Sinus Node Disease and Cardiac Conduction Disease

  • Patrick A. SchweizerEmail author
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.)


Primary sinus node disease (SND) and cardiac conduction defect (CCD) are frequent clinical entities with significant morbidity and mortality, which are major indications for the implantation of electronic pacemakers. Throughout the previous two decades, pathogenetic mechanisms underlying both disorders have been investigated in detail, and it has been demonstrated that distinct genetic defects and/or predisposing genetic constellations play important roles in a considerable number of cases. Furthermore it has been shown that both entities often are related to a broader clinical spectrum including overlapping arrhythmia syndromes and structural cardiac abnormalities, indicating that specified genetic defects are key to distinct clinical phenotypes. This book chapter summarizes the work, which most profoundly influences the current understanding of primary excitation and conduction disorders of the heart. The novel mechanistic insight into important pathogenetic aspects of these disorders may lay the groundwork for more mechanism-based, individually tailored clinical management of patients with primary SND and CCD in the future.



This work was supported in parts by grants from the Molecular Medicine Partnership Unit, Heidelberg (Senior Career Fellowship to P.A.S.).

Compliance with Ethical Standards

Conflict of Interest

Dr. Schweizer indicates no potential conflicts of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of CardiologyHeidelberg Center for Rhythm Disorders (HCR), Medical University Hospital HeidelbergHeidelbergGermany

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