Maturational Changes of the Neonatal Brain

  • Gerda Meijler
  • Sylke J. Steggerda


During the foetal and perinatal period, early infancy impressive brain growth and important maturational processes of the brain take place. Because of this ongoing maturation, the neonatal and in particular the preterm brain is very vulnerable to abnormal development and injury. Patterns of perinatal brain injury depend among others on the origin (i.e. traumatic, hypoxic-ischaemic, inflammatory, haemorrhagic, toxic, metabolic) and timing of the injury and on the developmental stage of the brain and thus the postconceptional age of the foetus or newborn at the time of the event(s).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Gerda Meijler
    • 1
  • Sylke J. Steggerda
    • 2
  1. 1.Department of NeonatologyIsala Women and Children’s HospitalZwolleThe Netherlands
  2. 2.Department of NeonatologyLeiden University Medical CenterLeidenThe Netherlands

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