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Dosimetric Approach in Metastatic Differentiated Thyroid Cancer and Hyperthyroidism

  • Haluk B. Sayman
  • Nami Yeyin
  • Mohammad Abuqbeitah
Chapter

Abstract

Radioiodine (131I) therapy has been widely used for well-differentiated thyroid cancer and its metastases for many years. Two approaches, namely, empirical dosage and dosimetry-based methods, are currently utilized to manage the therapeutic iodine activity.

Empirical dosage is based on the physician’s rating to suggest appropriate activity within a certain range of without individualized dose planning. On the other hand, dosimetry-based approach implicates effective activity administration leaning on specific activity regulated by the organs at risk.

In this report, we propose and define dosimetry-based treatment with examples of differentiated thyroid cancer and hyperthyroidism cases.

Our results indicated that the implementation of dosimetry protocol might help to administer larger amounts of activity controlled by critical organ dose limits, thereby delivering lethal dose to tumors with no toxicity. It is also well demonstrated that dosimetric approach is favorable for hyperthyroid patients in order to deliver right amount of radioiodine activity for efficient therapeutical response.

Keywords

Radioiodine Empirical Dosimetry Thyroid cancer Hyperthyroidism 

References

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    Maxon HR, Thomas SR, Hertzberg VS, Kereiakes JG, Chen IW, Sperling MI, Saenger EL. Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer. N Engl J Med. 1983;309:937–41.  https://doi.org/10.1056/NEJM198310203091601.CrossRefPubMedGoogle Scholar
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    Wessels BW, Bolch WE, Bouchet LG, Breitz HB, DeNardo GL, Meredith RF. Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: a multiinstitutional comparison. J Nucl Med. 2004;45:1725–33.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Haluk B. Sayman
    • 1
  • Nami Yeyin
    • 1
  • Mohammad Abuqbeitah
    • 1
  1. 1.Department of Nuclear MedicineCerrahpaşa Medical Faculty, Istanbul UniversityIstanbulTurkey

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