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Inflammasomes in Bone Diseases

  • Gabriel Mbalaviele
  • Deborah J. Veis
Chapter
Part of the Experientia Supplementum book series (EXS, volume 108)

Abstract

Unresolved inflammation is harmful to any tissues in the organism. Bone in particular is vulnerable to inflammatory assaults because its integrity depends on the activity of osteoclasts, which arise from myeloid precursors. Osteoclasts are responsible for bone resorption in normal and disease conditions. Increased osteolysis is a common feature of inflammatory disorders and a risk factor for bone fractures. Thus, bone is impacted negatively not only by local and systemic inflammatory mediators, but also directly, by alterations affecting myelopoiesis and lineage allocations. Such perturbations are characteristics of dysregulated inflammasomes, which are key regulators of innate immunity. In this review, we discuss the role of inflammasomes in bone diseases caused by sterile or non-sterile inflammation.

Keywords

Inflammation Inflammasome NLRP3 PARP1 Osteoclast Bone DAMPs PAMPs IL-1 Infection 

Notes

Acknowledgments and Conflict of Interest

G.M. is supported by NIH/NIAMS AR064755 and AR068972 grants and is co-founder of Confluence Life Sciences, Inc. D.J.V is supported by NIH/NIAMS AR070030 and the Shriners Hospitals for Children.

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Authors and Affiliations

  1. 1.Division of Bone and Mineral Diseases, Department of MedicineWashington University School of MedicineSt. LouisUSA
  2. 2.Division of Anatomic and Molecular Pathology, Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA

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