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Epilogue : Cells of Our Immune System: A Whole Army of Defenders Far Beyond T and B Cells

  • Walter Gottlieb Land
Chapter

Abstract

The Epilogue to Part III is devoted to the issue of reassessing the composition and the facilities of the mammalian immune system: originally thought to consist of T and B lymphocytes and antibodies only capable of defending our body against bacterial or viral infections, the system has now to be settled far beyond this level. Various categories of cells of our whole organism including mobile immune as well as sessile organ-specific cells are all equipped with PRMs to sense MAMPs and/or DAMPs. They do represent and operate as a whole army of defenders committed to different tasks and duties and equipped with various weapons. In terms of an admirable cooperation and collaboration, they are permanently alert to ward off any dangerous injury to our body by taking decisions on whether when and how to respond to a given injurious threat. The aim of such responses is always straightforward: to eliminate the harmful agent and to repair and remodel the injured tissue. However, if the injury is too heavy or becomes chronically repetitive or even persistent, the response may turn into an uncontrolled, exaggerated, or overshooting reaction and, thus, may lead to pathologies and diseases. In this sense, the whole family of innate immune cells will accompany the reader throughout the book.

In the second decade of the new millennium, we have to rethink when assessing the composition and the facilities of our immune system. Originally thought to consist of T and B lymphocytes and antibodies only capable of defending our body against bacterial or viral infections, we now know that the system has to be settled far beyond this level. Various categories of cells of our whole organisms as briefly addressed in this Part III of the book, including mobile immune as well as sessile organ-specific cells, are all equipped with PRMs to sense MAMPs and/or DAMPs. They do represent and operate as a whole army of defenders committed to different tasks and duties and equipped with various weapons. In terms of an admirable cooperation and collaboration, they are permanently alert to ward off any dangerous injury to our body by taking decisions on whether when and how to respond to a given injurious threat. The aim of such responses is always straightforward: to eliminate the harmful agent and to repair and remodel the injured tissue. However, if the injury is too heavy or becomes chronically repetitive or even persistent, the response may turn into an uncontrolled, exaggerated, or overshooting reaction and, thus, may lead to pathologies and diseases. In this sense, the whole family of innate immune cells will accompany the reader throughout the book.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University of StrasbourgMolecular ImmunoRheumatology, Laboratory of Excellence TransplantexStrasbourgFrance

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