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Mode of Action on Trypanosoma and Leishmania spp.

  • María E. Lombardo
  • Alcira Batlle
Chapter

Abstract

In this chapter, the most common molecular targets and mechanisms of action of anti-trypanosomatid drugs are described: biosynthesis of sterols, trypanothione pathway, purine salvage pathway, cysteine proteinases, trans-sialidase, metallocarboxypeptidases, tubulin, calcium homeostasis and pyrophosphate metabolism, heme uptake and degradation, glycolytic pathway, DNA interaction, oxidative stress and apoptosis. Interaction of the sesquiterpene lactones with hemin, the induction of oxidative stress, the inhibition of enzymes as cruzipain and trypanothione reductase, the apoptosis induction and the ability of this type of compounds to inhibit sterol biosynthesis will be also discussed.

Keywords

Anti-trypanosomatid drugs Drug targets Sterol biosynthesis Trypanothione pathway Proteinases Trans-sialidase Tubulin Heme Oxidative stress Apoptosis 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química BiológicaBuenos AiresArgentina
  2. 2.CONICET – Universidad de Buenos Aires, Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP)Buenos AiresArgentina

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