Emerging Concepts in Treating Cartilage, Osteochondral Defects, and Osteoarthritis of the Knee and Ankle

  • Hélder Pereira
  • Ibrahim Fatih Cengiz
  • Carlos Vilela
  • Pedro L. Ripoll
  • João Espregueira-Mendes
  • J. Miguel Oliveira
  • Rui L. Reis
  • C. Niek van Dijk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1059)


The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches. This work addresses the state of the art concerning basic science comparing the knee and ankle as well as current options for treatment. Furthermore, the most promising research developments promising new options for the future are discussed.


Surgery Autologous osteochondral transplantation Bone marrow stimulation Congruency Alignment Tissue engineering and regenerative medicine 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Hélder Pereira
    • 1
    • 2
    • 3
    • 4
    • 5
  • Ibrahim Fatih Cengiz
    • 3
    • 4
  • Carlos Vilela
    • 3
    • 4
  • Pedro L. Ripoll
    • 2
    • 5
  • João Espregueira-Mendes
    • 3
    • 4
    • 6
    • 7
    • 8
  • J. Miguel Oliveira
    • 3
    • 4
    • 9
  • Rui L. Reis
    • 3
    • 4
    • 9
  • C. Niek van Dijk
    • 5
    • 10
  1. 1.Orthopedic Department Centro Hospitalar Póvoa de VarzimVila do CondePortugal
  2. 2.International Centre of Sports Traumatology of the AveTaipasPortugal
  3. 3.3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da GandraBarco, GuimarãesPortugal
  4. 4.ICVS/3B’s – PT Government Associate LaboratoryBraga, GuimarãesPortugal
  5. 5.Ripoll y De Prado Sports Clinic: Murcia – Madrid FIFA Medical Centre of ExcellenceMadridSpain
  6. 6.Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of ExcellencePortoPortugal
  7. 7.Dom Henrique Research CentrePortoPortugal
  8. 8.Orthopedic Department, University of MinhoBragaPortugal
  9. 9.The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of MinhoGuimarãesPortugal
  10. 10.Department of Orthopaedic Surgery and Academic Center for Evidence-Based Sports Medicine, Academic Medical CenterUniversity of Amsterdam, Amsterdam Movement SciencesAmsterdamThe Netherlands

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