Gellan Gum-Based Hydrogels for Osteochondral Repair

  • Lígia Costa
  • Joana Silva-Correia
  • J. Miguel Oliveira
  • Rui L. Reis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1058)


Gellan gum (GG) is a widely explored natural polysaccharide that has been gaining attention in tissue engineering (TE) and regenerative medicine field, and more recently in osteochondral TE approaches. Taking advantage of its inherent features such as biocompatibility, biodegradability, similarity with the extracellular matrix and easy functionalization, GG-based hydrogels have been studied for their potential for cartilage and bone tissue regeneration. Several preclinical studies describe the successful outcome of GG in cartilage tissue engineering. By its turn, GG composites have also been proposed in several strategies to guide bone formation. The big challenge in osteochondral TE approaches is still to achieve cartilage and bone regeneration simultaneously through a unique integrated bifunctional construct. The potential of GG to be used as polymeric support to reach both bone and cartilage regeneration has been demonstrated. This chapter provides an overview of GG properties and the functionalization strategies employed to tailor its behaviour to a particular application. The use of GG in soft and hard tissues regeneration approaches, as well in osteochondral integrated TE strategies is also revised.


Gellan gum Osteochondral Cartilage Bone Bilayered scaffolds 



The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for the funds obtained through the project B-FABULUS (PTDC/BBB-ECT/2690/2014) and the financial support provided to Joaquim M. Oliveira (IF/01285/2015) and Joana Silva-Correia (IF/00115/2015) under the programme “Investigador FCT.”


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Lígia Costa
    • 1
    • 2
  • Joana Silva-Correia
    • 1
    • 2
  • J. Miguel Oliveira
    • 1
    • 2
    • 3
  • Rui L. Reis
    • 1
    • 2
    • 3
  1. 1.3Bs Research Group—Biomaterials, Biodegradables and Biomimetics, European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of MinhoBarco GMRPortugal
  2. 2.ICVS/3B’s—PT Government Associate LaboratoryBraga/GuimarãesPortugal
  3. 3.The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 BarcoGuimarãesPortugal

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