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Channelopathies in Heart Disease

Introduction and Book Overview
  • Carol Ann Remme
  • Dierk Thomas
Chapter
Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol.)

Abstract

The book “Channelopathies in Heart Disease” provides a translational overview of current state-of-the art research on ion channel (dys)function, cardiac channelopathies, and inherited arrhythmia syndromes. The latest insight on the structure and function of cardiac ion channels and the pro-arrhythmic consequences of their dysfunction is presented. Clinical and genetic characteristics of various inherited channelopathies and arrhythmia syndromes are discussed, in addition to new technologies available to this translational research field.

Keywords

Arrhythmogenesis Atrial fibrillation Electrophysiology Genetics Ion channel Ventricular arrhythmia 

Notes

Compliance with Ethical Standards

Sources of Funding

This work was funded by a Priority Medicines Rare Diseases and Orphan Drugs grant (PM-Rare, 113303006 to C.A.R.) from The Netherlands Organization for Health Research and Development (ZonMw) and an Innovational Research Incentives Scheme Vidi grant from ZonMw (grant no. 91714371 to C.A.R.), by the German Cardiac Society and the Hengstberger Foundation (Klaus-Georg and Sigrid Hengstberger Scholarship to D.T.), the German Heart Foundation/German Foundation of Heart Research (F/08/14 to D.T.), the Joachim Siebeneicher Foundation (to D.T.), and the Baden-Wuerttemberg Ministry of Science, Research and Art (Sonderlinie Medizin to D.T.).

Conflict of Interest

C.A.R. has previously received research grants from Gilead Sciences. D.T. reports receiving lecture fees/honoraria from Bayer Vital, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Medtronic, Pfizer Pharma, Sanofi-Aventis, St. Jude Medical, and ZOLL CMS and research grant support from Daiichi Sankyo. D.T. filed a patent application for the use of K2P potassium channels for altering cardiac electrophysiology.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Reference

  1. Shah M, Akar FG, Tomaselli GF. Molecular basis of arrhythmias. Circulation. 2005;112:2517–29.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Dept. of Clinical & Experimental CardiologyAcademic Medical Center, University of AmsterdamAmsterdamThe Netherlands
  2. 2.Department of Cardiology and HCR (Heidelberg Center for Heart Rhythm Disorders)University Hospital HeidelbergHeidelbergGermany
  3. 3.DZHK (German Centre for Cardiovascular Research)partner site Heidelberg/Mannheim, HeidelbergGermany

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