Osteogenesis Imperfecta (OI)

  • Jose M. Ramirez


Osteogenesis imperfecta is a potentially disabling disease due to increased fracture fragility and spinal involvement. The molecular causes of osteogenesis imperfecta are frequently tested.


Fractures Limb deformity Collagen 1 Bisphosphonates Blue sclera 

OI is caused by a qualitative and/or quantitative defect in what protein?

Type 1 Collagen

What medical therapy can reduce fracture rate in OI?

Bisphosphonate therapy

Signs of myelopathy on exam should raise concern for what complication associated with OI?

Basilar invagination

What upper extremity fracture is pathognomonic for OI?

Olecranon apophyseal avulsion fracture

What lower extremity deformity associated with OI can lead to a Trendelenburg gait?

Coxa Vara

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Jose M. Ramirez
    • 1
  1. 1.Department of Orthopaedic SurgeryAlpert Medical School of Brown UniversityProvidenceUSA

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