Dynamic Structures of the Nuclear Pore Complex and Their Roles in Nucleocytoplasmic Transport
The structure of the NPC has been studied for over 60 years. Although we are beginning to understand its structural framework, we do not know how the structure acts as a selective gate and how it facilitates transport in either direction. This may be because the very components that directly facilitate gating are varied, dynamic and possibly amorphous. Here, what we know about the structural organisation of the peripheral and dynamic components, such as the cytoplasmic filaments, the NPC basket and the structures within and protruding from the central channel, is reviewed in relation to their roles in nuclear transport.
Thanks to Christine Richardson for Fig. 3.4. Work was supported by Biotechnology and Biological Sciences Research Council, UK (grant numbers BB/E015735/1 and BB/G011818/1).
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