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Melanoma pp 549-565 | Cite as

Adoptive Cell Therapy for Melanoma

  • Jane Mills
  • Phillip Darcy
  • David E. Gyorki
Chapter

Abstract

Melanoma is a highly immunogenic cancer, and along with the combination of poor clinical outcomes and treatments with limited efficacy, these attributes have made metastatic melanoma an ideal platform to study immune-based therapies. Adoptive cell therapy (ACT) is as a highly effective personalized cancer treatment, utilizing the natural effector functions of T cells targeting tumor antigens.

This chapter will concentrate on the development and efficacy of ACT in melanoma. The chapter reviews the role of the immune system in melanoma, the identification and targeting of specific tumor antigens, and the mechanisms by which tumor cells may evade detection and eradication. The utility of tumor infiltrating lymphocyte (TIL) based ACT is described, outlining its development, success, modifications, and limitations. Finally the chapter describes T cell engineering and the development and use of chimeric antigen receptors (CAR) as an alternative strategy in this exciting and rapidly expanding area of immuno-oncology.

Keywords

Melanoma Adoptive cell therapy Tumor infiltrating lymphocyte Immunotherapy Chimeric antigen receptor 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Cancer SurgeryPeter MacCallum Cancer CentreMelbourneAustralia
  2. 2.Research DivisionPeter MacCallum Cancer CentreMelbourneAustralia
  3. 3.Department of SurgeryUniversity of MelbourneParkvilleAustralia

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