Thrombosis and Embolism

  • Reinhard B. Dettmeyer


Pulmonary embolism following deep vein thrombosis is one of the most common natural causes of death. Occasionally, the question of age of the thrombosis and thromboembolism arises, meaning that possible thrombus organization in the vessel wall needs to be investigated. However, other embolisms also play a role in forensic medicine: fat and bone marrow embolisms following previous trauma, such as decollement, air embolism following the opening of neck veins by a deep knife incision, embolisms in i.v. drug abuse with foreign-body pulmonary granulomas, and the rare amniotic fluid embolism. Iatrogenic embolisms, such as bone or cement embolism during total hip endoprosthesis or the embolic spread of rinsing fluid during prostate surgery, are seldom. Extremely rare embolisms include, e.g., silicone embolism syndrome (SES), projectile embolism following a bullet wound, and tumor embolism. Most of the abovementioned embolisms can only be detected microscopically.


  1. Adebahr G (1952) Luftembolie im großen Kreislauf (Herz und Gehirn). (Sonderabdruck) Zbl Allg Path Anat 89:216–222Google Scholar
  2. Adebahr G (1953) Studien zum anatomischen Nachweis der Luftembolie unter besonderer Berücksichtigung der morphologischen Verhältnisse des Herzblutes. Virchows Arch 323:155–173CrossRefGoogle Scholar
  3. Adebahr G (1954) Beobachtungen und experimentelle Untersuchungen zum anatomischen Nachweis der Luftembolie. (Sonderabdruck) Zbl All Path Anat 92:53–58Google Scholar
  4. Adebahr G (1960) Anatomischer Nachweis der Luftembolie im Herzblut. Zbl Allg Path Anat 101:347–352Google Scholar
  5. Adebahr G (1979) Die Bedeutung von Sperrarterien für die Entstehung von Blutungen und kleinen hämorrhagischen Infarkten in der Lunge des Menschen bei Fettembolie. Z Rechtsmed 83:291–302PubMedCrossRefGoogle Scholar
  6. Adebahr G, Kupffer A (1967) Morphologischer Nachweis der Luftembolie im Herzblut. Abwandlung des Befundes in der Barbituratvergiftung beim Kaninchen. Dtsch Z gerichtl Med 61:1–12Google Scholar
  7. Adebahr G, Weiler G, Risse M (1984) Die Bedeutung der mikroskopischen Untersuchung der mittleren und kleinen Äste der Arteria pulmonalis für die Diagnose der Luftembolie. Z Rechtsmed 92:127–135PubMedCrossRefGoogle Scholar
  8. Aguilera LG, Fernandez C, Plaza A, Gracia J, Gomar C (2002) Fatal amniotic fluid embolism diagnosed histologically. Acta Anaesthesiol Scand 46:334–337PubMedCrossRefGoogle Scholar
  9. Althoff H (1967) Fremdkörperembolie in das Gehirn nach Betriebsunfall. Monatsschr Unfallheilkde 70:124Google Scholar
  10. Amberg R, Kernbach-Wighton G, Madea B (2015) Palacos® embolization following vertebroplasty. Rechtsmedizin 25:556–560CrossRefGoogle Scholar
  11. Attwood HD, Delprado WJ (1988) Amniotic fluid embolism: fatal case confirmed at autopsy five weeks after delivery. Pathology 20:381–382PubMedCrossRefGoogle Scholar
  12. Apergis G, Lagzdins M, Soueidan A (2011) Asymptomatic pulmonary cement emboli. Chest 140:8ACrossRefGoogle Scholar
  13. Bajanowski T, West A, Brinkmann B (1998) Proof of fatal air embolism. Int J Legal Med 111:208–211PubMedCrossRefGoogle Scholar
  14. Balažic J, Rott T, Jančigaj T, Popovič M (2003) Amniotic fluid embolism with involvement of the brain, lungs, adrenal glands, and heart. Int J Legal Med 117:165–169PubMedGoogle Scholar
  15. Bollinger SA, Muehlematter K, Thali MJ, Ampanozi G (2011) Correlation of fat embolism severity and subcutaneous fatty tissue crushing and bone fractures. Int J Legal Med 125:453–458CrossRefGoogle Scholar
  16. Bowen DA, Sycamore E (1976) Traumatic air embolism. Med Sci Law 16:56–58PubMedCrossRefGoogle Scholar
  17. Brettel HF, Lutz FU (1973) Die Knorpelembolie als Sonderform vitaler Reaktionen. Z Rechtsmed 72:161PubMedCrossRefGoogle Scholar
  18. Brinkmann B, Borgner M, Bülow M (1976) Die Fettembolie der Lungen als Todesursache – Ätiologie, Pathogenese und Beweisführung. Z Rechtsmed 78:255PubMedCrossRefGoogle Scholar
  19. Bschor F (1963) Fettleber und Fettembolie. Dtsch Med Wschr 88:1112PubMedCrossRefGoogle Scholar
  20. Büchner C (1964) Traumatische Knochenmarksembolie der Lungen. Dtsch Med Wschr 89:1390–1394CrossRefGoogle Scholar
  21. Burke MP, O’Donnell C, Baber Y (2017) Death from pulmonary embolism of cyanoacrylate glue following gastric vein endocopic injection. Forensic Sci Med Pathol 13:82–85PubMedCrossRefGoogle Scholar
  22. Cecchi R, Lazzaro A, Catanese M, Mandarelli G, Ferracuti S (2012) Fatal thromboembolism following physical restraint in a patient with schizophrenia. Int J Legal Med 126:477–482PubMedCrossRefGoogle Scholar
  23. Cha S, Kwon CI, Seon HG, Ko KH, Hong SP, Hwang SG, Park PW, Rim KS (2010) Fatal biliary-systemic air embolism during endoscopic retrograde cholangiopancreatography: a case with multifocal liver abscesses and choledochoduodenostomy. Yonsei Med J 51:287–290PubMedPubMedCentralCrossRefGoogle Scholar
  24. Cheng HM, Chiang KH, Chang PY, Chou YF, Huang HW, Chou AS, Yen PS (2010) Coronary artery air embolism: a potentially fatal complication of CT-guided percutaneous lung biopsy. Br J Radiol 83:e83–e85PubMedCrossRefGoogle Scholar
  25. Christmann W (1969) Nil nocere! Koronare Luftembolie bei internistischem Eingriff (Komplikationen beim Absaugen eines Pneumothorax). Münch Med Wschr 16:938–941Google Scholar
  26. Córdova A, Alfageme I (2014) Foreign-body pulmonary embolism. Chest 145:508ACrossRefGoogle Scholar
  27. Costa AN, Mendes DM, Toufen C, Arrunategui G, Caruso P, de Carvalho CR (2008) Adult respiratory distress syndrome due to fat embolism in the postoperative period following liposuction and fat grafting. J Bras Pneumol 34:622–625PubMedCrossRefGoogle Scholar
  28. Cyr PV, Shuhaibar H, Kay JM (1998) Spontaneous duodenal-caval fistula with embolization of intestinal contents. Hum Pathol 29:1165–1166PubMedCrossRefGoogle Scholar
  29. de la Grandmaison G, Durigon M (2002) Pulmonary embolism. A rare cause of sudden infant death. Am J Forensic Med Pathol 23:257–259PubMedCrossRefGoogle Scholar
  30. Dettmeyer R, Schmidt P, Grellner W, Madea B (1999) “Einschwemmungs-Syndrom” (TUR-Syndrom) mit letalem Verlauf – morphologische und arztrechtliche Aspekte. Rechtsmedizin 10:39–42CrossRefGoogle Scholar
  31. Donohue KG, Saap L, Falanga V (2003) Cholesterol crystal embolization: an atherosclerotic disease with frequent and varied cutaneous manifestations. J Eur Acad Dermatol Venereol 17:504–511PubMedCrossRefGoogle Scholar
  32. Duan Y, Zhang L, Li S, Yang Y, Xing J, Li W, Wang X, Zhou Y (2014) Polyacrylamide hydrogel pulmonary embolism – a fatal consequence of an illegal cosmetic tightening procedure: a case report. Forensic Sci Int 238:e6–e10PubMedCrossRefGoogle Scholar
  33. Duda E, Papilian VV (1962) Exitus post partum durch Fruchtwasserembolie. Zbl Gynäk 84:690Google Scholar
  34. Ely SF, Gill JR (2005) Fatal pulmonary thromboembolism and hereditary thrombophilias. J Forensic Sci 50:411–418PubMedCrossRefGoogle Scholar
  35. Emson HE (1958) Fat embolism studied in 100 patients dying after injury. J Clin Pathol 11:28–35PubMedPubMedCentralCrossRefGoogle Scholar
  36. Falzi G, Henn R, Spann W (1964) Über pulmonale Fettembolien nach Traumen mit verschieden langer Überlebenszeit. Münch Med Wschr 106:978PubMedGoogle Scholar
  37. Fineschi V, Riezzo I, Cantatore S, Pomara C, Turillazzi E, Neri M (2009a) Complement C3a expression and tryptase degranulation as promising histopathological tests for diagnosing fatal amniotic fluid embolism. Virchows Arch 454:283–290PubMedCrossRefGoogle Scholar
  38. Fineschi V, Turillazzi E, Neri M, Pomara C, Riezzo I (2009b) Histological age determination of venous thrombosis: a neglected forensic task in fatal pulmonary thrombo-embolism. Forensic Sci Int 186:22–28PubMedCrossRefGoogle Scholar
  39. Fineschi V, Bafunno V, Bello S, de Stefano F, Margaglione M, Neri M, Riezzo I, Turillazzi E, Bonsignore A, Vecchione G, Ventura F, Grandone E (2012) Fatal pulmonary thromboembolism. A retrospective autopsy study: searching for genetic thrombophilias (Vactor V Leiden (G1691A) and FII (G20210A) gene variants) and dating the thrombus. Forensic Sci Int 214:152–158PubMedGoogle Scholar
  40. Fischbein F (1969) Ischemic retinopathy following amniotic fluid embolization. Am J Ophthalmol 67:351–357PubMedCrossRefGoogle Scholar
  41. Foedisch HJ, Kloos K (1966) Thrombotische Verschlüsse im Stromgebiet der Arteria carotis nach stumpfen Schädelhalstraumen. Hefte Unfallheilkde 88:1Google Scholar
  42. Fracasso T, Varchmin-Schultheiß K (2009) Sudden death due to pulmonary embolism from right atrial myxoma. Int J Legal Med 123:157–159PubMedCrossRefGoogle Scholar
  43. Fracasso T, Karger B, Pfeiffer H, Sauerland C, Schmeling A (2010) Immunohistochemical identification of prevalent right ventricular ischemia causing right heart failure in cases of pulmonary fat embolism. Int J Legal Med 124:537–542PubMedCrossRefGoogle Scholar
  44. Fracasso T, Pfeiffer H, Sauerland C, Schmeling A (2011) Morphological identification of right ventricular failure in cases of fatal pulmonary thromboembolism. Int J Legal Med 125:45–50PubMedCrossRefGoogle Scholar
  45. Fracasso T, Schrag B, Sabatasso S, Lobrinus JA, Schmeling A, Mangin P (2015) Different degrees of ischaemic injury in the right and left ventricle in cases of severe, nonfatal, pulmonary embolism. Int J Legal Med 129:525–529PubMedCrossRefGoogle Scholar
  46. Frick R (1974) Über die histologische Differenzierung von Fettembolie und Silikonembolie nach extrakorporalem Kreislauf mit dem Beuteloxygenator. Beitr Pathol 152:408–417PubMedCrossRefGoogle Scholar
  47. Furuta N, Yaguchi C, Itoh H, Morishima Y, Tamura N, Kato M, Uchida K, Suzuki K, Sugihara Y, Kawabata N, Suzuki T, Sasaki K, Horiuchi K, Kanayama N (2012) Immunohistochemical detection of meconium in the fetal membrane, placenta and umbilical cord. Placenta 33:24–30PubMedCrossRefGoogle Scholar
  48. Garland IW, Thompson WD (1983) Diagnosis of amniotic fluid embolism using an antiserum to human keratin. J Clin Pathol 36:625–627PubMedPubMedCentralCrossRefGoogle Scholar
  49. Gigon JP, Enderlin F, Scheidegger S (1966) Über das Schicksal infundierter Fettemulsionen in der menschlichen Lunge. Schweiz Med Wschr 96:71–75Google Scholar
  50. Gilbert P, Borchard F (1980) Hautembolie der Lunge. Pathologe 1:161–163PubMedGoogle Scholar
  51. Greendyke RM (1964) Fat embolism in fatal automobile accidents. J Forensic Sci 9:201–208PubMedGoogle Scholar
  52. Greiner H (1954) Histologische Befunde bei arterieller Luftembolie. Dtsch Z Gerichtl Med 43:415–523Google Scholar
  53. Hardmeier T (1963) Schwere Fettembolie bei Erfrierungen an beiden unteren Extremitäten. Schweiz Med Wschr 93:465PubMedGoogle Scholar
  54. Harter L (1947) Über Zirkulationsstörungen des Zentralnervensystems bei experimenteller Fett- und Luftembolie. Virchows Arch Path Anat 314:211CrossRefGoogle Scholar
  55. Hausbrandt F (1938) Beitrag zur Frage der kombinierten Luftembolie des kleinen und des großen Kreislaufs nach Abtreibungsversuchen. Dtsch Z Gerichtl Med 30:19Google Scholar
  56. Haynes DM (1956) Cerebral hypoxia from air embolus following attempted abortion. Am J Obstet Gynecol 71:1111–1113PubMedCrossRefGoogle Scholar
  57. Hendry WT (1964) An unusual case of air embolism. Med Sci Law 4:179–181PubMedCrossRefGoogle Scholar
  58. Henn RHE, Spann W (1965) Untersuchungen über die Häufigkeit der cerebralen Fettembolie nach Trauma mit verschieden langer Überlebenszeit. Monatsschr Unfallheilkde 12:513–522Google Scholar
  59. Henßge C, Madea B (1991) Luftembolie bei iatrogener Lungenstichverletzung. In: Schütz H, Kaatsch HJ, Thomsen H (eds) Medizinrecht – psychopathologie – rechtsmedizin. Springer, Heidelberg, pp 393–400CrossRefGoogle Scholar
  60. Hiebert CA, Gregory FJ (1974) Bullet embolism from the head to the heart. JAMA 299:442–443CrossRefGoogle Scholar
  61. Hikiji W, Tamura N, Shigeta A, Kanayama N, Fukunaga T (2013) Fatal amniotic fluid embolism with typical pathohistological, histochemical and clinical features. Forensic Sci Int 226:e16–e19PubMedCrossRefGoogle Scholar
  62. Holczabek W (1968) Das Verhalten der arterio-venösen Anastomosen bei der Lungenfettembolie. Dsch Z Gerichtl Med 62:170Google Scholar
  63. Huber R (1965) Bedeutung der Lungenembolie für gekreuzte Embolien bei offenem Foramen ovale. Schweiz Med Wschr 95:963–969Google Scholar
  64. Hung MJ, Kuo LT, Wang CH, Cherng WJ (2002) Irreversible myocardial damage after coronar air embolism. Angiology 53:213–216PubMedCrossRefGoogle Scholar
  65. Irninger W (1963) Histologische Altersbestimmung von Thrombosen und Embolien. Virch Arch Path Anat 336:220–237CrossRefGoogle Scholar
  66. Iwadate K, Doi M, Tanno K, Katsumura S, Ito H, Sato K, Yonemura I, Ito Y (2003) Right ventricular damage due to pulmonary embolism: examination of the number of infiltrating macrophages. Forensic Sci Int 134:147–153PubMedCrossRefGoogle Scholar
  67. Janík M, Hejna P (2015) Renal cell carcinoma pulmonary embolism: a rare cause of sudden death. Forensic Sci Med Pathol 11:468–471PubMedCrossRefGoogle Scholar
  68. Janssen W (1967) Zur Pathogenese und forensischen Bewertung von Hirnblutungen nach cerebraler Luftembolie. Dtsch Z Gesamte Gerichtl Med 61:62–80PubMedGoogle Scholar
  69. Janssen W (1977) Forensische Histologie. Schmidt-Römhild Verlag, Lübeck, pp 111–150Google Scholar
  70. Jecmenica D, Baralic I, Alempijevic D, Pavlekic S, Kiurski M, Terzic M (2011) Amniotic fluid embolism – apropos two consecutive cases. J Forensic Sci 56:S247–S251. CrossRefPubMedGoogle Scholar
  71. Kaufmann F, Keresztes A (1967) Bericht über die fulminante, tödliche Lungenembolie des Obduktionsmaterials der Jahre 1952 bis 1965. Wiener Klin Wochenschr 79:155–161Google Scholar
  72. Kearney MS (1999) Chronic intrauterine meconium aspiration causes fetal lung infarcts, lung rupture, and meconium embolism. Pediatr Dev Pathol 2:544–551PubMedCrossRefGoogle Scholar
  73. Keil W, Berzlanovich A (2007) Luftembolie. Rechtsmedizinische Aspekte. Rechtsmedizin 17:403–414CrossRefGoogle Scholar
  74. Kim HJ, Seides B, Mulaikal E, Mukherjee V, Eiss B, Patrawalla P (2013) Silicone embolism syndrome (SES): still out there. Chest 144:912ACrossRefGoogle Scholar
  75. Kitulwatte I, Pollanen MS (2009) Electrical injury of the neck and cardiac air embolism: a novel mechanism of death. Forensic Sci Med Pathol 5:32–35PubMedCrossRefGoogle Scholar
  76. Knight B (1966) Fatal pulmonary embolism: factors of forensic interest in 400 cases. Med Sci Law 6:150–154PubMedCrossRefGoogle Scholar
  77. Kobayashi H, Ooi H, Hayakawa H, Arai T, Matsuda Y, Gotoh K, Tarao T (1997) Histological diagnosis of amniotic fluid embolism by monoclonal antibody TKH-2 that recognizes NeuAc alpha 2-6GalNAc epitope. Hum Pathol 28:428–433PubMedCrossRefGoogle Scholar
  78. Köhn K (1952) Kritische Bemerkungen zur histologischen Diagnostik der arteriellen Luftembolie des Gehirns. Frankf Z Pathol 63:360–374PubMedGoogle Scholar
  79. Köhn K (1953) Zum Nachweis der arteriellen Luftembolie des Gehirns. Dtsch Z Gerichtl Med 42:301–307Google Scholar
  80. Konwaler BE (1950) Pulmonary emboli of cotton fibers. Am J Clin Pathol 20:385–389PubMedCrossRefGoogle Scholar
  81. Kössling FK (1963) Zur Pathologie der Fruchtwasserembolie. Geburtsh Frauenheilkde 8:707–720Google Scholar
  82. Krause D, Klein S (1969) Tierexperimentelle Untersuchungen zur postmortalen ophthalmoskopischen Diagnostik der arteriellen Luftembolie. Dtsch Z Gesamte Gerichtl Med 65:22–27PubMedGoogle Scholar
  83. Kunar N, Malviya M, De Meireles M (2014) It should not be here! A strange case of pulmonary cement embolism following balloon kyphoplasty. Chest 143:559ACrossRefGoogle Scholar
  84. Lahl R (1973) Fettembolien nach experimenteller Tetrachlorkohlenstoffintoxikation. Z Gesamte Inn Med 28:367PubMedGoogle Scholar
  85. Lau G (1994) Amniotic fluid embolism as a cause of sudden maternal death. Med Sci Law 34:213–220PubMedCrossRefGoogle Scholar
  86. Lau G (2005) Iatrogenic injury, a forensic perspective. In: Tsokos M (ed) Forensic pathology reviews, vol 3, pp 351–439CrossRefGoogle Scholar
  87. Lau G, Chui PP (1994) Amniotic fluid embolism: a review of 10 fatal cases. Singapore Med J 35:180–183PubMedGoogle Scholar
  88. Leu AJ, Leu HJ (1989) Spezielle Probleme bei der histologischen Altersbestimmung von Thromben und Emboli. Pathologe 10:87–92PubMedGoogle Scholar
  89. Loeschke H (1950) Über zerebrale Luftembolien und ihren Nachweis bei der Sektion. Z Gesamte Inn Med 5:631–633Google Scholar
  90. Lorenz R, Vogelsang HG (1972) Thrombose der Arteria basilaris nach chiropraktischen Maßnahmen an der Halswirbelsäule. Dtsch Med Wschr 123:1389–1399Google Scholar
  91. Lunetta P, Penttilä A (1996) Immunohistochemical identification of syncytiotrophoblastic cells and megakaryocytes in pulmonary vessels in a fatal case of amniotic fluid embolism. Int J Legal Med 108:210–214PubMedCrossRefGoogle Scholar
  92. Maffeis V, Nicolè L, Rago C, Fassina A (2017) Histological criteria for age determination of fatal venous thromboembolism. Int J Leg Med,
  93. Makino Y, Abe H, Yokoyama M, Torimitsu S, Chiba F, Yokota H, Oka T, Iwase H (2015) Mercury embolism of the lung and right ventricle revealed by postmortem computed tomography and X-ray analytic microscopy. Forensic Sci Med Pathol 11:464–467PubMedCrossRefGoogle Scholar
  94. Marcus BJ, Collins KA, Harley RA (2005) Ancillary studies in amniotic fluid embolism: a case report and review of the literature. Am J Forensic Med Pathol 26:92–95PubMedCrossRefGoogle Scholar
  95. Mendoza-Morales RC, Camberos-Nava EV, Luna-Rosas A, Garcés-Ramírez L, de la Cruz F, Garćia-Dolores F (2016) A fatal case of systemic fat embolism resulting from gluteal injections of vitamin E for cosmetic enhancement. Forensic Sci Int 259:e1–e4PubMedCrossRefGoogle Scholar
  96. Mennim P, Coyle CF, Taylor JD (1992) Venous air embolism associated with removal of central venous catheter. Br Med J 305:171–172CrossRefGoogle Scholar
  97. Monticelli F, Meyer HJ, Tutsch-Bauer E (2004) Fatal pulmonary cement embolism following percutaneous vertebroplasty (PVP). Forensic Sci Int 149:35–38CrossRefGoogle Scholar
  98. Nadesam K, Jayalakshimi P (1997) Sudden maternal deaths from amniotic fluid embolism. Ceylon Med J 42:185–189Google Scholar
  99. Nadjem H, Bohnert M, Pollak S (2001) A case of fatal amniotic fluid embolism. Arch Kriminol 207:89–96PubMedGoogle Scholar
  100. Neri M, Riezzo I, Dambrosio M, Poimara C, Turillazzi E, Fineschi V (2010) CD61 and fibrinogen immunohistochemical study to improve the post-mortem diagnosis in a fat embolism syndrome clinically demonstrated by transesophageal echocardiography. Forensic Sci Int 202:e13–e17PubMedCrossRefGoogle Scholar
  101. Nichols GR II, Corey TS, Davis GJ (1990) Nonfracture-associated fatal fat embolism in a case of a child abuse. J Forensic Sci 35:493–499PubMedCrossRefGoogle Scholar
  102. Nishio H, Matsui K, Miyazaki T, Tamura A, Iwata M, Suzuki K (2002) A fatal case of amniotic fluid embolism with elevation of serum mast cell tryptase. Forensic Sci Int 126:53–56PubMedCrossRefGoogle Scholar
  103. Nosaka M, Ishida Y, Kimura A, Kondo T (2009) Time-dependent appearance of intrathrombus neutrophils and macrophages in a stasis-induced deep vein thrombosis model and its application to thrombus age determination. Int J Legal Med 123:235–240PubMedCrossRefGoogle Scholar
  104. Nosaka M, Ishida Y, Kimura A, Kondo T (2010a) Immunohistochemical detection of MMP-2 and MMP-9 in a stasis-induced deep vein thrombosis model and its application to thrombosis age estimation. Int J Legal Med 124:439–444PubMedCrossRefGoogle Scholar
  105. Nosaka M, Ishida Y, Kimura A, Kondo T (2010b) Time-dependent organic changes of intravenous thrombi in stasis-induced deep vein thrombosis model and its application to thrombus age determination. Forensic Sci Int 195:143–147PubMedCrossRefGoogle Scholar
  106. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T (2011) Absence of IFN-ƴ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. J Clin Invest 121:2911–2920PubMedPubMedCentralCrossRefGoogle Scholar
  107. Nosaka M, Ishida Y, Kimura A, Kondo T (2012) Immunohistochemical detection of uPA, tPA, and PAI-1 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation. Int J Legal Med 126:421–425PubMedCrossRefGoogle Scholar
  108. Nosaka M, Ishida Y, Kimura A, Kondo T (2013) Immunohistochemical detection of intrathrombotic macrophage-derived cytokines and its application to thrombus age estimation in murine deep vein thrombosis model. Int J Legal Med 127:937–942PubMedCrossRefGoogle Scholar
  109. Nosaka M, Ishida Y, Kimura A, Hama M, Kawaguchi T, Yamamoto H, Kuminaka Y, Shimada E, Kondo T (2015) Immunohistochemical detection of intrathrombotic IL-6 and its application to thrombus age estimation. Int J Legal Med 129:1021–1025PubMedCrossRefGoogle Scholar
  110. Nosaka M, Ishida Y, Kimura A et al (2017) Immunohistochemical detection of intrathrombotic fibrocytes and its application to thrombus age estimation in murine deep vein thrombosis model. Int J Legal Med 131:179–183PubMedCrossRefGoogle Scholar
  111. Obersteg J (1949) Die Luftembolie bei kriminellem Abort. Dtsch Z Gerichtl Med 39:646–687Google Scholar
  112. Ohi H, Kobayashi H, Terao T (1993) A new histologic diagnosis for amniotic fluid embolism by means of monoclonal antibody TKH-2 that recognizes mucin-type glycoprotein, a component in meconium. Nippon Sanka Fujinka Gakkai Zasshi 44:813–819Google Scholar
  113. Patzelt D, Lignitz E, Keil W, Takatsu A (1978) Zur Problematik der Diagnose Luftembolie an der Leiche. Beitr Ger Med XXXVII:401–405Google Scholar
  114. Penry JK, Cordell AR, Johnston FR, Netsky MG (1960) Cerebral embolism by antifoam A in a bubble oxygenator system. Surgery 47:784–794PubMedGoogle Scholar
  115. Pragst F, Correns A, Priem F, Herre S, Martin H (2007) A sudden death with lung embolism after inadvertent infusion of zinc oxide shake lotion. Forensic Sci Int 170:207–212PubMedCrossRefGoogle Scholar
  116. Preiß G, Brunner P, Tulusan AH (1977) Die pulmonale Silikonembolie. Virchows Arch A Pathol Anat Histopathol 373:55–65CrossRefGoogle Scholar
  117. Rainio J, Penttilä A (2003) Amniotic fluid embolism as cause of death in a car accident – a case report. Forensic Sci Int 137:231–234PubMedCrossRefGoogle Scholar
  118. Rämsch R (1960) Tödliche Fruchtwasserembolie. Zbl Allg Path 101:470–474Google Scholar
  119. Reutter F, Siebenmann R, Wegmann T (1965) Tödliche Lungenembolie bei Verabreichung eines oralen Ovulationshemmers. Schweiz Med Wschr 95:303–305PubMedGoogle Scholar
  120. Ro A, Kageyama N, Tanifuji T, Fukunaga T (2008) Pulmonary thromboembolism: overview and update from medicolegal aspects. Legal Med 10:57–71PubMedCrossRefGoogle Scholar
  121. Röding H, Röse W (1967) Iatrogene Embolien. Dtsch Gesundheitsw 34:1585–1591Google Scholar
  122. Rodriguez MA, Martinez MC, Lopez-Artiquez M, Soria ML, Bernier F, Repetto M (1989) Lung embolism with liquid silicon. J Forensic Sci 34:504–510PubMedCrossRefGoogle Scholar
  123. Rossetti AO, Combrement PC, Bogousslavsky J (2001) Dissections artérielles lors de manipulations cervicales: attention, danger! Schweiz Ärztezeitung 82:495–497CrossRefGoogle Scholar
  124. Rössle R (1944) Über die Luftembolie der Capillaren des großen und kleinen Kreislaufes. Virchows Arch 313:1–27CrossRefGoogle Scholar
  125. Saternus KS (1975) Plötzlicher Tod am Unfallort bei Fußgängern. Kriminalistik 11:498–501Google Scholar
  126. Säker G (1955) Fettembolie bei Verkehrsunfällen. Münch Med Wschr 97:625–628PubMedGoogle Scholar
  127. Schmid A, Tzur A, Leshko L, Krieger BP (2005) Silicone embolism syndrome: a case report, review of the literature, and comparison with fat embolism syndrome. Chest 127:2276–2281PubMedCrossRefGoogle Scholar
  128. Schnabel A, Röhrich J, Schmidt K, Kavert G, Bratzke H (1998) Zur forensischen Beweisführung bei einer Silikonembolie durch Kombination histologischer und toxikologischer Untersuchungsmethoden. Rechtsmedizin 8:147–152CrossRefGoogle Scholar
  129. Schneider V, Klug E (1971) Fettembolie der Lungen nach äußerer Herzmassge. Beitr Ger Med 28:76Google Scholar
  130. Schneider V, Klug E, Phillip W (1983) Die Luftembolie im kleinen Kreislauf – ihr Nachweis an der Leiche. Pathologe 4:97–102PubMedGoogle Scholar
  131. Schoenmackers J (1950) Die markierte arterielle Luftembolie im Kaninchenversuch (Luft-Fettembolie). Virchows Arch 318:234–249PubMedCrossRefGoogle Scholar
  132. Schollmeyer W (1965) Über die Fettembolie des Lungengewebes nach Verbrennung. Forum der Kriminalistik 5:32–34Google Scholar
  133. Schubert W (1952a) Über das Ergebnis einer Reihen- und Gruppenuntersuchung an 150 Leichen zur Prüfung auf arterielle Luftembolien im großen Kreislauf. Virchows Arch 322:472–487PubMedCrossRefGoogle Scholar
  134. Schubert W (1952b) Über einen makroskopischen Nachweis von Luftembolien im Organgewebe durch Fixierung im Unterdruckraum in Formalin im Anschluss an die Sektion. Virchows Arch 322:494–502PubMedCrossRefGoogle Scholar
  135. Schubert W (1954) Weitere Erfahrungen bei Druckstoß von Explosionen und Spontanluftembolien aus der Lunge. Virchows Arch 325:57–69PubMedCrossRefGoogle Scholar
  136. Schubert GE, Reifferscheid P, Flach A (1972) Mikroembolien von Fremdmaterial nach Angiographien und intravenösen Infusionen. Dtsch Med Wschr 97:1745–1748CrossRefGoogle Scholar
  137. Schulz F, Hildebrand E, Graß H (1992) Ein ungewöhnlicher Fall von traumatischer Leberruptur mit Lebergewebsembolie der Lungen. Rechtsmedizin 2:152–155Google Scholar
  138. Schulz F, Tsokos M (2004) Fettleber und Fettembolie. Rechtsmedizin 14:463–466CrossRefGoogle Scholar
  139. Seemann K, Wandel A (1967) Der Taucherunfall mit Überdehnung der Lunge und Luftembolie. Münch Med Wschr 42:2168–2175Google Scholar
  140. Senen D, Atakul D, Erten G, Erdogan B, Lortlar N (2009) Evaluation of the risk of systemic fat mobilization and fat embolus following liposuction with dry and tumescent technique: an experimental study on rats. Aesthetic Plast Surg 33:730–737PubMedCrossRefGoogle Scholar
  141. Shairkh N, Hanssens Y, Kettern MA, Deleu D, Ruiz-Miyares F, Mesraoua B (2008) Cerebral fat embolism as a rare complication of liposuction with abdominoplasty. Rev Neurol 47:277–278Google Scholar
  142. Sigrist T, Markwalder C, Gstrein G (1997) Seltene Form einer cerebralen Embolie nach Karotistrauma. Rechtsmedizin 7:90–94CrossRefGoogle Scholar
  143. Sinicina I, Pankratz H, Bise K, Matevossian E (2010) Forensic aspects of post-mortem histological detection of amniotic fluid embolism. Int J Legal Med 124:55–62PubMedCrossRefGoogle Scholar
  144. Sivanesan S (1976) Bullet embolism to the heart. Med Sci Law 16:59–61PubMedCrossRefGoogle Scholar
  145. Smith WS, Johnston SC, Skalabrin EJ et al (2003) Spinal manipulative therapy is an independent risk factor for vertebral artery dissection. Neurology 60:1424–1428PubMedCrossRefGoogle Scholar
  146. Sowell MW, Lovelady CL, Brogdon BG, Wecht CH (2007) Infant death due to air embolism from peripheral venous infusion. J Forensic Sci 52:183–188PubMedCrossRefGoogle Scholar
  147. Sperr W (1968) Sudanophile Veränderungen am Plexus chorioideus. Dtsch Z Gesamte Gerichtl Med 62:20–25PubMedGoogle Scholar
  148. Steiner I (2007) Pulmonary embolism-temporal changes. Cardiovasc Pathol 16:248–251PubMedCrossRefGoogle Scholar
  149. Stoltenburg-Didinger G, Vogel M (1980) Kleinhirngewebsembolie nach Beckenendlage bei einem Neugeborenen (Falldemonstration). Berliner Gesellsch für Pathologie (e.V.) 189. wissenschaftliche Sitzung – 11.03.1980, Tagungsberichte, p 189Google Scholar
  150. Strange C, Heffner JE, Collins BS, Brown FM, Sahn SA (1987) Pulmonary hemorrhage and air embolism complicating transbronchial biopsy in pulmonary amyloidosis. Chest 92:367–369PubMedCrossRefGoogle Scholar
  151. Strickland S, Pena E, Walker AE (2015) Fatal foreign-body granulomatous pulmonary embolism due to microcrystalline cellulose in a patient receiving total parenteral nutrition: all crystals are not what they seem. Forensic Sci Med Pathol 11:255–261PubMedCrossRefGoogle Scholar
  152. Takada M, Chiba S, Nagai T, Takeshita H, Kanno S, Ikawa T, Sakamoto K, Sagi M, Ichiba K, Mukai T (2015) Inflammatory responses to neutral fat and fatty acids in multiple organs in a rat model of fat embolism syndrome. Forensic Sci Int 254:126–132PubMedCrossRefGoogle Scholar
  153. Turillazzi E, Gambassi R, Gheradi M, Fineschi V (1998) The diagnosis of amniotic fluid embolism: an immunohistochemical study for the quantification of pulmonary mast cell tryptase. Int J Legal Med 111:238–243PubMedCrossRefGoogle Scholar
  154. Türk EE, Tsokos M (2003) Sudden infant death due to pulmonary embolism. Am J Forensic Med Pathol 24:106PubMedCrossRefGoogle Scholar
  155. Türk E, Schulz N, Püschel K (2007) Air embolism during coronary angiography. Rechtsmedizin 17:215–217CrossRefGoogle Scholar
  156. Uekita I, Ijiri I, Nagasaki Y, Haba R, Funamoto Y, Matsunaga T, Jamal M, Wang W, Kumihashi M, Ameno K (2008) Medicolegal investigation of chicken fat clot in forensic cases: immunohistochemical and retrospective studies. Legal Med 10:138–142PubMedCrossRefGoogle Scholar
  157. Vilde F, Arkwright S, Galliot M, Galle P, Labrousse J, Lissac J (1983) Fatal pneumopathy linked to subcutaneous injections of liquid silicone into soft tissue. Ann Pathol 3:307–325PubMedGoogle Scholar
  158. Watanabe S, Terazawa K, Matoba K, Yamada N (2007) An autopsy case of intraoperative death due to pulmonary fat embolism-possibly caused by release of tourniquet after multiple muscle-release and tenotomy of the bilateral lower limbs. Forensic Sci Int 171:73–77PubMedCrossRefGoogle Scholar
  159. Watanabe M, Unuma K, Makino Y, Noritake K, Yamada A, Iwase H, Uemura K (2016) An autopsy case of acute massive hematochezia caused by superior mesenteric vein thrombosis: a first report in forensic medicine. J Forensic Sci 61:271–273PubMedCrossRefGoogle Scholar
  160. Wehner W (1968) Die Fettembolie. VEB Verlag Volk und Gesundheit, BerlinGoogle Scholar
  161. Weiler G (1976) Zur venösen Gasembolie bei diagnostischen und therapeutischen Eingriffen unter besonderer Berücksichtigung des Pneumoperitoneums. Beitr Gerichtl Med 34:9–14PubMedGoogle Scholar
  162. Westcott J (1973) Air embolism complicating percutaneous needle biopsy of the lung. Chest 63:108–110PubMedCrossRefGoogle Scholar
  163. Wild U, Defosse JM, Wappler F, Sakka SG (2013) Luftembolie nach ZVK-Entfernung. Anästhesiol Intensivmed Notfallmed Schmerzther 48:28–31PubMedGoogle Scholar
  164. Wilhelmi F, Hildebrand E (1972) Tödliche Lungenembolie nach Aortenaneurysma-Ruptur in die Vena cava caudalis. Z Rechtsmed 71:246PubMedCrossRefGoogle Scholar
  165. Wilkie TF (1977) Late development of granuloma after liquid silicone injections. Plast Reconstr Surg 60:179–188PubMedCrossRefGoogle Scholar
  166. Wirth E, Staak M (1972) Untersuchungen zur Frage des Auftretens der Fettembolie bei Todesfällen aus traumatischer und nichttraumatischer Ursache. Beitr Ger Med XXIX:98–103Google Scholar
  167. Wojahn H (1970) Klärung einer Abtreibung mit zentraler Luftembolie nach 4 Jahren. Beitr Ger Med XXVII:97–100Google Scholar
  168. Wongprasartsuk S, Finlay M, Perry GJ (2001) Cholesterol emboli to the kidney: an immunoperoxidase study. Pathology 33:157–162PubMedCrossRefGoogle Scholar
  169. Yamamoto K, Yamamoto Y, Watanabe H, Fujimiya T, Okae M, Ukita K (1989) A case of sudden death by decidual cell embolism. Z Rechtsmed 102:415–416PubMedCrossRefGoogle Scholar
  170. Young RL, Derbyshire RC, Cramer OS (1948) Paradoxic embolism. Arch Pathol 46:3–48Google Scholar
  171. Zheng N, Liang M, Zhang HD, Zhu SH, Yang TT, Zhuo L, Wang GF, Liu HX, Liu L (2013) Fatal extensive bone cement embolism: histological findings confirmed by Fourier transform infrared spectroscopy. Forensic Sci Int 229:e23–e25PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Reinhard B. Dettmeyer
    • 1
  1. 1.University Hospital Giessen Institute of Forensic MedicineGiessenGermany

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