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Role of Inflammasomes in the Development of Gastrointestinal Diseases

  • Mazhar A. Kanak
  • Yoshitaro Shindo
  • Pavithra SaiKumar
  • Bashoo Naziruddin
Chapter
Part of the Experientia Supplementum book series (EXS, volume 108)

Abstract

Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intracellular proteins that link the sensing of microbial products and metabolic stress to the proteolytic activation of the proinflammatory cytokines. Recent studies have implicated activation of several families of NOD-like receptors (NLRs) which are major components of inflammasomes in the development and exacerbation of many diseases of human systems. In this chapter, we discuss the role of inflammasomes in some of the most prevalent diseases of the gastrointestinal tract and highlight potential targets for treatment.

Keywords

Inflammasome Gastritis Gastric cancer Inflammatory bowel disease Colorectal cancer Fatty liver disease Hepatitis Liver cirrhosis Hepatocellular carcinoma Pancreatitis Pancreatic cancer 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mazhar A. Kanak
    • 1
  • Yoshitaro Shindo
    • 1
  • Pavithra SaiKumar
    • 2
  • Bashoo Naziruddin
    • 3
  1. 1.Division of Transplantation, Department of SurgeryVirginia Commonwealth University Medical CenterRichmondUSA
  2. 2.AcicSan FranciscoUSA
  3. 3.Sammons Cancer Center, Baylor Simmons Transplant InstituteDallasUSA

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