Concurrent Papillary Thyroid Cancer and Medullary Thyroid Cancer
- 722 Downloads
Concurrent occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in a single patient is uncommon. The cell origin, histopathologic features, and prognosis of these two carcinomas are considered completely different. A 40-year-old man was diagnosed MTC after fine needle aspiration biopsy of the right thyroid nodule and the lymph node on the right side. The patient underwent total thyroidectomy with unilateral central compartment and right lateral neck dissection. Histopathological evaluation was identified as MTC in the nodule of the right lobe and the MTC metastasis in the lymph nodes. Besides, papillary microcarcinoma foci were determined on the same thyroid lobe. He had c.1585 > A (p.Glu529Lys) heterozygous variant mutation of RET proto-oncogene. Sixteen months after the operation, his serum calcitonin, carcinoembryonic antigen (CEA), and thyroglobulin levels are undetectable.
KeywordsMedullary thyroid carcinoma Papillary thyroid carcinoma Concurrent medullary Papillary thyroid carcinoma
- 1.Wells SA Jr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, et al. Revised American Thyroid Association guidelines for the Management of Medullary Thyroid Carcinoma: the American Thyroid Association guidelines task force on medullary thyroid carcinoma. Thyroid. 2015;25:567–610. https://doi.org/10.1089/thy.2014.0335.CrossRefPubMedPubMedCentralGoogle Scholar
- 2.Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1–133. https://doi.org/10.1089/thy.2015.0020.CrossRefPubMedPubMedCentralGoogle Scholar