Suspension Anti-Streptolysin-O (ASO/ASL) Test
Group A streptococcus can cause several diseases that range from mild pharyngitis and impetigo to severe post-streptococcal sequelae. Group A streptococcus produces super-antigens such as streptolysin O (SLO). Group A streptococcus can activate the immune system to produce antibodies specific to SLO. Therefore, clinical laboratories confirm previous and existing group A streptococcus infections by detecting SLO-specific antibodies in patient’s serum. Here, the principle, applications, reagents, steps, and results interpretation process of the most commonly used test in clinical laboratories to detect SLO antibodies are explored.
KeywordsGAS Streptococcus pyogenes Super-antigens Streptolysin O Anti-streptolysin O Latex agglutination
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