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Mobile Innate Immune Cells

  • Walter Gottlieb Land
Chapter

Abstract

This chapter describes the broad variety of mobile cells of the innate immune system. The cells include phagocytic cells such as monocytes/macrophages, polymorphonuclear neutrophils, and dendritic cells; cells that release inflammatory mediators such as eosinophils, basophils, and mast cells; and innate lymphoid cells such as natural killer cells as well as unconventional “non-classical” T cells with partial innate function such as natural killer T cells, mucosal-associated invariant T cells, and gammadelta T cells. These mobile innate immune cells represent the core of the immune defense system on the level of those professional cells which operate at the initial phase of infective and sterile tissue injury. Many of these cells are grouped into several subsets. Typically, these cells execute different defense functions such as phagocytic capabilities of phagocytes and killing properties of natural killer cells and unconventional T cells, all properties aimed at getting rid of inciting insults and restoring homeostasis. Another striking feature of these mobile innate immune cells is their role in preparing a robust adaptive immune response upon the presence of nonself or altered-self antigens. In this regard, one can even notice some overlapping functions between innate and adaptive immune cells. Finally, the mobile cells are also involved in the integration of the sessile cells of the innate immune system to combat injury commonly.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University of StrasbourgMolecular ImmunoRheumatology, Laboratory of Excellence TransplantexStrasbourgFrance

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