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Epidemiology and Risk Factors

  • Qin Huang
  • Edward Lew
Chapter

Abstract

The high-quality evidence on epidemiology of gastric cardiac carcinoma in recent decades suggests a rising incidence in East Asian countries but not so in Western countries. However, risk factors of gastric cardiac carcinoma remain elusive and are not the same as those of esophageal or distal gastric non-cardiac carcinomas, although some single-center studies show the evidence for aging, obesity, environmental toxin, and history of cancer, especially esophageal cancer, as the potential independent risk factors, which remains to be validated.

Keywords

Gastric cardiac carcinoma Stomach Cancer Epidemiology Aging Obesity Environmental toxin 

References

  1. 1.
    Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 [Online]. http://globocan.iarc.fr. Accessed on 11/18/2016.
  3. 3.
    Crew KD, Neugut AI. Epidemiology of upper gastrointestinal malignancy. Semin Oncol. 2004;31:450–64.CrossRefPubMedGoogle Scholar
  4. 4.
    Chen W, Zheng R, Zhang S, et al. Report of incidence and mortality in China cancer registries, 2009. Chin J Cancer Res. 2013;25:10–21.PubMedPubMedCentralGoogle Scholar
  5. 5.
    de Martel C, Forman D, Plummer M. Gastric cancer: epidemiology and risk factors. Gastroenterol Clin North Am. 2013;42:219–40.CrossRefPubMedGoogle Scholar
  6. 6.
    National Cancer Institute. http://www.cancer.gov/types/stomach/hp/stomach-treatment-pdq#link/_163_toc. Accessed on 6/7/2015.
  7. 7.
    Wu H, Rusiecki JA, Zhu K, Potter J, Devesa SS. Stomach carcinoma incidence patterns in the United States by histologic type and anatomic site. Cancer Epidemiol Biomarkers Prev. 2009;18:1945–52.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Son JI, Park HJ, Song KS, et al. A single center’s 30 years’ experience of esophageal adenocarcinoma. Korean J Intern Med. 2001;16:250–3.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Yee YK, Cheung TK, Chan AO, Yuen MF, Wong BC. Decreasing trend of esophageal adenocarcinoma in Hong Kong. Cancer Epidemiol Biomarkers Prev. 2007;16:2637–40.CrossRefPubMedGoogle Scholar
  10. 10.
    Fang WL, Wu CW, Chen JH, et al. Esophagogastric junction adenocarcinoma according to Siewert classification in Taiwan. Ann Surg Oncol. 2009;16:3237–44.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Matsueda K, Manabe N, Sato Y, et al. Adenocarcinoma of the esophagogastric junction is still low in Japan—multicenter epidemiological study in Kurashiki, Japan. Gastroenterology. 2015;148(4 Suppl 1):S-764.CrossRefGoogle Scholar
  12. 12.
    Dubecz A, Solymosi N, Stadlhuber RJ, Schweigert M, Stein HJ, Peters JH. Does the incidence of adenocarcinoma of the esophagus and gastric cardia continue to rise in the twenty-first century?—a SEER database analysis. J Gastrointest Surg. 2014;18:124–9.CrossRefGoogle Scholar
  13. 13.
    Coupland VH, Lagergren J, Konfortion J, et al. Ethnicity in relation to incidence of oesophageal and gastric cancer in England. Br J Cancer. 2012;107:1908–14.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Dikken JL, Lemmens VE, Wouters MW, et al. Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. Eur J Cancer. 2012;48:1624–32.CrossRefPubMedGoogle Scholar
  15. 15.
    Schmassmann A, Oldendorf MG, Gebbers JO. Changing incidence of gastric and oesophageal cancer subtypes in central Switzerland between 1982 and 2007. Eur J Epidemiol. 2009;24:603–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Hansen S, Wiig JN, Giercksky KE, Tretli S. Esophageal and gastric carcinoma in Norway 1958-1992: incidence time trend variability according to morphological subtypes and organ subsites. Int J Cancer. 1997;71:340–4.CrossRefPubMedGoogle Scholar
  17. 17.
    Orengo MA, Casella C, Fontana V, et al. Trends in incidence rates of oesophagus and gastric cancer in Italy by subsite and histology, 1986-1997. Eur J Gastroenterol Hepatol. 2006;18:739–46.CrossRefPubMedGoogle Scholar
  18. 18.
    He YT, Hou J, Chen ZF, et al. Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. Eur J Cancer Prev. 2008;17:71–6.CrossRefPubMedGoogle Scholar
  19. 19.
    Shi J, Sun Q, Xu BY, et al. Changing trends in proportions of small (≤ 2 cm) proximal and non-proximal gastric carcinomas treated at a high-volume tertiary medical center in China. J Dig Dis. 2014;15:359–66.CrossRefPubMedGoogle Scholar
  20. 20.
    Park JC, Lee YC, Kim JH, et al. Clinicopathological features and prognostic factors of proximal gastric carcinoma in a population with high Helicobacter pylori prevalence: a single-center, large-volume study in Korea. Ann Surg Oncol. 2010;17:829–37.CrossRefPubMedGoogle Scholar
  21. 21.
    Deans C, Yeo MS, Soe MY, Shabbir A, Ti TK, So JB. Cancer of the gastric cardia is rising in incidence in an Asian population and is associated with adverse outcome. World J Surg. 2011;35:617–24.CrossRefPubMedGoogle Scholar
  22. 22.
    Bashash M, Shah A, Hislop G, Brooks-Wilson A, Le N, Bajdik C. Incidence and survival for gastric and esophageal cancer diagnosed in British Columbia, 1990 to 1999. Can J Gastroenterol. 2008;22:143–8.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Blaser MJ, Saito D. Trends in reported adenocarcinomas of the oesophagus and gastric cardia in Japan. Eur J Gastroenterol Hepatol. 2002;14:107–13.CrossRefPubMedGoogle Scholar
  24. 24.
    Liu Y, Kaneko S, Sobue T. Trends in reported incidences of gastric cancer by tumour location, from 1975 to 1989 in Japan. Int J Epidemiol. 2004;33:808–15.CrossRefPubMedGoogle Scholar
  25. 25.
    Ekström AM, Signorello LB, Hansson LE, et al. Evaluating gastric cancer misclassification: a potential explanation for the rise in cardia cancer incidence. J Natl Cancer Inst. 1999;91:786–90.CrossRefPubMedGoogle Scholar
  26. 26.
    Huang Q, Shi J, Sun Q, et al. Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Hum Pathol. 2012;43:2138–48.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Suh YS, Han DS, Kong SH, et al. Should adenocarcinoma of the esophagogastric junction be classified as esophageal cancer? A comparative analysis according to the seventh AJCC TNM classification. Ann Surg. 2012;255(5):908–15.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    El-Serag HB, Mason AC, Petersen N, Key CR. Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA. Gut. 2002;50:368–72.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Maeda H, Okabayashi T, Nishimori I, et al. Clinicopathologic features of adenocarcinoma at the gastric cardia: is it different from distal cancer of the stomach? J Am Coll Surg. 2008;206:306–10.CrossRefPubMedGoogle Scholar
  30. 30.
    Okabayashi T, Gotoda T, Kondo H, et al. Early carcinoma of the gastric cardia in Japan: is it different from that in the West? Cancer. 2000;89:2555–9.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Kim JY, Lee HS, Kim N, et al. Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea. Helicobacter. 2012;17:358–68.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Fang C, Lu L, Shi J, et al. Risk factors of early proximal gastric carcinoma in Chinese diagnosed with the WHO criteria. J Dig Dis. 2015;16:327–36.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Amini N, Spolverato G, Kim Y, et al. Clinicopathological features and prognosis of gastric cardia adenocarcinoma: a multi-institutional US study. J Surg Oncol. 2015;111:285–92.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Huang Q, Fan XS, Agoston AT, et al. Comparison of gastroesophageal junction carcinomas in Chinese versus American patients. Histopathology. 2011;59:188–97.CrossRefPubMedGoogle Scholar
  35. 35.
    Carneiro F, Moutinho C, Pera G, et al. Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC/EUR-GAST). Scand J Gastroenterol. 2007;42:618–27.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Bytzer P, Christensen PB, Damkier P, Vinding K, Seersholm N. Adenocarcinoma of the esophagus and Barrett’s esophagus: a population-based study. Am J Gastroenterol. 1999;94:86–91.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol. 2006;12:354–62.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Kubo A, Corley DA. Marked multi-ethnic variation of esophageal and gastric cardia carcinomas within the United States. Am J Gastroenterol. 2004;99:582–8.CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Shim JH, Song KY, Jeon HM, et al. Is gastric cancer different in Korea and the United States? Impact of tumor location on prognosis. Ann Surg Oncol. 2014;21:2332–9.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Rogers EL, Goldkind SF, Iseri OA, et al. Adenocarcinoma of the lower esophagus. A disease primarily of white men with Barrett’s esophagus. J Clin Gastroenterol. 1986;8:613–8.CrossRefPubMedGoogle Scholar
  41. 41.
    Wu AH, Wan P, Bernstein L. A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States). Cancer Causes Control. 2001;12:721–32.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Ladeiras-Lopes R, Pereira AK, Nogueira A, et al. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008;19:689–701.CrossRefPubMedGoogle Scholar
  43. 43.
    González CA, Pera G, Agudo A, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Int J Cancer. 2003;107:629–34.CrossRefPubMedGoogle Scholar
  44. 44.
    Sun CQ, Chang YB, Cui LL, et al. A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou. Asian Pac J Cancer Prev. 2013;14:2897–901.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Tong GX, Liang H, Chai J, et al. Association of risk of gastric cancer and consumption of tobacco, alcohol and tea in the Chinese population. Asian Pac J Cancer Prev. 2014;15:8765–74.CrossRefPubMedGoogle Scholar
  46. 46.
    Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 2001;49:347–53.CrossRefGoogle Scholar
  47. 47.
    Huang Q, Shi J, Sun Q, et al. Clinicopathologic characterization of small (≤ 2 cm) proximal and distal gastric carcinomas in a Chinese population. Pathology. 2015;47(6):526–32.CrossRefPubMedPubMedCentralGoogle Scholar
  48. 48.
    Carr JS, Zafar SF, Saba N, Khuri FR, El-Rayes BF. Risk factors for rising incidence of esophageal and gastric cardia adenocarcinoma. J Gastrointest Cancer. 2013;44:143–51.CrossRefPubMedGoogle Scholar
  49. 49.
    Lagergren J, Bergstrom R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340:825–31.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Nguyen TH, Thrift AP, Ramsey D, et al. Risk factors for Barrett’s esophagus compared between African Americans and non-Hispanic Whites. Am J Gastroenterol. 2014;109:1870–80.CrossRefPubMedGoogle Scholar
  51. 51.
    Kubo A, Corley DA. Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:872–8.CrossRefPubMedGoogle Scholar
  52. 52.
    Lindblad M, Rodriguez LA, Lagergren J. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control. 2005;16:285–94.CrossRefPubMedGoogle Scholar
  53. 53.
    Lin XJ, Wang CP, Liu XD, et al. Body mass index and risk of gastric cancer: a meta-analysis. Jpn J Clin Oncol. 2014;44(9):783–91.CrossRefPubMedGoogle Scholar
  54. 54.
    Guggenheim DE, Shah MA. Gastric cancer epidemiology and risk factors. J Surg Oncol. 2013;107:230–6.CrossRefPubMedGoogle Scholar
  55. 55.
    Kubo A, Corley DA. Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma. Am J Gastroenterol. 2007;102:2323–30.CrossRefPubMedGoogle Scholar
  56. 56.
    Jiang X, Tseng CC, Bernstein L, Wu AH. Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case-control study. BMC Cancer. 2014;14:60.CrossRefPubMedPubMedCentralGoogle Scholar
  57. 57.
    Inoue M, Tajima K, Yamamura Y, et al. Family history and subsite of gastric cancer: data from a case-referent study in Japan. Int J Cancer. 1998;76:801–5.CrossRefPubMedGoogle Scholar
  58. 58.
    Chen J, Li XM, Zhou FY, et al. Comparative analysis on histopathological changes at gastric body and antrum of monozygotic and dizygotic twins from esophageal and cardiac cancer high-incidence area in Henan. J Zhengzhou Univ (Med Sci). 2012;47:619–21. (In Chinese).Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Qin Huang
    • 1
    • 2
  • Edward Lew
    • 3
  1. 1.Pathology and Laboratory MedicineVeterans Affairs Boston Healthcare SystemWest RoxburyUSA
  2. 2.Harvard Medical School and Brigham and Women’s HospitalBostonUSA
  3. 3.Harvard Medical School, VA Boston Healthcare System and Brigham and Women’s HospitalBostonUSA

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