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c-MET in Head and Neck Squamous Cell Carcinoma

  • John Kaczmar
  • Tim N. Beck
Chapter
Part of the Current Cancer Research book series (CUCR)

Abstract

The kinase receptor c-MET (MET proto-oncogene, receptor tyrosine kinase; also known as the hepatocyte growth factor receptor) and its ligand hepatocyte growth factor/scatter factor (HGF/SF) are two promising, potentially therapeutically exploitable targets in head and neck squamous cell carcinoma (HNSCC). c-MET is commonly overexpressed in head and neck cancer cells compared to normal epithelial cells and HGF/SF is often detected at high expression levels in tumor-adjacent mesenchymal cells, inducing paracrine activation of c-MET to support tumor growth and proliferation. Blocking this paracrine activity has been shown to reduce the proliferative capacity of HNSCC cells. Importantly, c-MET signaling outputs intersect with those of multiple other signaling pathways that drive or otherwise contribute to HNSCC cell survival and spread, including EGFR, HER2, SRC, STAT3, PI3K, RAS, GRB2, and others. In this review, we emphasize the roles of c-MET and HGF in HNSCC as well as the potential for therapeutic targeting of this signaling axis.

Keywords

c-MET HGFR HGF/SF Head and neck cancer Squamous cell cancer Receptor tyrosine kinases Targeted therapy 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Hollings Cancer Center, Division of Hematology and Oncology, Department of MedicineMedical University of South CarolinaCharlestonUSA
  2. 2.Molecular Therapeutics ProgramFox Chase Cancer CenterPhiladelphiaUSA
  3. 3.Program in Molecular and Cell Biology and GeneticsDrexel University College of MedicinePhiladelphiaUSA

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