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Hematologic and Lymphoid Neoplasia

  • Anne Tierens
  • William Geddie
Chapter

Abstract

Primary lymphomas presenting in body cavities are rare. The WHO classification of lymphoid neoplasms recognizes three disease entities, including primary effusion lymphoma (PEL), diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI), and breast implant-associated anaplastic large-cell lymphoma (BI-ALCL). PEL is a human herpesvirus 8 (HHV8)-positive lymphoproliferative disorder with plasmacytoid differentiation, often occurring in immune-compromised individuals or HIV patients. It primarily presents in the pleural cavity but may involve other cavities and extranodal sites. The differential diagnosis of PEL is the HHV8-negative effusion-based DLBCL affecting elderly, immune-competent patients with underlying conditions leading to fluid overload such as cirrhosis, cardiomyopathy, and protein-losing enteropathy. Pyothorax-associated lymphoma (PAL), described in tuberculosis patients with long-standing pyothorax, is the best characterized DLBCL-CI. It derives from EBV-transformed B-cells which are frequently positive for MYC amplification and TP53 mutations. PAL has become rare, but DLBCL-CI associated with chronic osteomyelitis and skin ulcers has been identified. BI-ALCL is a CD30-positive T-cell lymphoma occurring in women with breast implants. It usually presents as an encapsulated seroma fluid and seldom as a solid tumor. Unlike PEL and DLBCL-CI, BI-ALCL is an indolent disease with long-term survival upon surgery only. Other lymphomas, such as nasal-type NK/T-cell lymphomas, adult T-cell leukemia/lymphoma, and extranodal marginal zone lymphoma, may occasionally manifest in body cavities. Secondary infiltration of the pleural cavity is a common complication of lymphoblastic lymphoma, Burkitt’s lymphoma and T-cell lymphoma. In contrast, myeloid leukemic effusions are rare.

Keywords

Effusion Lymphoma HHV8 Implant Inflammation 

References

  1. 1.
    Alexandrakis MG, Passam FH, Kyriakou DS, Bouros D. Pleural effusions in hematologic malignancies. Chest. 2004;125:1546–55.CrossRefPubMedGoogle Scholar
  2. 2.
    Das DK. Serous effusions in malignant lymphomas: a review. Diagn Cytopathol. 2006;34:335–47.CrossRefPubMedGoogle Scholar
  3. 3.
    Wong JW, Pitlik D, Abdul-Karim FW. Cytology of pleural, peritoneal and pericardial fluids in children. A 40-year summary. Acta Cytol. 1997;41:467–73.CrossRefPubMedGoogle Scholar
  4. 4.
    Van Renterghem DM, Pauwels RA. Chylothorax and pleural effusion as late complications of thoracic irradiation. Chest. 1995;108:886–7.CrossRefPubMedGoogle Scholar
  5. 5.
    Brixey AG, Light RW. Pleural effusions due to dasatinib. Curr Opin Pulm Med. 2010;16:351–65.CrossRefPubMedGoogle Scholar
  6. 6.
    Seber A, Khan SP, Kersey JH. Unexplained effusions: association with allogeneic bone marrow transplantation and acute or chronic graft-versus-host disease. Bone Marrow Transplant. 1996;17:207–11.PubMedGoogle Scholar
  7. 7.
    Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127:2375–90.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Thompson PA, Lade S, Webster H, Ryan G, Prince HM. Effusion-associated anaplastic large cell lymphoma of the breast: time for it to be defined as a distinct clinico-pathological entity. Haematologica. 2010;95:1977–9.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Alexanian S, Said J, Lones M, Puliarkat ST. KSHV/HHV8-negative Effusion-based lymphoma, a distinct entity with fluid overload states. Am J Surg Pathol. 2013;37:241–9.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Mitchell A, Meunier C, Ouellette D, Colby T. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with initial presentation in the pleura. Chest. 2006;129:791–4.CrossRefPubMedGoogle Scholar
  11. 11.
    Motta G, Conticello C, Amato G, Moschetti G, Colarossi C, Cosentino S, Ippolito M, Giustolisi R, Di Raimondo F. Pleuric presentation of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a case report and a review of the literature. Int J Hematol. 2010;92:369–73.CrossRefPubMedGoogle Scholar
  12. 12.
    Pullarkat VA, Medeiros LJ, Brynes RK. Body cavity-based presentation of natural killer cell lymphoma. Leuk Lymphoma. 2005;46:293–6.CrossRefPubMedGoogle Scholar
  13. 13.
    Chaves FP, Quillen K, Xu D. Pericardial effusion: a rare presentation of adult T-cell leukemia/lymphoma. Am J Hematol. 2004;77:381–3.CrossRefPubMedGoogle Scholar
  14. 14.
    Czader M, Ali SZ. Flow cytometry as an adjunct to cytomorphologic analysis of serous effusions. Diagn Cytopathol. 2003;29:74–8.CrossRefPubMedGoogle Scholar
  15. 15.
    Bangerter M, Brudler O, Heinrich B, Griesshamnuer M. Fine needle aspiration cytology and flow cytometry in the diagnosis and subclassification of non-Hodgkin’s lymphoma based on the World Health Organization classification. Acta Cytol. 2007;51:390–8.CrossRefPubMedGoogle Scholar
  16. 16.
    Evans PA, Pott C, Groenen PJ, Salles G, Davi F, Berger F, Garcia JF, van Krieken JH, Pals S, Kluin P, Schuuring E, Spaargaren M, Boone E, González D, Martinez B, Villuendas R, Gameiro P, Diss TC, Mills K, Morgan GJ, Carter GI, Milner BJ, Pearson D, Hummel M, Jung W, Ott M, Canioni D, Beldjord K, Bastard C, Delfau-Larue MH, van Dongen JJ, Molina TJ, Cabeçadas J. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936. Leukemia. 2007;21:207–14.CrossRefPubMedGoogle Scholar
  17. 17.
    Brüggemann M, White H, Gaulard P, Garcia-Sanz R, Gameiro P, Oeschger S, Jasani B, Ott M, Delsol G, Orfao A, Tiemann M, Herbst H, Langerak AW, Spaargaren M, Moreau E, Groenen PJ, Sambade C, Foroni L, Carter GI, Hummel M, Bastard C, Davi F, Delfau-Larue MH, Kneba M, van Dongen JJ, Beldjord K, Molina TJ. Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies. Report of the BIOMED-2 Concerted Action BHM4 CT98-3936. Leukemia. 2007;21:215–21.CrossRefPubMedGoogle Scholar
  18. 18.
    Tong LC, Ko HM, Saig MA, Boerner S, Geddie WR, da Cunha Santos G. Subclassification of lymphoproliferative disorders in serous effusions: a 10 year experience. Cancer Cytopathol. 2013;121:261–70.CrossRefPubMedGoogle Scholar
  19. 19.
    Langerak AW, Molina TJ, Lavender FL, Pearson D, Flohr T, Sambade C, Schuuring E, Al Saati T, van Dongen JJ, van Krieken JH. Polymerase chain reaction-based clonality testing in tissue samples with reactive lymphoproliferations: usefulness and pitfalls. A report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2007;21:222–9.CrossRefPubMedGoogle Scholar
  20. 20.
    Mann G, Attarbaschi A, Steiner M, Simonitsch I, Strobl H, Urban C, Meister B, Haas O, Dworzak M, Gadner H. Austrian Berlin-Frankfurt-Münster (BFM) Group. Early and reliable diagnosis of non-Hodgkin lymphoma in childhood and adolescence: contribution of cytomorphology and flow cytometric immunophenotyping. Pediatr Hematol Oncol. 2006;2:167–76.CrossRefGoogle Scholar
  21. 21.
    Mathiot C, Decaudin D, Klijanienko J, Couturier J, Salomon A, Dumont J, Vielh P. Fine-needle aspiration cytology combined with flow cytometry immunophenotyping is a rapid and accurate approach for the evaluation of suspicious superficial lymphoid lesions. Diagn Cytopathol. 2006;34:472–8.CrossRefPubMedGoogle Scholar
  22. 22.
    Mathur S, Dawar R, Diagnosis VK. Grading of non-Hodgkin's lymphomas on fine needle aspiration cytology. Indian J Pathol Microbiol. 2007;50:46–50.Google Scholar
  23. 23.
    Knowles DM, Inghirami G, Ubriaco A, Dalla-Favera R. Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrated their B-cell derivation and the possible pathogenetic role of the Epstein Bar virus. Blood. 1989;108:792–9.Google Scholar
  24. 24.
    Walts AE, Shintaku IP, Said JW. Diagnosis of malignant lymphoma in effusions from patients with AIDS by gene rearrangements. Am J Clin Pathol. 1990;94:170–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Chadburn A, Cesarman E, Jagirdar J, Subar M, Mir RN, Knowles DM. CD30 (Ki-1) positive anaplastic large cell lymphomas in individuals infected with the human immunodeficiency virus. Cancer. 1993;72:3078–90.CrossRefPubMedGoogle Scholar
  26. 26.
    Green I, Espiritu E, Ladanyi M, Chaponda R, Wieczorek R, Gallo L, Feiner H. Primary lymphomatous effusions in AIDS: a morphological, immunophenotypic, and molecular study. Mod Pathol. 1995;8:39–45.PubMedGoogle Scholar
  27. 27.
    Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Said J, Knowles DM. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi’s sarcoma-associated herpes virus. Blood. 1996;88:645–56.PubMedGoogle Scholar
  28. 28.
    Chadburn A, Hyjek E, Mathew S, Cesarman E, Said J, Knowles DM. KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma. Am J Surg Pathol. 2004;28:1401–16.CrossRefPubMedGoogle Scholar
  29. 29.
    DePond W, Said JW, Tasaka T, de Vos S, Kahn D, Cesarman E, Knowles DM, Koeffler HP. Kaposi’s sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas. Am J Surg Pathol. 1997;21:719–24.CrossRefPubMedGoogle Scholar
  30. 30.
    Chadburn A, Said J, Gratzinger D, Chan JKC, de Jong DE, Jaffe E, Natkunam Y, Goodlad JR. HHV8/KSHV-positive lymphoproliferative disorders and the spectrum of plasmablastic cell neoplasms. Am J Clin Pathol. 2017;147:171–87.CrossRefPubMedGoogle Scholar
  31. 31.
    Carbone A, Gloghini A, Vaccher E, Marchetti G, Gaidano G, Tirelli U. KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects: report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype. J Clin Pathol. 2005;58:1039–45.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC. Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998;339:444–9.CrossRefPubMedGoogle Scholar
  33. 33.
    Dotti G, Fiocchi R, Motta T, Facchinetti B, Chiodini B, Borleri GM, Gavazzeni G, Barbui T, Rambaldi A. Primary effusion lymphoma after heart transplantation: a new entity associated with human herpesvirus-8. Leukemia. 1999;13:664–70.CrossRefPubMedGoogle Scholar
  34. 34.
    Du MQ, Bacon CM, Isaacson PG. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders. J Clin Pathol. 2007;60:1350–7.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science. 1994;266:1865–9.CrossRefGoogle Scholar
  36. 36.
    Polskj JM, Evans HL, Grosso LE, Popovic WJ, Taylor L, Dunphy CH. CD7 and CD56-positive primary effusion lymphoma in a human immunodeficiency virus-negative host. Leuk Lymphoma. 2000;39:633–9.CrossRefPubMedGoogle Scholar
  37. 37.
    Matolcsy A, Nador RG, Cesarman E, Knowles DM. Immunoglobulin VH gene mutation analysis suggests that primary effusions derive from different stages of B cell maturation. Am J Pathol. 1998;153:1609–14.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Kelin U, Gloghini A, Gaidano G, Chadburn A, Cesarman E, Dalla-Favera R, Carbone A. gene expression profile analysis of AIDS-rleated primary effusions lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts. Blood. 2003;101:4115–21.CrossRefGoogle Scholar
  39. 39.
    Jenner RG, Mailland K, Catttini N, Weiss RA, Boshoff C, Wooster R, Kellam P. Kaposi’s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile. Proc Natl Acad Sci U S A. 2003;100:10399–404.CrossRefPubMedPubMedCentralGoogle Scholar
  40. 40.
    Wilson KS, McKenna RW, Kroft SH, Dawson DB, Ansari Q, Schneider NR. Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities. Br J Haematol. 2002;116:113–21.CrossRefGoogle Scholar
  41. 41.
    Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zableta J, Qin Z. Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma. Blood. 2015;126:2821–31.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Lam BQ, Dai L, LI L, Qiao J, Lin Z, Qin Z. Molecular mechanisms of activating c-MET in KSHV+ primary effusion lymphoma. Oncotarget. 2017;8:18373–80.PubMedPubMedCentralGoogle Scholar
  43. 43.
    Chen YB, Rahemtullah A, Hochberg E. Primary effusion lymphoma. Oncologist. 2007;12:569–76.CrossRefPubMedGoogle Scholar
  44. 44.
    Iuchi K, Ichimiya A, Akashi A, Mizuta T, Lee YE, Tada H, Mori T, Sawamura K, Lee YS, Furuse K, Yamamoto S, Aozasa K. Non-Hodgkin’s lymphoma of the pleural cavity developing from long-standing pyothorax. Cancer. 1987;60:1771–5.CrossRefPubMedGoogle Scholar
  45. 45.
    Aozasa K. Pyothorax-associated lymphoma. J Clin Exp Hematop. 2006;46:5–10. ReviewCrossRefPubMedGoogle Scholar
  46. 46.
    Petitjean B, Jardin F, Joly B, Martin-Garcia N, Tilly H, Picquenot JM, Briere J, Danel C, Mehaut S, Abd-Al-Samad I, Copie-Bergman C, Delfau-Larue MH, Gaulard P. Pyothorax-associated lymphoma. A peculiar clinicopathologic entity derived from B cells at late stage of differentiation and with occasional aberrant dual B- and T- cell phenotype. Am J Surg Pathol. 2002;26:724–32.CrossRefPubMedGoogle Scholar
  47. 47.
    Nakatsuka S, Yao M, Hoshida Y, Yamamoto S, Iuchi K, Aozasa K. Pyothorax-associated lymphoma: a review of 106 cases. J Clin Oncol. 2002;20:4255–60.CrossRefPubMedGoogle Scholar
  48. 48.
    Fukayama M, Ibuka T, Hayashi Y, Ooba T, Koike M, Mizutani S. Epstein-Barr virus in pyothorax-associated pleural lymphoma. Am J Pathol. 1993;143:1044–9.PubMedPubMedCentralGoogle Scholar
  49. 49.
    Aosaza K, Takkuwa T, Nakatsuka S. Pyothorax-associated lymphoma. A lymphoma developing in chronic inflammation. Adv Anat Pathol. 2005;12:324–31. ReviewCrossRefGoogle Scholar
  50. 50.
    Hongyo T, Kurooka M, Taniguchi E, Iuchi K, Nakajima Y, Aozasa K, Nomura T. Frequent p53 mutations at dipyrimidine sites in patients with pyothorax-associated lymphoma. Cancer Res. 1998;58:1105–57.PubMedGoogle Scholar
  51. 51.
    Boyer D, Mc Kelvie PA, de Leval L, Edlefsen KL, Ko YH, Aberman ZA, Kovach AE, Masih A, Nishino HT, Weiss LM, Meeker AK, Nardi V, Palisoc M, Shao L, Pittalagu S, Ferry JA, Harris NL, Sohani AR. Fibrin-associated EBV-positive B-cell lymphoma. An indolent neoplasm with features distinct from diffuse large B-cell lymphoma associated with chronic inflammation. Am J Surg Pathol. 2017;41:299–312.CrossRefPubMedGoogle Scholar
  52. 52.
    Keech JA, Creech BJ. Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg. 1997;100:554–5.CrossRefPubMedGoogle Scholar
  53. 53.
    Gaudet G, Friedberg JW, Weng A, Pinkus GS, Freedman AS. Breast lymphoma associated with breast implants: two case-reports and a review of the literature. Leuk Lymphoma. 2002;43:115–9.CrossRefPubMedGoogle Scholar
  54. 54.
    de Jong D, Vasmel WL, de Boer JP, Verhave G, Barbé E, Casparie MK, van Leeuwen FE. Anaplastic large-cell lymphoma in women with breast implants. JAMA. 2008;300:2030–5.CrossRefPubMedGoogle Scholar
  55. 55.
    Xu J, Wei S. Breast-implant-associated anaplastic large cell lymphoma. Review of a distinct clinicopathologic entity. Arch Pathol Lab Med. 2014;138:842–6.CrossRefPubMedGoogle Scholar
  56. 56.
    Laurent C, Delas A, Gaulard P, Haioun C, Moreau A, Xerri L, Traverse-Glehen A, Rousset T, Quintin-Roue I, Petrella T, Emile JF, Amara N, Rochaix P, Chenard-Neu MP, Tasei AM, Menet E, Chomarat H, Costes V, Andrac-Meyer L, Michiels JF, Chassagne-Clement C, de Leval L, Brousset P, Delsol G, Lamant L. Breast implant associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes. Ann Oncol. 2016;27:306–14.CrossRefPubMedGoogle Scholar
  57. 57.
    Miranda RN, Aladily TN, Prince HM, Kanagal-Shamanna R, de Jong D, Fayad LE, Amin MB, Haideri N, Bhagat G, Brooks GS, Shifrin DA, O'Malley DP, Cheah CY, Bacchi CE, Gualco G, Li S, Keech JA Jr, Hochberg EP, Carty MJ, Hanson SE, Mustafa E, Sanchez S, Manning JT Jr, Xu-Monette ZY, Miranda AR, Fox P, Bassett RL, Castillo JJ, Beltran BE, de Boer JP, Chakhachiro Z, Ye D, Clark D, Young KH, Medeiros LJ. Breast implant-associated anaplastic large cell lymphoma: long term follow-up of 60 patients. J Clin Oncol. 2014;32:2375–90.Google Scholar
  58. 58.
    Clemens MW, Medeiros LJ, Butler CE, Hunt KK, Fanale MA, Horwitz S, Weisenburger DD, Liu J, Morgan EA, Kanagal-Shamanna R, Parkash V, Ning J, Sohani AR, Ferry JA, Mehta-Shah N, Dogan A, Liu H, Thormann N, Di Naopli A, Lade S, Piccolini J, Reyes R, Williams T, McCarthy CM, Hanson SE, Nastoupil LJ, Gaur R, Oki Y, Young KH, Miranda RN. Complete surgical excision is essential for the management of patients with brest implant-associated anaplastic large cell lymphoma. J Clin Oncol. 2016;34:160–8.CrossRefPubMedGoogle Scholar
  59. 59.
    Lipworth L, Tarone RE, McLaughlin JK. Breast implants and lymphoma risk: a review of the epidemiologic evidence through 2008. Plast Reconstr Surg. 2009;123:790–3.CrossRefPubMedGoogle Scholar
  60. 60.
    Di Napoli A, Jain P, Duranti E, Margolskee E, Arancio W, Fachetti F, Alobeid B, di Pompeo FS, Mansukhani M, Bhagat G. Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signaling pathway genes, TP53 and DNMT3A. Br J Haematol. 2016.  https://doi.org/10.1111/bjh.14431.
  61. 61.
    Blombery P, Thompson E, Jones K, Mir Arnau MG, Lade S, Markham JE, Li J, Deva A, Johnstone RW, Khot A, Prince HM, Westerman D. Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma. Haematologica. 2016;101:e387–90.CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Crescenzo R, Abate F, Lasorsa E, Tabbo F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barbarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficarro E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Tzankov A, Pnozoni M, Paulli M, weisenburger D, Chan WC, Iqbal J, Piris MA, Zamo A, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Schultz LD, Mevellec L, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G. Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma. Cancer Cell. 2015;27:516–32.CrossRefPubMedPubMedCentralGoogle Scholar
  63. 63.
    Yang L, Rau R, Goodell MA. DNMT3A in hematological malignancies. Nat Rev Cancer. 2015;15:152–65.CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Wu D, Allen CT, Fromm JR. Flow cytometry of ALK-negative anaplastic large cell lymphoma of breast implant-associated effusion and capsular tissue. Cytometry B. 2015;88B:58–63.CrossRefGoogle Scholar
  65. 65.
    Montgomery-Goecker C, Fuda F, Krueger JE, Chen W. Immunophenotypic characteristics of breast implant-associated anaplastic large cell lymphoma by flow cytometry. Cytometry B. 2015;88B:291–3.CrossRefGoogle Scholar
  66. 66.
    Roden AC, Macon WR, Keeney GL, Myeres JL, Feldman AL, Dogan A. Seroma-associated primary anaplastic large cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder. Mod Pathol. 2008;21:455–63.CrossRefPubMedGoogle Scholar
  67. 67.
    Clemens MW, Horwitz SM. NCCN Consensus guidelines for the diagnosis and management of breast implant-associated anaplastic large cell lymphoma. Aesth Reconstr Surg. 2017;139:1029–39.CrossRefGoogle Scholar
  68. 68.
    Ichinohasama R, Miura I, Kobayashi N, Saitoh Y, DeCoteau JF, Saiki Y, Mori S, Kadin ME, Ooya K. Herpes virus type 8-negative primary effusion lymphoma associated with PAX-5 gene rearrangement and hepatitis C virus: a case report and review of the literature. Am J Surg Pathol. 1998;22:1528–37.CrossRefPubMedGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratory Medicine ProgramHematopathology, University Health NetworkTorontoCanada
  2. 2.Laboratory Medicine Program, CytopathologyUniversity Health NetworkTorontoCanada

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