Breast Cancer Metabolism
Despite advances in screening, therapy, and surveillance that have improved survival rates, breast cancer is still the most commonly diagnosed cancer and the second leading cause of cancer mortality among women . Breast cancer is a highly heterogeneous disease rooted in a genetic basis and reflected in clinical behavior. The diversity of breast cancer hormone receptor status and the expression of surface molecules has guided therapy decisions for decades; however, subtype-specific treatment often yields diverse responses due to varying tumor evolution and malignant potential. Although understanding the mechanisms behind breast cancer heterogeneity is still a challenge, available evidence suggests that studying its metabolism has the potential to give valuable insight into the causes of these variations, as well as viable targets for intervention.
KeywordsBreast cancer Estrogen receptor status Metabolic fingerprint Choline metabolism Estrogen metabolism Serine biosynthesis Glycolytic upregulation
Glutathione S-transferase P
Human epidermal growth factor receptor 2
Phosphoserine aminotransferase 1
Triple-negative breast cancer
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