Conclusions and Future Directions

  • Kieran L. HudsonEmail author
Part of the Springer Theses book series (Springer Theses)


To summarise the first part of this thesis, I have demonstrated the utility of protein X-ray crystal structures containing carbohydrates as a source of information on PCIs. I generated a database of coordinates of carbohydrate residues and proximal amino acids from structures in the PDB (Berman et al., Nucl Acids Res 28:235–242, 2000, [1]), with the carbohydrates identified using GlyVicinity, (Lütteke and Frank, Nucl Acids Res 33:D242–D246, 2005, [2]) and the quality of the data validated using Privateer (Agirre et al., Nat Struct Mol Biol 22:833–834, 2015, [3]). Analysis of the distribution of amino acids in the carbohydrate binding sites, and particularly comparison of the distributions around different monosaccharides, are powerful tools for understanding carbohydrate-based interactions at the molecular level.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of British ColumbiaVancouverCanada

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