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Lung Diseases

  • Saleela M. Ruwanpura
  • Sarah Rosli
  • Michelle D. Tate
Chapter
Part of the Experientia Supplementum book series (EXS, volume 108)

Abstract

Inflammasomes are large innate cytoplasmic complexes that play a major role in promoting inflammation in the lung in response to a range of environmental and infectious stimuli. Inflammasomes are critical for driving acute innate immune responses that resolve infection and maintain tissue homeostasis. However, dysregulated or excessive inflammasome activation can be detrimental. Here, we discuss the plethora of recent data from clinical studies and small animal disease models that implicate excessive inflammasome responses in the pathogenesis of a number of acute and chronic respiratory inflammatory diseases. Understanding of the role of inflammasomes in lung disease is of great therapeutic interest.

Keywords

Inflammasomes Lung disease Inflammation Disease pathogenesis 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Saleela M. Ruwanpura
    • 1
    • 2
  • Sarah Rosli
    • 1
    • 2
  • Michelle D. Tate
    • 1
    • 2
  1. 1.Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical ResearchClaytonAustralia
  2. 2.Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health SciencesMonash UniversityClaytonAustralia

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