Diagnostic Meta-Analysis: Case Study in Gastroenterology

  • Bashar J. Qumseya
  • Michael WallaceEmail author


Meta-analysis refers to the use of statistical tools to combine and compare the results of multiple studies on particular outcomes on interest. Use of meta-analysis in the medical literature, including the field of gastroenterology, has been increasing. Conducting high-quality meta-analysis can be challenging. Similarly understanding published meta-analyses can be difficult. In this chapter, we will present several case studies on meta-analyses in gastroenterology. We will use these studies to shed light on several key factors in meta-analyses. These factors include the importance of choosing the appropriate inclusion and exclusion criteria, deciding on the best meta-meter of interest, recognizing and dealing with duplicate cohorts, and using direct and indirect comparisons. Our goal is to show how meta-analyses can be great tools for providing evidence-based results that can have a significant impact on clinical practice in the field of gastroenterology.


Systematic review Meta-analysis Clinical research Gastroenterology Endoscopy Epidemiology 



Advanced imaging


Barrett’s esophagus




Confidence interval


Esophageal adenocarcinoma


Endoscopic mucosal resection


Endoscopic ultrasound


High-grade dysplasia


Low-grade dysplasia




Quality Assessment of Diagnostic Accuracy Studies


Risk difference


Radiofrequency ablation


Systematic review


Virtual chromoendoscopy


White light endoscopy


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Gastroenterology and HepatologyArchbold Medical Group/Florida State UniversityThomasvilleUSA
  2. 2.Division of Gastroenterology and HepatologyMayo ClinicJacksonvilleUSA

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