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Melanoma pp 605-621 | Cite as

Management of Non-melanoma Skin Cancers: Rare Subtypes

  • Michael Saco
  • Neil Alan Fenske
  • Basil Cherpelis
Chapter

Abstract

Several rare types of non-melanoma skin cancer exist that each present unique challenges in terms of diagnosis and management. Merkel cell carcinoma is a neuroendocrine skin cancer that is typically found on the head and neck region of older Caucasian males. It typically presents as an asymptomatic, rapidly growing red-violet nodule. Due to its aggressive nature, surgical excision with wide margins or Mohs surgery, often with adjuvant radiation, is recommended therapy. Pembrolizumab is a newer therapy for advanced Merkel cell carcinoma that has shown great promise. Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive and rarely metastatic sarcoma with extensive subclinical spread, necessitating large excision margins or Mohs surgery for treatment. Imatinib has been shown to be effective in a specific subset of advanced DFSP lesions. Atypical fibroxanthoma (AFX) is an intermediate-grade, superficial fibrohistiocytic neoplasm that typically presents on the head and neck of elderly Caucasian males. Newer guidelines have separated AFX and undifferentiated pleomorphic sarcoma (UPS) into two separate lesions. Treatment for AFX is primarily surgical via wide local excision or Mohs micrographic surgery. Sebaceous carcinoma is a rare and aggressive malignancy that is separated into periorbital and extraocular subtypes. Sebaceous carcinoma is primarily treated with wide local excision or Mohs surgery. Sentinel lymph node biopsy is recommended for periorbital sebaceous carcinoma, but not typically for extraocular sebaceous carcinoma. Dermatologists play a critical role in the diagnosis and treatment of all of these tumors, often in conjunction with a multispecialty team for comprehensive management.

Keywords

Merkel cell carcinoma Dermatofibrosarcoma protuberans Atypical fibroxanthoma Undifferentiated pleomorphic sarcoma Sebaceous carcinoma 

References

  1. 1.
    Toker C. Trabecular carcinoma of the skin. Arch Dermatol. 1972;105(1):107–10.CrossRefPubMedGoogle Scholar
  2. 2.
    Youlden DR, Soyer HP, Youl PH, Fritschi L, Baade PD. Incidence and survival for Merkel cell carcinoma in Queensland, Australia, 1993–2010. JAMA Dermatol. 2014;150(8):864–72.  https://doi.org/10.1001/jamadermatol.2014.124.CrossRefPubMedGoogle Scholar
  3. 3.
    Fitzgerald TL, Dennis S, Kachare SD, Vohra NA, Wong JH, Zervos EE. Dramatic increase in the incidence and mortality from Merkel cell carcinoma in the United States. Am Surg. 2015;81(8):802–6.PubMedGoogle Scholar
  4. 4.
    Brummer GC, Bowen AR, Bowen GM. Merkel cell carcinoma: current issues regarding diagnosis, management, and emerging treatment strategies. Am J Clin Dermatol. 2016;17(1):49–62.  https://doi.org/10.1007/s40257-015-0163-3.CrossRefPubMedGoogle Scholar
  5. 5.
    Ma JE, Brewer JD. Merkel cell carcinoma in immunosuppressed patients. Cancers. 2014;6(3):1328–50.  https://doi.org/10.3390/cancers6031328.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas PF, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol. 2008;58(3):375–81.  https://doi.org/10.1016/j.jaad.2007.11.020.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Harms KL, Healy MA, Nghiem P, Sober AJ, Johnson TM, Bichakjian CK, et al. Analysis of prognostic factors from 9387 Merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system. Ann Surg Oncol. 2016;23(11):3564–71.  https://doi.org/10.1245/s10434-016-5266-4.CrossRefPubMedGoogle Scholar
  8. 8.
    Lanoy E, Costagliola D, Engels EA. Skin cancers associated with HIV infection and solid-organ transplantation among elderly adults. Int J Cancer. 2010;126(7):1724–31.  https://doi.org/10.1002/ijc.24931.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Lanoy E, Dores GM, Madeleine MM, Toro JR, Fraumeni JF Jr, Engels EA. Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS. 2009;23(3):385–93.  https://doi.org/10.1097/QAD.0b013e3283213046.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Brewer JD, Shanafelt TD, Call TG, Cerhan JR, Roenigk RK, Weaver AL, et al. Increased incidence of malignant melanoma and other rare cutaneous cancers in the setting of chronic lymphocytic leukemia. Int J Dermatol. 2015;54(8):e287–93.  https://doi.org/10.1111/ijd.12564.CrossRefPubMedGoogle Scholar
  11. 11.
    Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW. Merkel cell carcinoma and HIV infection. Lancet. 2002;359(9305):497–8.  https://doi.org/10.1016/s0140-6736(02)07668-7.CrossRefPubMedGoogle Scholar
  12. 12.
    Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science (New York, NY). 2008;319(5866):1096–100.  https://doi.org/10.1126/science.1152586.CrossRefGoogle Scholar
  13. 13.
    Kassem A, Schopflin A, Diaz C, Weyers W, Stickeler E, Werner M, et al. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008;68(13):5009–13.  https://doi.org/10.1158/0008-5472.can-08-0949.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Foulongne V, Dereure O, Kluger N, Moles JP, Guillot B, Segondy M. Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases. Br J Dermatol. 2010;162(1):59–63.  https://doi.org/10.1111/j.1365-2133.2009.09381.x.CrossRefPubMedGoogle Scholar
  15. 15.
    Tolstov YL, Pastrana DV, Feng H, Becker JC, Jenkins FJ, Moschos S, et al. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer. 2009;125(6):1250–6.  https://doi.org/10.1002/ijc.24509.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Ratner D, Nelson BR, Brown MD, Johnson TM. Merkel cell carcinoma. J Am Acad Dermatol. 1993;29(2 Pt 1):143–56.CrossRefPubMedGoogle Scholar
  17. 17.
    Skelton HG, Smith KJ, Hitchcock CL, McCarthy WF, Lupton GP, Graham JH. Merkel cell carcinoma: analysis of clinical, histologic, and immunohistologic features of 132 cases with relation to survival. J Am Acad Dermatol. 1997;37(5 Pt 1):734–9.CrossRefPubMedGoogle Scholar
  18. 18.
    Mott RT, Smoller BR, Morgan MB. Merkel cell carcinoma: a clinicopathologic study with prognostic implications. J Cutan Pathol. 2004;31(3):217–23.CrossRefPubMedGoogle Scholar
  19. 19.
    Andea AA, Coit DG, Amin B, Busam KJ. Merkel cell carcinoma: histologic features and prognosis. Cancer. 2008;113(9):2549–58.  https://doi.org/10.1002/cncr.23874.CrossRefPubMedGoogle Scholar
  20. 20.
    Chan JK, Suster S, Wenig BM, Tsang WY, Chan JB, Lau AL. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol. 1997;21(2):226–34.CrossRefPubMedGoogle Scholar
  21. 21.
    Byrd-Gloster AL, Khoor A, Glass LF, Messina JL, Whitsett JA, Livingston SK, et al. Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor. Hum Pathol. 2000;31(1):58–62.CrossRefPubMedGoogle Scholar
  22. 22.
    National Comprehensive Cancer Network. Merkel Cell Carcinoma (Version 1.2017). https://www.nccn.org/professionals/physician_gls/pdf/mcc.pdf. Accessed 26 Nov 2016.
  23. 23.
    Tarantola TI, Vallow LA, Halyard MY, Weenig RH, Warschaw KE, Grotz TE, et al. Prognostic factors in Merkel cell carcinoma: analysis of 240 cases. J Am Acad Dermatol. 2013;68(3):425–32.  https://doi.org/10.1016/j.jaad.2012.09.036.CrossRefPubMedGoogle Scholar
  24. 24.
    Iyer JG, Storer BE, Paulson KG, Lemos B, Phillips JL, Bichakjian CK, et al. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma. J Am Acad Dermatol. 2014;70(4):637–43.  https://doi.org/10.1016/j.jaad.2013.11.031.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Gupta SG, Wang LC, Penas PF, Gellenthin M, Lee SJ, Nghiem P. Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: the Dana-Farber experience and meta-analysis of the literature. Arch Dermatol. 2006;142(6):685–90.  https://doi.org/10.1001/archderm.142.6.685.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Gunaratne DA, Howle JR, Veness MJ. Sentinel lymph node biopsy in Merkel cell carcinoma: a 15-year institutional experience and statistical analysis of 721 reported cases. Br J Dermatol. 2016;174(2):273–81.  https://doi.org/10.1111/bjd.14240.CrossRefPubMedGoogle Scholar
  27. 27.
    Lipsett PA, Ruan JH, Reeves M. A merkel cell carcinoma treatment algorithm. Arch Surg. 2009;144(6):582–5.  https://doi.org/10.1001/archsurg.2009.91.CrossRefGoogle Scholar
  28. 28.
    Ramahi E, Choi J, Fuller CD, Eng TY. Merkel cell carcinoma. Am J Clin Oncol. 2013;36(3):299–309.  https://doi.org/10.1097/COC.0b013e318210f83c.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Kline L, Coldiron B. Mohs micrographic surgery for the treatment of Merkel cell carcinoma. Dermatol Surg. 2016;42(8):945–51.  https://doi.org/10.1097/dss.0000000000000801.CrossRefPubMedGoogle Scholar
  30. 30.
    Strom T, Carr M, Zager JS, Naghavi A, Smith FO, Cruse CW, et al. Radiation therapy is associated with improved outcomes in Merkel cell carcinoma. Ann Surg Oncol. 2016;23(11):3572–8.  https://doi.org/10.1245/s10434-016-5293-1.CrossRefPubMedGoogle Scholar
  31. 31.
    Kim JA, Choi AH. Effect of radiation therapy on survival in patients with resected Merkel cell carcinoma: a propensity score surveillance, epidemiology, and end results database analysis. JAMA Dermatol. 2013;149(7):831–8.  https://doi.org/10.1001/jamadermatol.2013.409.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Frohm ML, Griffith KA, Harms KL, Hayman JA, Fullen DR, Nelson CC, et al. Recurrence and survival in patients with Merkel cell carcinoma undergoing surgery without adjuvant radiation therapy to the primary site. JAMA Dermatol. 2016;152(9):1001–7.  https://doi.org/10.1001/jamadermatol.2016.1428.CrossRefPubMedGoogle Scholar
  33. 33.
    Bhatia S, Storer BE, Iyer JG, Moshiri A, Parvathaneni U, Byrd D, et al. Adjuvant radiation therapy and chemotherapy in Merkel cell carcinoma: survival analyses of 6908 cases from the National Cancer Data Base. J Natl Cancer Inst. 2016;108(9):djw042.  https://doi.org/10.1093/jnci/djw042.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Asgari MM, Sokil MM, Warton EM, Iyer J, Paulson KG, Nghiem P. Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma. JAMA Dermatol. 2014;150(7):716–23.  https://doi.org/10.1001/jamadermatol.2013.8116.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, et al. PD-1 blockade with Pembrolizumab in advanced Merkel-cell carcinoma. N Engl J Med. 2016;374(26):2542–52.  https://doi.org/10.1056/NEJMoa1603702.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    McPeak CJ, Cruz T, Nicastri AD. Dermatofibrosarcoma protuberans: an analysis of 86 cases--five with metastasis. Ann Surg. 1967;166(5):803–16.CrossRefPubMedPubMedCentralGoogle Scholar
  37. 37.
    Gloster HM Jr. Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996;35(3 Pt 1):355–74. quiz 75-6CrossRefPubMedGoogle Scholar
  38. 38.
    National Comprehensive Cancer Network. Dermatofibrosarcoma Protuberans (Version 1.2017). https://www.nccn.org/professionals/physician_gls/pdf/dfsp.pdf. Accessed 26 Nov 2016.
  39. 39.
    Criscione VD, Weinstock MA. Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002. J Am Acad Dermatol. 2007;56(6):968–73.  https://doi.org/10.1016/j.jaad.2006.09.006.CrossRefPubMedGoogle Scholar
  40. 40.
    Kreicher KL, Kurlander DE, Gittleman HR, Barnholtz-Sloan JS, Bordeaux JS. Incidence and survival of primary Dermatofibrosarcoma protuberans in the United States. Dermatol Surg. 2016;42(Suppl 1):S24–31.  https://doi.org/10.1097/dss.0000000000000300.CrossRefPubMedGoogle Scholar
  41. 41.
    Criscito MC, Martires KJ, Stein JA. Prognostic factors, treatment, and survival in Dermatofibrosarcoma protuberans. JAMA Dermatol. 2016;152(12):1365–71.  https://doi.org/10.1001/jamadermatol.2016.1886.CrossRefPubMedGoogle Scholar
  42. 42.
    Bogucki B, Neuhaus I, Hurst EA. Dermatofibrosarcoma protuberans: a review of the literature. Dermatol Surg. 2012;38(4):537–51.  https://doi.org/10.1111/j.1524-4725.2011.02292.x.CrossRefPubMedGoogle Scholar
  43. 43.
    Liang CA, Jambusaria-Pahlajani A, Karia PS, Elenitsas R, Zhang PD, Schmults CD. A systematic review of outcome data for dermatofibrosarcoma protuberans with and without fibrosarcomatous change. J Am Acad Dermatol. 2014;71(4):781–6.  https://doi.org/10.1016/j.jaad.2014.03.018.CrossRefPubMedGoogle Scholar
  44. 44.
    Llombart B, Serra-Guillén C, Monteagudo C, López Guerrero JA, Sanmartín O. Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management. Semin Diagn Pathol. 2013;30(1):13–28.  https://doi.org/10.1053/j.semdp.2012.01.002.CrossRefPubMedGoogle Scholar
  45. 45.
    Cribier B, Noacco G, Peltre B, Grosshans E. Stromelysin 3 expression: a useful marker for the differential diagnosis dermatofibroma versus dermatofibrosarcoma protuberans. J Am Acad Dermatol. 2002;46(3):408–13.  https://doi.org/10.1067/mjd.2002.119656.CrossRefPubMedGoogle Scholar
  46. 46.
    Llombart B, Monteagudo C, Sanmartín O, López-Guerrero JA, Serra-Guillén C, Poveda A, et al. Dermatofibrosarcoma protuberans: a clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors. J Am Acad Dermatol. 2011;65(3):564–75.  https://doi.org/10.1016/j.jaad.2010.06.020.CrossRefPubMedGoogle Scholar
  47. 47.
    Ratner D, Thomas CO, Johnson TM, Sondak VK, Hamilton TA, Nelson BR, et al. Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans. Results of a multiinstitutional series with an analysis of the extent of microscopic spread. J Am Acad Dermatol. 1997;37(4):600–13.CrossRefPubMedGoogle Scholar
  48. 48.
    Lowe GC, Onajin O, Baum CL, Otley CC, Arpey CJ, Roenigk RK, et al. A comparison of Mohs micrographic surgery and wide local excision for treatment of dermatofibrosarcoma protuberans with long-term follow-up: the Mayo clinic experience. Dermatol Surg. 2017;43(1):98–106.  https://doi.org/10.1097/dss.0000000000000910.CrossRefPubMedGoogle Scholar
  49. 49.
    Foroozan M, Sei JF, Amini M, Beauchet A, Saiag P. Efficacy of Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: systematic review. Arch Dermatol. 2012;148(9):1055–63.  https://doi.org/10.1001/archdermatol.2012.1440.CrossRefPubMedGoogle Scholar
  50. 50.
    Pallure V, Dupin N, Guillot B. Surgical treatment of Darier-Ferrand dermatofibrosarcoma: a systematic review. Dermatol Surg. 2013;39(10):1417–33.  https://doi.org/10.1111/dsu.12299.CrossRefPubMedGoogle Scholar
  51. 51.
    McArthur GA, Demetri GD, van Oosterom A, Heinrich MC, Debiec-Rychter M, Corless CL, et al. Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225. J Clin Oncol. 2005;23(4):866–73.  https://doi.org/10.1200/jco.2005.07.088.CrossRefPubMedGoogle Scholar
  52. 52.
    Rutkowski P, Van Glabbeke M, Rankin CJ, Ruka W, Rubin BP, Debiec-Rychter M, et al. Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials. J Clin Oncol. 2010;28(10):1772–9.  https://doi.org/10.1200/jco.2009.25.7899.CrossRefPubMedPubMedCentralGoogle Scholar
  53. 53.
    National Comprehensive Cancer Network. Soft Tissue Sarcoma (Version 2.2017). https://www.nccn.org/professionals/physician_gls/pdf/sarcoma.pdf. Accessed 6 Mar 2017.
  54. 54.
    Iorizzo LJ 3rd, Brown MD. Atypical fibroxanthoma: a review of the literature. Dermatol Surg. 2011;37(2):146–57.  https://doi.org/10.1111/j.1524-4725.2010.01843.x.CrossRefPubMedGoogle Scholar
  55. 55.
    Goldblum JR. An approach to pleomorphic sarcomas: can we subclassify, and does it matter? Mod Pathol. 2014;27(Suppl 1):S39–46.  https://doi.org/10.1038/modpathol.2013.174.CrossRefPubMedGoogle Scholar
  56. 56.
    Rouhani P, Fletcher CD, Devesa SS, Toro JR. Cutaneous soft tissue sarcoma incidence patterns in the U.S.: an analysis of 12,114 cases. Cancer. 2008;113(3):616–27.  https://doi.org/10.1002/cncr.23571.CrossRefPubMedGoogle Scholar
  57. 57.
    Fretzin DF, Helwig EB. Atypical fibroxanthoma of the skin. A clinicopathologic study of 140 cases. Cancer. 1973;31(6):1541–52.CrossRefPubMedGoogle Scholar
  58. 58.
    Limmer BL, Clark DP. Cutaneous micrographic surgery for atypical fibroxanthoma. Dermatol Surg. 1997;23(7):553–7. discussion 7–8CrossRefPubMedGoogle Scholar
  59. 59.
    Huether MJ, Zitelli JA, Brodland DG. Mohs micrographic surgery for the treatment of spindle cell tumors of the skin. J Am Acad Dermatol. 2001;44(4):656–9.  https://doi.org/10.1067/mjd.2001.112381.CrossRefPubMedGoogle Scholar
  60. 60.
    Colgan MB, Brewer JD, Weaver AL, Roenigk RK, Otley CC. Atypical fibroxanthoma in the setting of chronic lymphocytic Leukemia and other non-Hodgkin lymphomas. Dermatol Surg. 2011;37(5):671–6.  https://doi.org/10.1111/j.1524-4725.2011.01947.x.CrossRefPubMedGoogle Scholar
  61. 61.
    Hollmig ST, Sachdev R, Cockerell CJ, Posten W, Chiang M, Kim J. Spindle cell neoplasms encountered in dermatologic surgery: a review. Dermatol Surg. 2012;38(6):825–50.  https://doi.org/10.1111/j.1524-4725.2012.02296.x.CrossRefPubMedGoogle Scholar
  62. 62.
    Henderson MT, Hollmig ST. Malignant fibrous histiocytoma: changing perceptions and management challenges. J Am Acad Dermatol. 2012;67(6):15–41.  https://doi.org/10.1016/j.jaad.2012.04.013.CrossRefGoogle Scholar
  63. 63.
    Shin J, Vincent JG, Cuda JD, Xu H, Kang S, Kim J, et al. Sox10 is expressed in primary melanocytic neoplasms of various histologies but not in fibrohistiocytic proliferations and histiocytoses. J Am Acad Dermatol. 2012;67(4):717–26.  https://doi.org/10.1016/j.jaad.2011.12.035.CrossRefPubMedGoogle Scholar
  64. 64.
    Hanlon A, Stasko T, Christiansen D, Cyrus N, Galan A. LN2, CD10, and Ezrin do not distinguish between atypical fibroxanthoma and undifferentiated pleomorphic sarcoma or predict clinical outcome. Dermatol Surg. 2017;43(3):431–6.  https://doi.org/10.1097/dss.0000000000001000.CrossRefPubMedGoogle Scholar
  65. 65.
    Davis JL, Randle HW, Zalla MJ, Roenigk RK, Brodland DG. A comparison of Mohs micrographic surgery and wide excision for the treatment of atypical fibroxanthoma. Dermatol Surg. 1997;23(2):105–10.CrossRefPubMedGoogle Scholar
  66. 66.
    Ang GC, Roenigk RK, Otley CC, Phillips KP, Weaver AL. More than 2 decades of treating atypical fibroxanthoma at Mayo Clinic: what have we learned from 91 patients? Dermatol Surg. 2009;35(5):765–72.  https://doi.org/10.1111/j.1524-4725.2009.01126.x.CrossRefPubMedGoogle Scholar
  67. 67.
    Brown MD, Swanson NA. Treatment of malignant fibrous histiocytoma and atypical fibrous xanthomas with micrographic surgery. J Dermatol Surg Oncol. 1989;15(12):1287–92.CrossRefPubMedGoogle Scholar
  68. 68.
    Seavolt M, McCall M. Atypical fibroxanthoma: review of the literature and summary of 13 patients treated with Mohs micrographic surgery. Dermatol Surg. 2006;32(3):435–41.; discussion 9–41.  https://doi.org/10.1111/j.1524-4725.2006.32087.x.CrossRefPubMedGoogle Scholar
  69. 69.
    Zalla MJ, Randle HW, Brodland DG, Davis JL, Roenigk RK. Mohs surgery vs wide excision for atypical fibroxanthoma: follow-up. Dermatol Surg. 1997;23(12):1223–4.CrossRefPubMedGoogle Scholar
  70. 70.
    Hollmig ST, Kirkland EB, Henderson MT, Tang JY, Gladstone HB. The evolving conception and management challenges of malignant fibrous histiocytoma. Dermatol Surg. 2012;38(12):1922–9.  https://doi.org/10.1111/j.1524-4725.2012.02538.x.CrossRefPubMedGoogle Scholar
  71. 71.
    Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM. Sebaceous carcinoma. J Am Acad Dermatol. 1995;33(1):1–15. quiz 6–8CrossRefPubMedGoogle Scholar
  72. 72.
    Kyllo RL, Brady KL, Hurst EA. Sebaceous carcinoma: review of the literature. Dermatol Surg. 2015;41(1):1–15.  https://doi.org/10.1097/dss.0000000000000152.CrossRefPubMedGoogle Scholar
  73. 73.
    Tripathi R, Chen Z, Li L, Bordeaux JS. Incidence and survival of sebaceous carcinoma in the United States. J Am Acad Dermatol. 2016;75(6):1210–5.  https://doi.org/10.1016/j.jaad.2016.07.046.CrossRefPubMedGoogle Scholar
  74. 74.
    Tryggvason G, Bayon R, Pagedar NA. Epidemiology of sebaceous carcinoma of the head and neck: implications for lymph node management. Head Neck. 2012;34(12):1765–8.  https://doi.org/10.1002/hed.22009.CrossRefPubMedGoogle Scholar
  75. 75.
    Chang AY, Miller CJ, Elenitsas R, Newman JG, Sobanko JF. Management considerations in extraocular sebaceous carcinoma. Dermatol Surg. 2016;42(Suppl 1):S57–65.  https://doi.org/10.1097/dss.0000000000000575.CrossRefPubMedGoogle Scholar
  76. 76.
    Eisen DB, Michael DJ. Sebaceous lesions and their associated syndromes: part II. J Am Acad Dermatol. 2009;61(4):563–78.; quiz 79–80.  https://doi.org/10.1016/j.jaad.2009.04.059.CrossRefPubMedGoogle Scholar
  77. 77.
    Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer. 2009;115(1):158–65.  https://doi.org/10.1002/cncr.23952.CrossRefPubMedGoogle Scholar
  78. 78.
    Hou JL, Killian JM, Baum CL, Otley CC, Roenigk RK, Arpey CJ, et al. Characteristics of sebaceous carcinoma and early outcomes of treatment using Mohs micrographic surgery versus wide local excision: an update of the Mayo Clinic experience over the past 2 decades. Dermatol Surg. 2014;40(3):241–6.  https://doi.org/10.1111/dsu.124.CrossRefPubMedGoogle Scholar
  79. 79.
    Day A, Abramson AK, Patel M, Warren RB, Menter MA. The spectrum of oculocutaneous disease: Part II. Neoplastic and drug-related causes of oculocutaneous disease. J Am Acad Dermatol. 2014;70(5):821.e1–19.  https://doi.org/10.1016/j.jaad.2013.12.019.CrossRefGoogle Scholar
  80. 80.
    Thosani MK, Marghoob A, Chen C-SJ. Current progress of immunostains in Mohs micrographic surgery: a review. Dermatol Surg. 2008;34(12):1621–36.PubMedGoogle Scholar
  81. 81.
    Spencer JM, Nossa R, Tse DT, Sequeira M. Sebaceous carcinoma of the eyelid treated with Mohs micrographic surgery. J Am Acad Dermatol. 2001;44(6):1004–9.  https://doi.org/10.1067/mjd.2001.113692.CrossRefPubMedGoogle Scholar
  82. 82.
    Yount AB, Bylund D, Pratt SG, Greenway HT. Mohs micrographic excision of sebaceous carcinoma of the eyelids. Dermatol Surg. 1994;20(8):523–9.  https://doi.org/10.1111/j.1524-4725.1994.tb00137.x.CrossRefGoogle Scholar
  83. 83.
    Snow SN, Larson PO, Lucarelli MJ, Lemke BN, Madjar DD. Sebaceous carcinoma of the eyelids treated by mohs micrographic surgery: report of nine cases with review of the literature. Dermatol Surg. 2002;28(7):623–31.PubMedGoogle Scholar
  84. 84.
    Brady KL, Hurst EA. Sebaceous carcinoma treated with mohs micrographic surgery. Dermatol Surg. 2017;43(2):281–6.  https://doi.org/10.1097/dss.0000000000000943.CrossRefPubMedGoogle Scholar
  85. 85.
    Eisen DB, Michael DJ. Sebaceous lesions and their associated syndromes: part I. J Am Acad Dermatol. 2009;61(4):549–60.; quiz 61–2.  https://doi.org/10.1016/j.jaad.2009.04.058.CrossRefPubMedGoogle Scholar
  86. 86.
    Everett JN, Raymond VM, Dandapani M, et al. Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm. JAMA Dermatol. 2014;150(12):1315–21.  https://doi.org/10.1001/jamadermatol.2014.1217.CrossRefPubMedPubMedCentralGoogle Scholar
  87. 87.
    Lee BA, Yu L, Ma L, Lind AC, Lu D. Sebaceous neoplasms with mismatch repair protein expressions and the frequency of co-existing visceral tumors. J Am Acad Dermatol. 2012;67(6):1228–34.  https://doi.org/10.1016/j.jaad.2012.03.020.CrossRefPubMedGoogle Scholar
  88. 88.
    Ho VH, Ross MI, Prieto VG, Khaleeq A, Kim S, Esmaeli B. Sentinel lymph node biopsy for sebaceous cell carcinoma and melanoma of the ocular adnexa. Arch Otolaryngol Head Neck Surg. 2007;1(8):820–6.  https://doi.org/10.1001/archotol.133.8.820.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Michael Saco
    • 1
  • Neil Alan Fenske
    • 1
  • Basil Cherpelis
    • 1
  1. 1.Department of Dermatology and Cutaneous SurgeryMorsani College of Medicine, University of South FloridaTampaUSA

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