Oropharynx, Hypopharynx, and Parapharyngeal Space: Anatomy, Histology, Benign and Malignant Neoplasia

  • Margaret S. Brandwein-Weber


The range of benign and malignant entities encountered in the oropharynx is much smaller, relative to the oral cavity and there are no “precursor” lesions in the oropharynx. The biology, morphology, treatment, and staging of oropharyngeal squamous carcinomas are vastly different than squamous carcinomas just centimeters anterior, in the oral cavity. High-risk Human Papillomavirus (HR-HPV) -mediated oropharyngeal cancers can be recognized by the following possible features: nonkeratinizing, “inside-out” maturation, and multinucleated and/pr pleomorphic tumor cells. Metastatic HR-HPV mediated oropharyngeal cancers are frequently cystic. Immunohistochemistry for p16 is now standard of care for staging oropharyngeal carcinomas according to new 8th American Joint Cancer Committee standards.


Waldeyer’s ring Reticulated epithelium Mucosal associated lymphoid tissue (MALT) Eagle’s syndrome Sistrunk procedure Well-differentiated lipoma-like liposarcoma/atypical lipomatous neoplasm MDM2 High-risk Human Papillomavirus. p16 E6 E7 Rb Cetuximab 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Margaret S. Brandwein-Weber
    • 1
  1. 1.Mount Sinai HospitalNew YorkUSA

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