Measurements of Antihypertensive Medications in Blood and Urine
Biochemical detection of antihypertensive medications in blood and urine is a recent addition to the diagnosis of therapeutic non-adherence. The biochemical analysis by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides a direct, objective and robust confirmation of the presence or absence of prescribed antihypertensive medications in bodily fluids. This chapter covers the laboratory principles and the clinical aspects of the biochemical screening for therapeutic non-adherence in management of hypertension.
KeywordsBiochemical screening Adherence Non-adherence Liquid chromatography mass spectrometry Hypertension Cardiovascular disease Blood pressure
The authors are grateful to Dan Lane in the Department of Chemical Pathology and Metabolic Disease, Leicester Royal Infirmary who prepared the illustrations used in this chapter. Our work on adherence is supported by British Heart Foundation Clinical Study (CS/17/3/32799).
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