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Von Willebrand Disease in Pregnancy

  • Thomas G. DeLoughery
Chapter

Abstract

Von Willebrand disease is the most common bleeding disorder in women. There are three major types—type 1 with low levels of Von Willebrand factor (VWF), type 2 with abnormal VWF, and type 3 with no detectible WVF. Laboratory testing consists of checking factor VIII, VWF antigen, and VWF activity. Much controversy exists over diagnosis of VWD especially in patients with only moderately low levels. Treatment varies by disease type but ranges from desmopressin to use of VWF concentrates. An important feature of VWD in women is that estrogen administration can raise levels.

Keywords

Von Willebrand factor Desmopressin Cryoprecipitate Factor VIII 

Further Reading

  1. 1.
    DeLoughery TG. Von Willebrand disease. Chapter 5. In:Hemostasis and thrombosis (Vademecum). 2nd ed. Switzerland: Springer; 2003. p. 37–42.Google Scholar
  2. 2.
    DeLoughery TG. Bleeding and thrombosis: Women’s issues. In: TD DL, editor. Hemostasis and thrombosis. Switzerland: Springer; 2015. p. 51–5.Google Scholar
  3. 3.
    Leebeek FW, Eikenboom JC. Von Willebrand's disease. N Engl J Med. 2016;375(21):2067–80.CrossRefPubMedGoogle Scholar
  4. 4.
    Lillicrap D. von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy. Blood. 2013;122(23):3735–40.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Ng C, Motto DG, Di Paola J. Diagnostic approach to von Willebrand disease. Blood. 2015;125(13):2029–37.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Pacheco LD, Costantine MM, Saade GR, Mucowski S, Hankins GD, Sciscione AC. von Willebrand disease and pregnancy: a practical approach for the diagnosis and treatment. Am J Obstet Gynecol. 2010;203(3):194–200.CrossRefPubMedGoogle Scholar
  7. 7.
    Springer TA. von Willebrand factor, Jedi knight of the bloodstream. Blood. 2014;124(9):1412–25.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Oregon Health & Science UniversityPortlandUSA

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