• Ghazala Q. Sharieff


Omphalitis is an acute infection of the umbilical stump with an overall incidence of 0.2–0.7% in industrialized countries. This chapter highlights the classic features of omphalitis, discusses the common mimics, details the symptom course, and emphasizes key diagnostic and management guidelines. Complications and the differential diagnosis are also discussed.


Omphalitis Myonecrosis Necrotizing fasciitis Portal vein thrombosis Liver abscess Septic emboli 



The author would like to thank Aleena Shad, research assistant, for her help with this chapter.


  1. 1.
    Gallagher PG, Shah SS. Omphalitis: overview Available at 2008.
  2. 2.
    Ameh EA, Nmadu PT. Major complications of omphalitis in neonates and infants. Pediatr Surg Int. 2002;18:413–6.CrossRefPubMedGoogle Scholar
  3. 3.
    Brook I. Microbiology of necrotizing fasciitis associated with omphalitis in the newborn infant. J Perinatol. 1998;18(1):28–30.PubMedGoogle Scholar
  4. 4.
    Sawin RS, Schaller RT, Tapper D, et al. Early recognition of neonatal abdominal wall necrotizing fasciitis. Am J Surg. 1994;167(5):481–4.CrossRefPubMedGoogle Scholar
  5. 5.
    van Vliet DN, Brandsma AE, Hartwig NG. Leukocyte-adhesion deficiency: a rare disorder of inflammation. Ned Tijdschr Geneeskd. 2004;148(50):2496–500.PubMedGoogle Scholar
  6. 6.
    Alizadeh P, Rahbarimanesh AA, Bahram MG, Salmasian H. Leukocyte adhesion deficiency type 1 presenting as leukemoid reaction. Indian J Pediatr. 2007;74(12):1121–3.CrossRefPubMedGoogle Scholar
  7. 7.
    Parvaneh N, Mamishi S, Rezaei A, et al. Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. J Clin Immunol. 2010;30(5):756–60.CrossRefPubMedGoogle Scholar
  8. 8.
    Donadieu J, Fenneteau O, Beaupain B, Mahlaoui N, Chantelot CB. Congenital neutropenia: diagnosis, molecular bases and patient management. Orphanet J Rare Dis. 2011;6:26.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Razvi S, Murphy R, Shlasko E, Cunningham-Rundles C. Delayed separation of the umbilical cord attributable to urachal anomalies. Pediatrics. 2001;108(2):493–4.CrossRefPubMedGoogle Scholar
  10. 10.
    Masuko T, Nakayama H, Aoki N, Kusafuka T, Takayama T. Staged approach to the urachal cyst with infected omphalitis. Int Surg. 2006;91(1):52–6. Weber DM, Freeman NV, Elhag KM. Periumbilical necrotizing fasciitis in the newborn. Eur J Pediatr Surg 2001. 11(2):86–91PubMedGoogle Scholar
  11. 11.
    Nazir Z. Necrotizing fasciitis in neonates. Pediatr Surg Int. 2005;21(8):641–4.CrossRefPubMedGoogle Scholar
  12. 12.
    Bingol-Kologlu M, Yildiz RV, Alper B, et al. Necrotizing fasciitis in children: diagnostic and therapeutic aspects. J Pediatr Surg. 2007;42(11):1892–7.CrossRefPubMedGoogle Scholar
  13. 13.
    Orloff MJ, Orloff MS, Girard B, Orloff SL. Bleeding esophagogastric varices from extrahepatic portal hypertension: 40 years’ experience with portal-systemic shunt. J Am Coll Surg. 2002;194(6):717–28; discussion 728–30CrossRefPubMedGoogle Scholar
  14. 14.
    Feo CF, Dessanti A, Franco B, et al. Retroperitoneal abscess and omphalitis in young infants. Acta Paediatr. 2003;92(1):122–5.CrossRefPubMedGoogle Scholar
  15. 15.
    WHO. Guidelines on maternal, newborn, child and adolescent health: recommendations on newborn health. Available at Accessed: 5/2/2017.
  16. 16.
    Sinha A, Sazawal S, Pradhan A, Ramji S, Opiyo N. Chlorhexidine skin or cord care for prevention of mortality and infections in neonatesCochrane Database Syst Rev. 2015 3:CD007835.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ghazala Q. Sharieff
    • 1
    • 2
  1. 1.University of CaliforniaSan DiegoUSA
  2. 2.Scripps HealthSan DiegoUSA

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