Lenalidomide for the Treatment of MDS
Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematopoietic disorders characterized by bone marrow (BM) failure, dysplasia, and an increased risk of developing acute myeloid leukemia (AML) . The most prevalent cytogenetic abnormality is a partial deletion of the long arm of chromosome 5, del(5q), which is present in about 15% of cases . Anemia is the predominant cytopenia in the large majority of low-risk MDS cases, being the focus of most therapeutic interventions. It often requires repeated RBC transfusions, leading to potential iron overload.
This work was in part supported by the Deutsche José Carreras Leukämie-Stiftung.
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