratziou C, Roussos C (2009) Interleukin-18 in induced sputum: association with lung function in chronic obstructive pulmonary disease. Respir Med 103(7):1056–1062.  https://doi.org/10.1016/j.rmed.2009.01.011CrossRefPubMedGoogle Scholar
  139. Rupp J, Kothe H, Mueller A, Maass M, Dalhoff K (2003) Imbalanced secretion of IL-1beta and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients. Eur Respir J 22(2):274–279CrossRefPubMedGoogle Scholar
  140. Said-Sadier N, Padilla E, Langsley G, Ojcius DM (2010) Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. PLoS One 5(4):e10008.  https://doi.org/10.1371/journal.pone.0010008CrossRefPubMedPubMedCentralGoogle Scholar
  141. Sareneva T, Matikainen S, Kurimoto M, Julkunen I (1998) Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J Immunol 160(12):6032–6038PubMedGoogle Scholar
  142. Sauty A, Mauel J, Philippeaux MM, Leuenberger P (1994) Cytostatic activity of alveolar macrophages from smokers and nonsmokers: role of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha. Am J Respir Cell Mol Biol 11(5):631–637.  https://doi.org/10.1165/ajrcmb.11.5.7946392CrossRefPubMedGoogle Scholar
  143. Scheule RK, Perkins RC, Hamilton R, Holian A (1992) Bleomycin stimulation of cytokine secretion by the human alveolar macrophage. Am J Phys 262(4 Pt 1):L386–L391Google Scholar
  144. Schmitz N, Kurrer M, Kopf M (2003) The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur J Immunol 33(4):991–1000.  https://doi.org/10.1002/eji.200323801CrossRefPubMedGoogle Scholar
  145. Schmitz N, Kurrer M, Bachmann MF, Kopf M (2005) Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol 79(10):6441–6448.  https://doi.org/10.1128/jvi.79.10.6441-6448.2005CrossRefPubMedPubMedCentralGoogle Scholar
  146. Sedimbi SK, Hagglof T, Karlsson MC (2013) IL-18 in inflammatory and autoimmune disease. Cell Mol Life Sci CMLS 70(24):4795–4808.  https://doi.org/10.1007/s00018-013-1425-yCrossRefPubMedGoogle Scholar
  147. Shaikh PZ (2011) Cytokines & their physiologic and pharmacologic functions in inflammation: a review. Int J Pharm Life Sci 2(10):1247–1263Google Scholar
  148. Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M (2011) Caspase-1 dependent IL-1beta secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One 6(6):e21477.  https://doi.org/10.1371/journal.pone.0021477CrossRefPubMedPubMedCentralGoogle Scholar
  149. Shimokata K, Saka H, Murate T, Hasegawa Y, Hasegawa T (1991) Cytokine content in pleural effusion. Comparison between tuberculous and carcinomatous pleurisy. Chest 99(5):1103–1107CrossRefPubMedGoogle Scholar
  150. Silveira TN, Zamboni DS (2010) Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis. Infect Immun 78(3):1403–1413.  https://doi.org/10.1128/iai.00905-09CrossRefPubMedPubMedCentralGoogle Scholar
  151. Simitsopoulou M, Roilides E, Likartsis C, Ioannidis J, Orfanou A, Paliogianni F, Walsh TJ (2007) Expression of immunomodulatory genes in human monocytes induced by voriconazole in the presence of Aspergillus fumigatus. Antimicrob Agents Chemother 51(3):1048–1054.  https://doi.org/10.1128/aac.01095-06CrossRefPubMedGoogle Scholar
  152. Sousa AR, Lane SJ, Nakhosteen JA, Lee TH, Poston RN (1996) Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium. Am J Respir Crit Care Med 154(4 Pt 1):1061–1066.  https://doi.org/10.1164/ajrccm.154.4.8887608CrossRefPubMedGoogle Scholar
  153. Srivastava KD, Rom WN, Jagirdar J, Yie TA, Gordon T, Tchou-Wong KM (2002) Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice. Am J Respir Crit Care Med 165(4):527–533.  https://doi.org/10.1164/ajrccm.165.4.2106009CrossRefPubMedGoogle Scholar
  154. Stasakova J, Ferko B, Kittel C, Sereinig S, Romanova J, Katinger H, Egorov A (2005) Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. J Gen Virol 86(Pt 1):185–195.  https://doi.org/10.1099/vir.0.80422-0CrossRefPubMedGoogle Scholar
  155. Sugawara I, Yamada H, Kaneko H, Mizuno S, Takeda K, Akira S (1999) Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect Immun 67(5):2585–2589PubMedPubMedCentralGoogle Scholar
  156. Sugawara I, Yamada H, Hua S, Mizuno S (2001) Role of interleukin (IL)-1 type 1 receptor in mycobacterial infection. Microbiol Immunol 45(11):743–750CrossRefPubMedGoogle Scholar
  157. Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA (2007) Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med 204(13):3235–3245.  https://doi.org/10.1084/jem.20071239CrossRefPubMedPubMedCentralGoogle Scholar
  158. Thomas SS, Chhabra SK (2003) A study on the serum levels of interleukin-1beta in bronchial asthma. J Indian Med Assoc 101(5):282, 284, 286 passimGoogle Scholar
  159. Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD (2009) The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30(4):566–575.  https://doi.org/10.1016/j.immuni.2009.02.006CrossRefPubMedPubMedCentralGoogle Scholar
  160. Tillie-Leblond I, Pugin J, Marquette CH, Lamblin C, Saulnier F, Brichet A, Wallaert B, Tonnel AB, Gosset P (1999) Balance between proinflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus. Am J Respir Crit Care Med 159(2):487–494.  https://doi.org/10.1164/ajrccm.159.2.9805115CrossRefPubMedGoogle Scholar
  161. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Invest 99(5):944–952.  https://doi.org/10.1172/jci119259CrossRefPubMedPubMedCentralGoogle Scholar
  162. Tsao TC, Hong J, Li LF, Hsieh MJ, Liao SK, Chang KS (2000) Imbalances between tumor necrosis factor-alpha and its soluble receptor forms, and interleukin-1beta and interleukin-1 receptor antagonist in BAL fluid of cavitary pulmonary tuberculosis. Chest 117(1):103–109CrossRefPubMedGoogle Scholar
  163. Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E (2013) Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal 18(14):1753–1764.  https://doi.org/10.1089/ars.2012.4799CrossRefPubMedPubMedCentralGoogle Scholar
  164. Wang CC, Fu CL, Yang YH, Lo YC, Wang LC, Chuang YH, Chang DM, Chiang BL (2006) Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther 13(19):1414–1421.  https://doi.org/10.1038/sj.gt.3302798CrossRefPubMedGoogle Scholar
  165. Whyte M, Hubbard R, Meliconi R, Whidborne M, Eaton V, Bingle C, Timms J, Duff G, Facchini A, Pacilli A, Fabbri M, Hall I, Britton J, Johnston I, Di Giovine F (2000) Increased risk of fibrosing alveolitis associated with interleukin-1 receptor antagonist and tumor necrosis factor-alpha gene polymorphisms. Am J Respir Crit Care Med 162(2 Pt 1):755–758.  https://doi.org/10.1164/ajrccm.162.2.9909053CrossRefPubMedGoogle Scholar
  166. Wilkinson RJ, Patel P, Llewelyn M, Hirsch CS, Pasvol G, Snounou G, Davidson RN, Toossi Z (1999) Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis. J Exp Med 189(12):1863–1874CrossRefPubMedPubMedCentralGoogle Scholar
  167. Willingham SB, Allen IC, Bergstralh DT, Brickey WJ, Huang MT, Taxman DJ, Duncan JA, Ting JP (2009) NLRP3 (NALP3, Cryopyrin) facilitates in vivo caspase-1 activation, necrosis, and HMGB1 release via inflammasome-dependent and -independent pathways. J Immunol 183(3):2008–2015.  https://doi.org/10.4049/jimmunol.0900138CrossRefPubMedPubMedCentralGoogle Scholar
  168. Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA (2010) Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med 207(3):535–552.  https://doi.org/10.1084/jem.20092121CrossRefPubMedPubMedCentralGoogle Scholar
  169. Witzenrath M, Pache F, Lorenz D, Koppe U, Gutbier B, Tabeling C, Reppe K, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B (2011) The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol 187(1):434–440.  https://doi.org/10.4049/jimmunol.1003143CrossRefPubMedGoogle Scholar
  170. Wolk KE, Lazarowski ER, Traylor ZP, Yu EN, Jewell NA, Durbin RK, Durbin JE, Davis IC (2008) Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. Am J Respir Crit Care Med 178(9):969–976.  https://doi.org/10.1164/rccm.200803-455OCCrossRefPubMedPubMedCentralGoogle Scholar
  171. Wrigge H, Zinserling J, Stuber F, von Spiegel T, Hering R, Wetegrove S, Hoeft A, Putensen C (2000) Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function. Anesthesiology 93(6):1413–1417CrossRefPubMedGoogle Scholar
  172. Wu J, Yan Z, Schwartz DE, Yu J, Malik AB, Hu G (2013) Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury. J Immunol 190(7):3590–3599.  https://doi.org/10.4049/jimmunol.1200860CrossRefPubMedPubMedCentralGoogle Scholar
  173. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, Fan J (2011) Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol 187(9):4809–4817.  https://doi.org/10.4049/jimmunol.1102093CrossRefPubMedPubMedCentralGoogle Scholar
  174. Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D’Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM (2012) Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 185(5):547–556.  https://doi.org/10.1164/rccm.201108-1574OCCrossRefPubMedPubMedCentralGoogle Scholar
  175. Xu P, Wen Z, Shi X, Li Y, Fan L, Xiang M, Li A, Scott MJ, Xiao G, Li S, Billiar TR, Wilson MA, Fan J (2013) Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. J Immunol 190(10):5247–5255.  https://doi.org/10.4049/jimmunol.1203182CrossRefPubMedPubMedCentralGoogle Scholar
  176. Yamada H, Mizumo S, Horai R, Iwakura Y, Sugawara I (2000) Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice. Lab Investig 80(5):759–767CrossRefPubMedGoogle Scholar
  177. Yang HM, Ma JY, Castranova V, Ma JK (1997) Effects of diesel exhaust particles on the release of interleukin-1 and tumor necrosis factor-alpha from rat alveolar macrophages. Exp Lung Res 23(3):269–284.  https://doi.org/10.3109/01902149709087372CrossRefPubMedGoogle Scholar
  178. Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J (2010) Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta. Proc Natl Acad Sci U S A 107(45):19449–19454.  https://doi.org/10.1073/pnas.1008155107CrossRefPubMedPubMedCentralGoogle Scholar
  179. Yucesoy B, Vallyathan V, Landsittel DP, Sharp DS, Weston A, Burleson GR, Simeonova P, McKinstry M, Luster MI (2001) Association of tumor necrosis factor-alpha and interleukin-1 gene polymorphisms with silicosis. Toxicol Appl Pharmacol 172(1):75–82.  https://doi.org/10.1006/taap.2001.9124CrossRefPubMedGoogle Scholar
  180. Zhang Y, Lee TC, Guillemin B, Yu MC, Rom WN (1993) Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J Immunol 150(9):4188–4196PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Fengying Xu
    • 1
    • 4
  • Zongmei Wen
    • 2
  • Xueying Shi
    • 3
  • Jie Fan
    • 4
    • 5
  1. 1.Department of AnesthesiologyNo. 401 HospitalQingdaoChina
  2. 2.Department of Anesthesiology, Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina
  3. 3.Department of Anesthesiology and Critical Care, Shanghai Xinghua HospitalJiaotong University School of MedicineShanghaiChina
  4. 4.Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA
  5. 5.Research and Development, Veterans Affairs Pittsburgh Healthcare SystemPittsburghUSA

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