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Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Personalized Therapeutic Strategies?

  • Daniel Sinnecker
  • Alessandra Moretti
Chapter
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.)

Abstract

Human induced pluripotent stem cells, which can be generated from somatic cells of healthy or diseased subjects, hold a great potential for research in the field of cardiac channelopathies. This review discusses how these cells can be used for disease modelling, as a safety pharmacology platform to assess the proarrhythmic potential of drug candidates, and for developing personalized therapeutic strategies by predicting individual drug responses as well as providing a system for patient-specific cardiac gene expression profiling and in vitro testing of patient-specific therapies.

Notes

Compliance with Ethical Standards

Sources of Funding

The authors have been supported by the German Research Foundation (Mo 2217/1–1, Si 1747/1–1, Research Unit 923), the German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, and the Else Kröner-Fresenius Stiftung.

Conflict of Interest

The authors declared that they have no conflict of interest.

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Authors and Affiliations

  1. 1.Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der IsarTechnical University of MunichMunichGermany
  2. 2.DZHK (German Centre for Cardiovascular Research)—Partner Site Munich Heart AllianceMunichGermany

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