Multiple Coagulation Factor Deficiency

  • Maryam Sadat Hosseini
  • Mahmood Shams
  • Akbar Dorgalaleh
  • Hassan Mansouritorghabeh


Bleeding disorders with low plasma activity of more than one coagulation factor have been described in several conditions. Multiple coagulation factor deficiency (MCFD) commonly represents as part of acquired conditions. The most well-known acquired causes are liver disease and disseminated intravascular coagulation (DIC) in which impaired synthesis or excessive consumption of coagulation factors occurs, respectively. Dilution states such as massive transfusion and cardiopulmonary bypass are also considered as conditions which lead to MCFD. Congenital deficiencies of more than one coagulation factor rarely have been also described. Such disorders can be rare autosomal bleeding disorder with extremely low incidence. Congenital MCFD may arise from coinheritance of isolated factor defects or may be a result of a single genetic defect. The latter which comprises most of cases is generally caused by defect of a single gene that is implicated in the process or production/activation of multiple factors. The best examples include combined FV and FVIII deficiency (F5F8D) and vitamin K-dependent coagulation factors (VKDCF) deficiency, which have been thoroughly characterized. Isolated combined coagulation factor deficiencies are extremely rare disorders and restricted to isolated case reports.


Combined FV and FVIII deficiency Vitamin K-dependent coagulation factor deficiency Multiple coagulation factor deficiencies Rare bleeding disorders 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Maryam Sadat Hosseini
    • 1
  • Mahmood Shams
    • 2
    • 3
  • Akbar Dorgalaleh
    • 3
  • Hassan Mansouritorghabeh
    • 4
  1. 1.Department of Hematology and Blood transfusionSchool of Allied Medicine, Shahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Laboratory Sciences, Paramedical FacultyBabol University of Medical SciencesBabolIran
  3. 3.Department of Hematology and Blood transfusionSchool of Allied Medicine, Iran University of Medical SciencesTehranIran
  4. 4.Allergy Research CenterSchool of Medicine, Mashhad University of Medical SciencesMashhadIran

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