Natural Origin Materials for Osteochondral Tissue Engineering

  • Walter BonaniEmail author
  • Weerasak Singhatanadgige
  • Aramwit Pornanong
  • Antonella Motta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1058)


Materials selection is a critical aspect for the production of scaffolds for osteochondral tissue engineering. Synthetic materials are the result of man-made operations and have been investigated for a variety of tissue engineering applications. Instead, the products of physiological processes and the metabolic activity of living organisms are identified as natural materials. Over the recent decades, a number of natural materials, namely, biopolymers and bioceramics, have been proposed as the main constituent of osteochondral scaffolds, but also as cell carriers and signaling molecules. Overall, natural materials have been investigated both in the bone and in the cartilage compartment, sometimes alone, but often in combination with other biopolymers or synthetic materials. Biopolymers and bioceramics possess unique advantages over their synthetic counterparts due similarity with natural extracellular matrix, the presence of cell recognition sites and tunable chemistry. However, the characteristics of natural origin materials can vary considerably depending on the specific source and extraction process. A deeper understanding of the relationship between material variability and biological activity and the definition of standardized manufacturing procedures will be crucial for the future of natural materials in tissue engineering.


Proteins Polysaccharides Polyhydroxyalkanoates Bioceramics Osteochondral tissue engineering 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Walter Bonani
    • 1
    Email author
  • Weerasak Singhatanadgige
    • 2
  • Aramwit Pornanong
    • 3
  • Antonella Motta
    • 1
  1. 1.BIOtech Research Center and Department of Industrial EngineeringEuropean Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of TrentoTrentoItaly
  2. 2.Department of Orthopedic Surgery, Faculty of MedicineChulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross SocietyBangkokThailand
  3. 3.Bioactive Resources for Innovative Clinical Applications Research Unit and Department of Pharmacy Practice, Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkokThailand

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