Based on the results of a few small, but extremely valuable, case-series studies on the natural history of gastric cardiac carcinoma in China and Japan, gastric cardiac carcinoma is a slow-progressive malignant neoplasm, taking 2–6 years to progress from intramucosa to submucosa. However, once invading into the muscularis propria, the tumor becomes much more aggressive. Therefore, the patient management may need to be individualized, according to the specific stage of the disease.
Gastric cardiac carcinoma Stomach Natural history Cancer Early gastric carcinoma
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