Atopic Dermatitis: Overview

  • Benjamin T. Prince
  • Rekha RaveendranEmail author


Atopic dermatitis (AD) is a chronic, relapsing, and pruritic disease that classically develops in early childhood. There appears to be many contributing factors in the development of this disease including both genetic and environmental interactions, which ultimately lead to impaired epidermal barrier function and immune dysregulation. AD has a variable presentation depending upon age, and the diagnosis is based on clinical history and diagnostic characteristics. When making the diagnosis of AD, it is important to exclude conditions that present with similar erythematous, scaling, and pruritic rashes. The mainstay of treatment focuses on the maintenance of the skin barrier through pharmacological and/or non-pharmacological means. In this chapter, we will review important factors in making the diagnosis and treatment options. We will also discuss common pitfalls that occur in the management of this disease.


Atopic dermatitis Eczema Pruritus Topical corticosteroids Topical calcineurin inhibitors Antihistamines Immunosuppressants Dupilumab 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Allergy and ImmunologyNationwide Children’s HospitalColumbusUSA
  2. 2.Department of Otolaryngology, Division of Allergy and ImmunologyThe Ohio State University Wexner Medical CenterColumbusUSA

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