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Gene Therapy in Tendon Repair and Regeneration

  • Raman Mehrzad
  • Xiao Tian Wang
  • You Lang Zhou
  • Ya Fang Wu
  • Paul Y. Liu
Chapter

Abstract

Tendon and ligament injuries constitute one of the most common traumas to the human body, with tendon injuries to the hand and wrist occurring in hundreds of thousands of people annually in the USA alone. Gene therapy for the purpose of tendon healing is used to manipulate the healing environment. In this chapter, we will define the issues with tendon injuries, the model of gene therapy, and the clinical problems that may be addressed with gene intervention.

Abbreviations

AAV

Adeno-associated virus

bFGF

Basic fibroblast growth factor

PDGF-B

Platelet-derived growth factor-B

VEGF

Vascular endothelial growth factor

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Raman Mehrzad
    • 1
  • Xiao Tian Wang
    • 1
  • You Lang Zhou
    • 2
  • Ya Fang Wu
    • 2
  • Paul Y. Liu
    • 1
  1. 1.Department of Plastic SurgeryRhode Island Hospital, The Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Department of Hand Surgery, The Hand Surgery Research CenterAffiliated Hospital of Nantong UniversityNantongChina

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