Assessment with Cognitive Screening Instruments

  • A. J. Larner


This chapter examines the screening utility of selected cognitive screening instruments, including both multidomain and specific/single domain instruments, which have been examined in the author’s clinic for the assessment of cognitive complaints.


Dementia Diagnosis Cognitive screening instruments 


  1. Abdel-Aziz K, Larner AJ. Six-Item Cognitive Impairment Test (6CIT) for detection of dementia and cognitive impairment. Int Psychogeriatr. 2015;27:991–7.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Aji BM, Ghadiali EJ, Jacob A, Larner AJ. Passage of an iron bar through the head: 50-year follow-up. J Neurol. 2012;259:1247–8.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Aji BM, Medley G, O’Driscoll K, Larner AJ, Alusi SH. Perry syndrome: a disorder to consider in the differential diagnosis of parkinsonism. J Neurol Sci. 2013;330:117–8.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Aji BM, Milburn-McNulty P, Larner AJ. Epilepsy: when family history holds the key to diagnosis. Prog Neurol Psychiatry. 2016;20(5):11–2.CrossRefGoogle Scholar
  5. Ala T, Hughes LF, Kyrouac GA, Ghobrial MW, Elble RJ. The Mini-Mental State exam may help in the differentiation of dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2002;17:503–9.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Ali R, Barborie A, Larner AJ, White RP. Psychiatric presentation of sporadic Creutzfeldt-Jakob disease: a challenge to current diagnostic criteria. J Neuropsychiatry Clin Neurosci. 2013;25:335–8.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Allison RS. The senile brain. A clinical study. London: Edward Arnold; 1962.Google Scholar
  8. Banerjee S, Willis R, Matthews D, Contell F, Chan J, Murray J. Improving the quality of care for mild to moderate dementia: an evaluation of the Croydon Memory Service Model. Int J Geriatr Psychiatry. 2007;22:782–8.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Belmin J, Pariel-Madjlessi S, Surun P, Bentot C, Feteanu D, Lefebvre des Noettes V, et al. The cognitive disorders examination (Codex) is a reliable 3-minute test for detection of dementia in the elderly (validation study in 323 subjects). Presse Med. 2007;36:1183–90.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Bier JC, Ventura M, Donckels V, et al. Is the Addenbrooke’s Cognitive Examination effective to detect frontotemporal dementia? J Neurol. 2004;251:428–31.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Bonello M, Larner AJ, Marson AG, et al. Profound amnesia after temporal lobectomy: an autoimmune process resembling patient H.M.? Case Rep Neurol. 2014;6:251–5.PubMedCentralCrossRefPubMedGoogle Scholar
  12. Bowie P, Branton T, Holmes J. Should the Mini Mental State Examination be used to monitor dementia treatments? Lancet. 1999;354:1527–8.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Brooke P, Bullock R. Validation of a 6 item cognitive impairment test with a view to primary care usage. Int J Geriatr Psychiatry. 1999;14:936–40.PubMedCentralCrossRefPubMedGoogle Scholar
  14. Brown J. The use and misuse of short cognitive tests in the diagnosis of dementia. J Neurol Neurosurg Psychiatry. 2015;86:680–5.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Brown JM. TYM (Test Your Memory) testing. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 209–29.CrossRefGoogle Scholar
  16. Brown J, Pengas G, Dawson K, Brown LA, Clatworthy P. Self administered cognitive screening test (TYM) for detection of Alzheimer’s disease: cross sectional study. BMJ. 2009;338:b2030.PubMedCentralCrossRefPubMedGoogle Scholar
  17. Brown J, Wiggins J, Dong H, Harvey R, Richardson F, Dawson K, Parker RA. The H-TYM. Evaluation of a short cognitive test to detect mild AD and amnestic MCI. Int J Geriatr Psychiatry. 2014;29:272–80.CrossRefPubMedPubMedCentralGoogle Scholar
  18. Brown JM, Lansdall CJ, Wiggins J, et al. The Test Your Memory for Mild Cognitive Impairment (TYM-MCI). J Neurol Neurosurg Psychiatry. 2017;88:1045–51.PubMedCentralCrossRefPubMedGoogle Scholar
  19. Brugnolo A, Nobili F, Barbieri MP, et al. The factorial structure of the mini mental state examination (MMSE) in Alzheimer’s disease. Arch Gerontol Geriatr. 2009;49:180–5.CrossRefPubMedPubMedCentralGoogle Scholar
  20. Burkhardt H, Karaminejad E, Gladisch R. A short performance test can help to predict adherence to self-administration of insulin in elderly patients with diabetes. Age Ageing. 2006;35:449–50.CrossRefPubMedPubMedCentralGoogle Scholar
  21. Burns A, Lawlor B, Craig S. Assessment scales in old age psychiatry. 2nd ed. London: Martin Dunitz; 2004.CrossRefGoogle Scholar
  22. Buschke H, Kuslansky G, Katz M, et al. Screening for dementia with the Memory Impairment Screen. Neurology. 1999;52:231–8.PubMedCentralCrossRefPubMedGoogle Scholar
  23. Cagliarini AM, Price HL, Livemore ST, Larner AJ. Will use of the Six-Item Cognitive Impairment Test help to close the dementia diagnosis gap? Aging Health. 2013;9:563–6.CrossRefGoogle Scholar
  24. Can SS, Gencay-Can A, Gunendi Z. Validity and reliability of the clock drawing test as a screening tool for cognitive impairment in patients with fibromyalgia. Compr Psychiatry. 2012;53:81–6.CrossRefPubMedPubMedCentralGoogle Scholar
  25. Cannon P, Larner AJ. Errors in the scoring and reporting of cognitive screening instruments administered in primary care. Neurodegener Dis Manag. 2016;6:271–6.CrossRefPubMedPubMedCentralGoogle Scholar
  26. Carnero-Pardo C. Should the Mini-Mental State Examination be retired? Neurologia. 2014;29:473–81.CrossRefPubMedPubMedCentralGoogle Scholar
  27. Carnero Pardo C, editor. Test cognitivos breves. Madrid: Ediciones SEN; 2015.Google Scholar
  28. Caslake R, Summers F, McConachie D, et al. The Mini-Mental Parkinson’s (MMP) as a cognitive screening tool in people with Parkinson’s disease. Curr Aging Sci. 2013;6:273–9.CrossRefPubMedPubMedCentralGoogle Scholar
  29. Castiglioni S, Pelati O, Zuffi M, et al. The Frontal Assessment Battery does not differentiate frontotemporal dementia from Alzheimer’s disease. Dement Geriatr Cogn Disord. 2006;22:125–31.CrossRefPubMedPubMedCentralGoogle Scholar
  30. Ciesielska N, Sokolowski R, Mazue E, Podhorecka M, Polak-Szabela A, Kedziora-Kornatowska K. Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis. Psychiatr Pol. 2016;50:1039–52.CrossRefPubMedPubMedCentralGoogle Scholar
  31. Connon P, Larner AJ. Fragile X-associated tremor/ataxia syndrome: cognitive presentations. Br J Hosp Med. 2017a;78:230–1.CrossRefGoogle Scholar
  32. Connon P, Larner AJ. Six-item Cognitive Impairment Test (6CIT): diagnostic test accuracy study in primary care referrals. Int J Geriatr Psychiatry. 2017b;32:583–4.CrossRefPubMedPubMedCentralGoogle Scholar
  33. Copeland JR, Davidson IA, Dewey ME, et al. Alzheimer’s disease, other dementias, depression and pseudodementia: prevalence, incidence and three-year outcome in Liverpool. Br J Psychiatry. 1992;161:230–9.CrossRefPubMedPubMedCentralGoogle Scholar
  34. Copeland JR, McCracken CF, Dewey ME, Wilson KC, Doran M, Gilmore C, Scott A, Larkin BA. Undifferentiated dementia, Alzheimer’s disease and vascular dementia: age- and gender-related incidence in Liverpool. The MRC-ALPHA study. Br J Psychiatry. 1999;175:433–8.PubMedCentralCrossRefPubMedGoogle Scholar
  35. Cox C, Larner AJ. Recurrent hypoglycaemia and cognitive impairment: a 14-year follow-up. Br J Hosp Med. 2016;77:540–1.CrossRefGoogle Scholar
  36. Crawford S, Whitnall L, Robertson J, Evans JJ. A systematic review of the accuracy and clinical utility of the Addenbrooke’s Cognitive Examination and the Addenbrooke’s Cognitive Examination-Revised in the diagnosis of dementia. Int J Geriatr Psychiatry. 2012;27:659–69.CrossRefPubMedPubMedCentralGoogle Scholar
  37. Crum RM, Anthony JC, Bassett SS, Folstein MF. Population-based norms for the Mini-Mental State Examination by age and educational level. JAMA. 1993;269:2386–91.CrossRefPubMedPubMedCentralGoogle Scholar
  38. Cullen B, O’Neill B, Evans JJ, Coen RF, Lawlor BA. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatry. 2007;78:790–9.CrossRefPubMedPubMedCentralGoogle Scholar
  39. Davey RJ, Jamieson S. The validity of using the mini mental state examination in NICE dementia guidelines. J Neurol Neurosurg Psychiatry. 2004;75:343–4.PubMedCentralCrossRefPubMedGoogle Scholar
  40. Davies RR, Dawson K, Mioshi E, Erzinclioglu S, Hodges JR. Differentiation of semantic dementia and Alzheimer’s disease using the Addenbrooke’s Cognitive Examination (ACE). Int J Geriatr Psychiatry. 2008;23:370–5.CrossRefPubMedPubMedCentralGoogle Scholar
  41. Delaney BC, Hyde CJ, McManus RJ, et al. Systematic review of near patient test evaluations in primary care. BMJ. 1999;319:824–7.PubMedCentralCrossRefPubMedGoogle Scholar
  42. Dick JPR, Guiloff RJ, Stewart A, et al. Mini-mental state examination in neurological patients. J Neurol Neurosurg Psychiatry. 1984;47:496–9.PubMedCentralCrossRefPubMedGoogle Scholar
  43. Doran M, Larner AJ. EEG findings in dementia with Lewy bodies causing diagnostic confusion with sporadic Creutzfeldt-Jakob disease. Eur J Neurol. 2004;11:838–41.CrossRefPubMedPubMedCentralGoogle Scholar
  44. Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a Frontal Assessment Battery at bedside. Neurology. 2000;55:1621–6.CrossRefPubMedPubMedCentralGoogle Scholar
  45. Dubois B, Touchon J, Portet F, Ousset PJ, Vellas B, Michel B. “The 5 words”: a simple and sensitive test for the diagnosis of Alzheimer’s disease [in French]. Presse Med. 2002;31:1696–9.PubMedGoogle Scholar
  46. Dudas RB, Berrios GE, Hodges JR. The Addenbrooke’s Cognitive Examination (ACE) in the differential diagnosis of early dementias versus affective disorder. Am J Geriatr Psychiatry. 2005;13:218–26.CrossRefPubMedPubMedCentralGoogle Scholar
  47. Duff Canning SJ, Leach L, Stuss D, Ngo L, Black SE. Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia. Neurology. 2004;62:556–62.CrossRefGoogle Scholar
  48. Ellis RJ, Mbizvo GK, Jacob A, Doran M, Larner AJ. Relapsing polychondritis complicated by cognitive dysfunction: two distinct clinical phenotypes? Int J Neurosci. 2017;127:124–34.CrossRefPubMedPubMedCentralGoogle Scholar
  49. Feher EP, Mahurin RK, Doody RS, Cooke N, Sims J, Pirozzolo FJ. Establishing the limits of the Mini-Mental State Examination. Arch Neurol. 1992;49:87–92.CrossRefPubMedPubMedCentralGoogle Scholar
  50. Ferran J, Wilson K, Doran M, Ghadiali E, Johnson F, Cooper P, McCracken C. The early onset dementias: a study of clinical characteristics and service use. Int J Geriatr Psychiatry. 1996;11:863–9.CrossRefGoogle Scholar
  51. Fisher CAH, Larner AJ. Frequency and diagnostic utility of cognitive test instrument use by general practitioners prior to memory clinic referral. Fam Pract. 2007;24:495–7.PubMedCentralCrossRefPubMedGoogle Scholar
  52. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.PubMedCentralCrossRefPubMedGoogle Scholar
  53. Freedman M, Leach L, Kaplan E, Winocur G, Shulman K, Delis DC. Clock drawing. A neuropsychological analysis. New York: Oxford University Press; 1994.Google Scholar
  54. Galasko D, Klauber MR, Hofstetter CR, Salmon DP, Lasker B, Thal LJ. The Mini-Mental State Examination in the early diagnosis of Alzheimer’s disease. Arch Neurol. 1990;47:49–52.CrossRefPubMedPubMedCentralGoogle Scholar
  55. Gale TM, Larner AJ. Six-Item Cognitive Impairment Test (6CIT). In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 241–53.CrossRefGoogle Scholar
  56. Galvin JE, Roe CM, Powlishta KK, et al. The AD8. A brief informant interview to detect dementia. Neurology. 2005;65:559–64.CrossRefPubMedPubMedCentralGoogle Scholar
  57. Ganguli M, Ratcliff G, Huff FJ, et al. Serial sevens versus world backwards: a comparison of the two measures of attention from the MMSE. J Geriatr Psychiatry Neurol. 1990;3:203–7.PubMedGoogle Scholar
  58. Ghadiri-Sani M, Larner AJ. Cognitive screening instrument use in primary care: is it changing? Clin Pract. 2014;11:425–9.CrossRefGoogle Scholar
  59. Golding E. The Middlesex Elderly Assessment of Mental State. Bury St Edmunds: Thames Valley Test Company; 1989.Google Scholar
  60. Grober E, Buschke H. Genuine memory deficits in dementia. Dev Neuropsychol. 1987;3:13–36.CrossRefGoogle Scholar
  61. Han L, Cole M, Bellevance F, McCusker J, Primeau F. Tracking cognitive decline in Alzheimer’s disease using the Mini-Mental State Examination: a meta-analysis. Int Psychogeriatr. 2000;12:231–47.CrossRefPubMedPubMedCentralGoogle Scholar
  62. Hancock P, Larner AJ. The diagnosis of dementia: diagnostic accuracy of an instrument measuring activities of daily living in a clinic-based population. Dement Geriatr Cogn Disord. 2007;23:133–9.PubMedCentralCrossRefPubMedGoogle Scholar
  63. Hancock P, Larner AJ. Diagnostic utility of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and its combination with the Addenbrooke’s Cognitive Examination-Revised (ACE-R) in a memory clinic-based population. Int Psychogeriatr. 2009;21:526–30.CrossRefPubMedPubMedCentralGoogle Scholar
  64. Hancock P, Larner AJ. Test Your Memory (TYM) test: diagnostic utility in a memory clinic population. Int J Geriatr Psychiatry. 2011;26:976–80.CrossRefPubMedPubMedCentralGoogle Scholar
  65. Hancock P, Larner AJ. Cornell Scale for Depression in Dementia: clinical utility in a memory clinic. Int J Psychiatry Clin Pract. 2015;19:71–4.CrossRefPubMedPubMedCentralGoogle Scholar
  66. Hancock P, Wike J, Larner AJ. Clinical experience with CANTAB-PAL in the diagnosis of Alzheimer’s disease. Poster presentation, 17th Alzheimer Europe Conference, Estoril, Portugal, 9–11 May 2007.Google Scholar
  67. Hatfield CF, Dudas RB, Dening T. Diagnostic tools for dementia. Maturitas. 2009;63:181–5.CrossRefPubMedPubMedCentralGoogle Scholar
  68. Healey E. Elizabeth is missing. London: Penguin; 2015.Google Scholar
  69. Hennerici MG, Daffertshofer M, Caplan LR, Szabo K. Case studies in stroke. Common and uncommon presentations. Cambridge: Cambridge University Press; 2006.CrossRefGoogle Scholar
  70. Henry JD, Crawford JR, Phillips LH. Verbal fluency performance in dementia of the Alzheimer type: a meta-analysis. Neuropsychologia. 2004;42:1212–22.CrossRefPubMedPubMedCentralGoogle Scholar
  71. Hessler J, Bronner M, Etgen T, et al. Suitability of the 6CIT as a screening test for dementia in primary care patients. Aging Ment Health. 2014;18:515–20.CrossRefPubMedPubMedCentralGoogle Scholar
  72. Hodges JR, Larner AJ. Addenbrooke’s Cognitive Examinations: ACE, ACE-R, ACE-III, ACEapp, and M-ACE. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 109–37.CrossRefGoogle Scholar
  73. Hodges JR, Patterson K, Ward R, et al. The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer’s disease: a comparative neuropsychological study. Neuropsychology. 1999;13:31–40.CrossRefPubMedPubMedCentralGoogle Scholar
  74. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967;17:427–42.CrossRefPubMedPubMedCentralGoogle Scholar
  75. Holmes C, Lovestone S. Long-term cognitive and functional decline in late onset Alzheimer’s disease: therapeutic implications. Age Ageing. 2003;32:200–4.CrossRefPubMedPubMedCentralGoogle Scholar
  76. Hsieh S, Schubert S, Hoon C, Mioshi E, Hodges JR. Validation of the Addenbrooke’s Cognitive Examination III in frontotemporal dementia and Alzheimer’s disease. Dement Geriatr Cogn Disord. 2013;36:242–50.CrossRefPubMedPubMedCentralGoogle Scholar
  77. Hsieh S, McGrory S, Leslie F, et al. The Mini-Addenbrooke’s Cognitive Examination: a new assessment tool for dementia. Dement Geriatr Cogn Disord. 2015;39:1–11.CrossRefPubMedPubMedCentralGoogle Scholar
  78. Ibrahim I, Young CA, Larner AJ. Fornix damage from solitary subependymal giant cell astrocytoma causing postoperative amnesic syndrome. Br J Hosp Med. 2009;70:478–9.CrossRefGoogle Scholar
  79. Ismail Z, Mulsant BH, Herrmann N, Rapoport M, Nilsson M, Shulman K. Canadian Academy of Geriatric Psychiatry survey of brief cognitive screening instruments. Can Geriatr J. 2013;16:54–60.PubMedCentralCrossRefPubMedGoogle Scholar
  80. Julayanont P, Nasreddine ZS. Montreal Cognitive Assessment (MoCA): concept and clinical review. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 139–95.CrossRefGoogle Scholar
  81. Kalbe E, Kessler J. DemTect. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 197–208.CrossRefGoogle Scholar
  82. Kalbe E, Calabrese P, Schwalen S, Kessler J. The Rapid Dementia Screening Test (RDST): a new economical tool for detecting possible patients with dementia. Dement Geriatr Cogn Disord. 2003;16:193–9.CrossRefPubMedPubMedCentralGoogle Scholar
  83. Kalbe E, Kessler J, Calabrese P, et al. DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry. 2004;19:136–43.CrossRefPubMedPubMedCentralGoogle Scholar
  84. Larner AJ. MMSE subscores and the diagnosis of dementia with Lewy bodies. Int J Geriatr Psychiatry. 2003;18:855–6.CrossRefPubMedPubMedCentralGoogle Scholar
  85. Larner AJ. Use of MMSE to differentiate Alzheimer’s disease from dementia with Lewy bodies. Int J Geriatr Psychiatry. 2004;19:1209–10.CrossRefGoogle Scholar
  86. Larner AJ. “Dementia unmasked”: atypical, acute aphasic, presentations of neurodegenerative dementing disease. Clin Neurol Neurosurg. 2005a;108:8–10.CrossRefPubMedGoogle Scholar
  87. Larner AJ. An audit of the Addenbrooke’s Cognitive Examination (ACE) in clinical practice. Int J Geriatr Psychiatry. 2005b;20:593–4.PubMedCentralCrossRefPubMedGoogle Scholar
  88. Larner AJ. An audit of the Addenbrooke’s Cognitive Examination (ACE) in clinical practice. 2. Longitudinal change. Int J Geriatr Psychiatry. 2006;21:698–9.CrossRefPubMedPubMedCentralGoogle Scholar
  89. Larner AJ. Of clocks and mirrors: the Backward Clock Test. Eur J Neurol. 2007a;14(Suppl 1):100. (abstract P1265)Google Scholar
  90. Larner AJ. Addenbrooke’s Cognitive Examination (ACE) for the diagnosis and differential diagnosis of dementia. Clin Neurol Neurosurg. 2007b;109:491–4.PubMedCentralCrossRefPubMedGoogle Scholar
  91. Larner AJ. Addenbrooke’s Cognitive Examination-Revised (ACE-R) in day-to-day clinical practice. Age Ageing. 2007c;36:685–6.CrossRefPubMedPubMedCentralGoogle Scholar
  92. Larner AJ. DemTect in the diagnosis of dementia: first 100 patients. In: Iqbal K, Winblad B, Avila J, editors. Alzheimer’s disease: new advances. Collection of selected articles of papers presented at the 10th International Conference on Alzheimer’s disease and related disorders. Madrid, Spain, July 15–20, 2006. Medimond: Bologna; 2007d. p. 177–81.Google Scholar
  93. Larner AJ. DemTect: 1-year experience of a neuropsychological screening test for dementia. Age Ageing. 2007e;36:326–7.PubMedCentralCrossRefPubMedGoogle Scholar
  94. Larner AJ. Addenbrooke’s Cognitive Examination-Revised in day-to-day clinical practice. Reply. Age Ageing. 2008a;37:350–1.CrossRefGoogle Scholar
  95. Larner AJ. Cambridge Behavioural Inventory: diagnostic and differential diagnostic utility. J Neurol Neurosurg Psychiatry. 2008b;79:351–2. (abstract 61)Google Scholar
  96. Larner AJ. ACE-R: cross-sectional and longitudinal use for cognitive assessment. In: Fisher A, Hanin I, editors. New trends in Alzheimer and Parkinson related disorders: ADPD 2009. Collection of selected free papers from the 9th International Conference on Alzheimer’s and Parkinson’s disease AD/PD. Prague, Czech Republic, March 11–15, 2009. Bologna: Medimond International Proceedings; 2009a. p. 103–7.Google Scholar
  97. Larner AJ. Addenbrooke’s Cognitive Examination-Revised: cross-sectional and longitudinal use for cognitive assessment. Neurodegener Dis. 2009b;6(Suppl 1):194.Google Scholar
  98. Larner AJ. Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutation. J Neurol Sci. 2009c;287:253–6.PubMedCentralCrossRefPubMedGoogle Scholar
  99. Larner AJ. Is Mini-Mental Parkinson (MMP) a useful screening test in a cognitive clinic population? Eur J Neurol. 2010;17(Suppl 3):205. (abstract P1342)Google Scholar
  100. Larner AJ. Frontal Assessment Battery (FAB): a pragmatic study. Neurodegener Dis. 2011;8(Suppl 1):565.Google Scholar
  101. Larner AJ. Screening utility of the Montreal Cognitive Assessment (MoCA): in place of—or as well as—the MMSE? Int Psychogeriatr. 2012a;24:391–6.PubMedCentralCrossRefPubMedGoogle Scholar
  102. Larner AJ. Mini-Mental Parkinson (MMP) as a dementia screening test: comparison with the Mini-Mental State Examination (MMSE). Curr Aging Sci. 2012b;5:136–9.CrossRefPubMedPubMedCentralGoogle Scholar
  103. Larner AJ. FTDP-17: 2-year follow-up of motor and cognitive features after autologous stem-cell transplantation. J Neuropsychiatry Clin Neurosci. 2012c;24(2):E1–2.CrossRefPubMedPubMedCentralGoogle Scholar
  104. Larner AJ, editor. Cognitive screening instruments. A practical approach. London: Springer; 2013a.Google Scholar
  105. Larner AJ. Addenbrooke’s Cognitive Examination-Revised (ACE-R): pragmatic study of cross-sectional use for assessment of cognitive complaints of unknown aetiology. Int J Geriatr Psychiatry. 2013b;28:547–8.PubMedCentralCrossRefPubMedGoogle Scholar
  106. Larner AJ. Codex (cognitive disorders examination) for the detection of dementia and mild cognitive impairment. Codex pour la détection de la démence et du mild cognitive impairment. Presse Med. 2013c;42:e425–8.CrossRefPubMedPubMedCentralGoogle Scholar
  107. Larner AJ. Addenbrooke’s Cognitive Examination standardized verbal fluency scores for differential diagnosis of AD and FTLD. J Neurol Sci. 2013d;333:e292.CrossRefGoogle Scholar
  108. Larner AJ. Can the Frontal Assessment Battery (FAB) help in the diagnosis of behavioural variant frontotemporal dementia? A pragmatic study. Int J Geriatr Psychiatry. 2013e;28:106–7.CrossRefPubMedPubMedCentralGoogle Scholar
  109. Larner AJ. AD8 informant questionnaire for cognitive impairment: pragmatic diagnostic test accuracy study. J Geriatr Psychiatry Neurol. 2015a;28:198–202.CrossRefPubMedPubMedCentralGoogle Scholar
  110. Larner AJ. Mini-Addenbrooke’s Cognitive Examination: a pragmatic diagnostic accuracy study. Int J Geriatr Psychiatry. 2015b;30:547–8.CrossRefPubMedPubMedCentralGoogle Scholar
  111. Larner AJ. Mini-Addenbrooke’s Cognitive Examination diagnostic accuracy for dementia: reproducibility study. Int J Geriatr Psychiatry. 2015c;30:1103–4.CrossRefPubMedPubMedCentralGoogle Scholar
  112. Larner AJ. Optimizing the cutoffs of cognitive screening instruments in pragmatic diagnostic accuracy studies: maximising accuracy or Youden index? Dement Geriatr Cogn Disord. 2015d;39:167–75.CrossRefPubMedPubMedCentralGoogle Scholar
  113. Larner AJ. Implications of changing the Six-item Cognitive Impairment Test cutoff. Int J Geriatr Psychiatry. 2015e;30:778–9.CrossRefPubMedPubMedCentralGoogle Scholar
  114. Larner AJ. Six Item Cognitive Impairment Test: suitable for the visually impaired? Prog Neurol Psychiatry. 2015f;19(6):20–2.CrossRefGoogle Scholar
  115. Larner AJ. Hard-TYM: a pragmatic study. Int J Geriatr Psychiatry. 2015g;30:330–1.CrossRefPubMedPubMedCentralGoogle Scholar
  116. Larner AJ. Cognitive screening instruments for the diagnosis of mild cognitive impairment. Prog Neurol Psychiatry. 2016a;20(2):21–6.CrossRefGoogle Scholar
  117. Larner AJ. Correlation or limits of agreement? Applying the Bland-Altman approach to the comparison of cognitive screening instruments. Dement Geriatr Cogn Disord. 2016b;42:247–54.CrossRefPubMedPubMedCentralGoogle Scholar
  118. Larner AJ. M-ACE vs. MoCA: a weighted comparison. Int J Geriatr Psychiatry. 2016c;31:1089–90.CrossRefPubMedPubMedCentralGoogle Scholar
  119. Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017a.Google Scholar
  120. Larner AJ. Introduction to cognitive screening instruments: rationale and desiderata. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017b. p. 3–13.CrossRefGoogle Scholar
  121. Larner AJ. MMSE variants and subscores. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017c. p. 49–66.CrossRefGoogle Scholar
  122. Larner AJ. MACE versus MoCA: equivalence or superiority? Pragmatic diagnostic test accuracy study. Int Psychogeriatr. 2017d;29:931–7.CrossRefPubMedPubMedCentralGoogle Scholar
  123. Larner AJ. Short Montreal Cognitive Assessment: validation and reproducibility. J Geriatr Psychiatry Neurol. 2017e;30:104–8.CrossRefPubMedPubMedCentralGoogle Scholar
  124. Larner AJ. The usage of cognitive screening instruments: test characteristics and suspected diagnosis. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017f. p. 315–39.CrossRefGoogle Scholar
  125. Larner AJ. FRONTIER Executive Screen (FES). Poster P0034, Association of British Neurologists annual meeting, Liverpool, 3–5 May 2017g.Google Scholar
  126. Larner AJ. Assessment of cognitive function. In: Severn A, editor. Cognitive changes after surgery. London: Springer; 2018a.Google Scholar
  127. Larner AJ. Metamemory: a construct with diagnostic utility in a cognitive disorders clinic? Int J Geriatr Psychiatry. 2018b;33:553–4.PubMedCentralCrossRefPubMedGoogle Scholar
  128. Larner AJ, Bracewell RM. A new FRONTIER in dementia differential diagnosis? J R Coll Physicians Edinb. 2016;46:172–3.CrossRefPubMedPubMedCentralGoogle Scholar
  129. Larner AJ, Doran M. Broader assessment needed for treatment decisions in AD. Prog Neurol Psychiatry. 2002;6(3):5–6.Google Scholar
  130. Larner AJ, Hancock P. Does combining cognitive and functional scales facilitate the diagnosis of dementia? Int J Geriatr Psychiatry. 2012;27:547–8.CrossRefPubMedPubMedCentralGoogle Scholar
  131. Larner AJ, Hancock P. ACE-R or MMSE? A weighted comparison. Int J Geriatr Psychiatry. 2014;29:767–8.CrossRefPubMedPubMedCentralGoogle Scholar
  132. Larner AJ, Mitchell AJ. A meta-analysis of the accuracy of the Addenbrooke’s Cognitive Examination (ACE) and the Addenbrooke’s Cognitive Examination-Revised (ACE-R) in the detection of dementia. Int Psychogeriatr. 2014;26:555–63.CrossRefPubMedPubMedCentralGoogle Scholar
  133. Larner AJ, Young CA. Acute amnesia in multiple sclerosis revisited. Int MS J. 2009;16:102–4.PubMedGoogle Scholar
  134. Larner AJ, Moffat MA, Ghadiali E, Majid S, English P, Williams G. Amnesia following profound hypoglycaemia in a type 1 diabetic patient. Eur J Neurol. 2003a;10(Suppl 1):92. (abstract P1170)Google Scholar
  135. Larner AJ, Downes JJ, Hanley JR, Tsivilis D, Doran M. Developmental prosopagnosia: a clinical and neuropsychological study. J Neurol. 2003b;250(Suppl 2):II156. (abstract P591)Google Scholar
  136. Larner AJ, Ray PS, Doran M. The R269H mutation in presenilin-1 presenting as late-onset autosomal dominant Alzheimer’s disease. J Neurol Sci. 2007;252:173–6.CrossRefPubMedPubMedCentralGoogle Scholar
  137. Law E, Connelly PJ, Randall E, et al. Does the Addenbrooke’s Cognitive Examination-revised add to the Mini-Mental State Examination in established Alzheimer disease? Results from a national dementia research register. Int J Geriatr Psychiatry. 2013;28:351–5.CrossRefPubMedPubMedCentralGoogle Scholar
  138. Leslie FVC, Foxe D, Daveson N, Flannagan E, Hodges JR, Piguet O. FRONTIER Executive Screen: a brief executive battery to differentiate frontotemporal dementia and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2016;87:831–5.CrossRefPubMedPubMedCentralGoogle Scholar
  139. Levin P, editor. The Penguin book of the sonnet. 500 years of a classic tradition in English. London: Penguin; 2001.Google Scholar
  140. Lezak MD, Howieson DB, Bigler ED, Tranel D. Neuropsychological assessment. 5th ed. New York: Oxford University Press; 2012.Google Scholar
  141. Lindeboom J, Schmand B, Tulner L, Walstra G, Jonker C. Visual association test to detect early dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry. 2002;73:126–33.PubMedCentralCrossRefPubMedGoogle Scholar
  142. Lipton AM, Ohman KA, Womack KB, Hynan LS, Ninman ET, Lacritz LH. Subscores of the FAB differentiate frontotemporal lobar degeneration from AD. Neurology. 2005;65:726–31.CrossRefPubMedPubMedCentralGoogle Scholar
  143. Lozsadi DA, Larner AJ. Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer’s disease. Dement Geriatr Cogn Disord. 2006;22:121–4.CrossRefPubMedGoogle Scholar
  144. Magni E, Binetti G, Padovani A, Cappa SF, Bianchetti A, Trabucchi M. The Mini-Mental State Examination in Alzheimer’s disease and multi-infarct dementia. Int Psychogeriatr. 1996;8:127–34.CrossRefPubMedPubMedCentralGoogle Scholar
  145. Mahieux F, Michelet D, Manifacier M-J, Boller F, Fermanian J, Guillard A. Mini-Mental Parkinson: first validation study of a new bedside test constructed for Parkinson’s disease. Behav Neurol. 1995;8:15–22.CrossRefPubMedPubMedCentralGoogle Scholar
  146. Mainland BJ, Shulman KI. Clock Drawing Test. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 67–108.CrossRefGoogle Scholar
  147. Malloy PF, Cummings JL, Coffey CE, et al. Cognitive screening instruments in neuropsychiatry: a report of the Committee on Research of the American Neuropsychiatric Association. J Neuropsychiatry Clin Neurosci. 1997;9:189–97.CrossRefPubMedPubMedCentralGoogle Scholar
  148. Maruta C, Guerreiro M, de Mendonca A, Hort J, Scheltens P. The use of neuropsychological tests across Europe: the need for a consensus in the use of assessment tools for dementia. Eur J Neurol. 2011;18:279–85.CrossRefPubMedPubMedCentralGoogle Scholar
  149. Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer’s disease and frontotemporal dementia. Neurology. 2000;55:1613–20.CrossRefPubMedPubMedCentralGoogle Scholar
  150. McCormick LJ, Larner AJ. “Could you repeat that?”: Not always a hearing problem! Br J Hosp Med. 2018;79. (in press)Google Scholar
  151. McDicken JA, Blayney G, Elliott E, Makin S, Ali M, Larner AJ. Quinn TJ. Accuracy of the short form Montreal Cognitive Assessment: systematic review and external validation; 2018. (submitted).Google Scholar
  152. Menon R, Larner AJ. Use of cognitive screening instruments in primary care: the impact of national dementia directives (NICE/SCIE, National Dementia Strategy). Fam Pract. 2011;28:272–6.PubMedCentralCrossRefPubMedGoogle Scholar
  153. Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The Addenbrooke’s Cognitive Examination Revised: a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006;21:1078–85.CrossRefPubMedPubMedCentralGoogle Scholar
  154. Mitchell AJ. The Mini-Mental State Examination (MMSE): update on its diagnostic accuracy and clinical utility for cognitive disorders. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 37–48.CrossRefGoogle Scholar
  155. Mitchell AJ, Malladi S. Screening and case-finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests. Am J Geriatr Psychiatry. 2010a;18:759–82.CrossRefPubMedPubMedCentralGoogle Scholar
  156. Mitchell AJ, Malladi S. Screening and case-finding tools for the detection of dementia. Part II: evidence-based meta-analysis of single-domain tests. Am J Geriatr Psychiatry. 2010b;18:783–800.CrossRefPubMedPubMedCentralGoogle Scholar
  157. Mitrushina M, Boone KB, Razani J, D’Elia LF. Handbook of normative data for neuropsychological assessment. 2nd ed. Oxford: Oxford University Press; 2005.Google Scholar
  158. Möller WD, Vetter P, Sprenger S, Kropp P. Importance of tests for diagnosing dementia. Eur J Neurol. 2009;16(Suppl3):368. (abstract P2090)Google Scholar
  159. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.CrossRefPubMedPubMedCentralGoogle Scholar
  160. National Institute for Clinical Excellence. Guidance on the use of donepezil, rivastigmine, and galantamine for the treatment of Alzheimer’s disease (Technology Appraisal Guidance No. 19). London: NICE; 2001.Google Scholar
  161. Newman CGJ, Bevins AD, Zajicek JP, et al. Improving the quality of cognitive screening assessments: ACEmobile, an iPad-based version of the Addenbrooke’s Cognitive Examination-III. Alzheimers Dement (Amst). 2017;10:182–7.Google Scholar
  162. Newman JC, Feldman R. Copyright and open access at the bedside. N Engl J Med. 2011;365:2447–9.CrossRefPubMedPubMedCentralGoogle Scholar
  163. Nieuwenhuis-Mark RE. The death knoll for the MMSE: has it outlived its purpose? J Geriatr Psychiatry Neurol. 2010;23:151–7.CrossRefPubMedPubMedCentralGoogle Scholar
  164. Olazaran J, Hoyos-Alonso MC, del Ser T, et al. Practical application of brief cognitive tests. Neurologia. 2016;31:183–94.CrossRefPubMedPubMedCentralGoogle Scholar
  165. Papageorgiou S, Nikaki M, Kontaxis T, et al. Can the frontal assessment battery differentiate between frontotemporal dementia (FTD) and Alzheimer’s disease (AD)? Eur J Neurol. 2009;16(Suppl 3):442. (abstract P2317)Google Scholar
  166. Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352:2379–88.CrossRefPubMedPubMedCentralGoogle Scholar
  167. Poppelreuter W (Zihl J, Weiskrantz L, transl.). Disturbances of lower and higher visual capacities caused by occipital damage with special reference to the psychopathological, pedagogical, industrial, and social implications. Oxford: Clarendon Press; 1917a.Google Scholar
  168. Poppelreuter W. Die psychischen Schädigungen durch Kopfschuss im Kriege 1914/17: mit besonderer Berücksichtigung der pathopsychologischen, pädagogischen, gewerblichen und sozialen Beziehungen (2 volumes: Band 1: Die Störungen der niederen und höheren Sehleistungen durch Verletzungen des Okzipitalhirns; Band 2: Die Herabsetzung der körperlichen Leistungsfähigkeit und des Arbeitswillens durch Hirnverletzung im Vergleich zu Normalen und Psychogenen). Leipzig: Voss; 1917b–1918.Google Scholar
  169. Randolph C, Tierney MC, Mohr E, Chase TN. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998;20:310–9.CrossRefPubMedPubMedCentralGoogle Scholar
  170. Rawle MJ, Larner AJ. NARP syndrome: a 20-year follow-up. Case Rep Neurol. 2013;5:204–7.PubMedCentralCrossRefPubMedGoogle Scholar
  171. Rawle M, Larner A. MoCA subscores to diagnose dementia subtypes: initial study. J Neurol Neursurg Psychiatry. 2014;85:e4.CrossRefGoogle Scholar
  172. Ridha B, Rossor M. How to do it. The Mini Mental State Examination. Pract Neurol. 2005;5:298–303.CrossRefGoogle Scholar
  173. Roalf DR, Moore TM, Wolk DA, et al. Defining and validating a short form Montreal Cognitive Assessment (s-MoCA) for use in neurodegenerative disease. J Neurol Neurosurg Psychiatry. 2016;87:1303–10.PubMedCentralCrossRefPubMedGoogle Scholar
  174. Scheurich A, Muller MJ, Slessmeier T, et al. Validating the DemTect with 18-fluoro-2-deoxy-glucose positron emission tomography as a sensitive neuropsychological screening test for early Alzheimer disease in patients of a memory clinic. Dement Geriatr Cogn Disord. 2005;20:271–7.CrossRefPubMedPubMedCentralGoogle Scholar
  175. Sells R, Larner AJ. The Poppelreuter figure visual perceptual function test for dementia diagnosis. Prog Neurol Psychiatry. 2011;15(2):17–8, 20–1.CrossRefGoogle Scholar
  176. Seshadri M, Mazi-Kotwal N. A copyright-free alternative is needed. BMJ. 2012;345:e8589.CrossRefPubMedPubMedCentralGoogle Scholar
  177. Slachevsky A, Villalpando JM, Sarazin M, Hahn BV, Pillon B, Dubois B. Frontal assessment battery and differential diagnosis of frontotemporal dementia and Alzheimer disease. Arch Neurol. 2004;61:1104–7.CrossRefPubMedPubMedCentralGoogle Scholar
  178. Smithson E, Larner AJ. Glioblastoma multiforme masquerading as herpes simplex encephalitis. Br J Hosp Med. 2013;74:52–3.CrossRefGoogle Scholar
  179. St John L, Larner AJ. Muscle wasting, bone pain and cognitive decline: a unifying diagnosis. Br J Hosp Med. 2015;76:602–3.CrossRefGoogle Scholar
  180. Stagg B, Larner AJ. Zarit Burden Interview: pragmatic study in a dedicated cognitive function clinic. Prog Neurol Psychiatry. 2015;19(4):23–7.CrossRefGoogle Scholar
  181. Storton K, Larner AJ. Montreal Cognitive Assessment (MoCA): diagnostic utility in a cognitive clinic population. Alzheimers Dement. 2011;7(Suppl1):S166. (abstract P1–171)Google Scholar
  182. Strauss E, Sherman EMS, Spreen O. A compendium of neuropsychological tests: administration, norms, and commentary. 3rd ed. New York: Oxford University Press; 2006.Google Scholar
  183. Tangalos EG, Smith GE, Ivnik RJ, et al. The Mini-Mental State Examination in general medical practice: clinical utility and acceptance. Mayo Clin Proc. 1996;71:829–37.CrossRefPubMedPubMedCentralGoogle Scholar
  184. Tate RL. A compendium of tests, scales, and questionnaires. The practitioner’s guide to measuring outcomes after acquired brain impairment. Hove: Psychology Press; 2010.Google Scholar
  185. Tombaugh TN, McIntyre NJ. The Mini-Mental State Examination: a comprehensive review. J Am Geriatr Soc. 1992;40:922–35.CrossRefPubMedPubMedCentralGoogle Scholar
  186. Tsoi KK, Chan JY, Hirai HW, Wong SY, Kwok TC. Cognitive tests to detect dementia. A systematic review and meta-analysis. JAMA Intern Med. 2015;175:1450–8.CrossRefPubMedPubMedCentralGoogle Scholar
  187. Valcour VG, Masaki KH, Blanchette PL. The phrase: “no ifs, ands, or buts” and cognitive testing. Lessons from an Asian-American community. Hawaii Med J. 2002;61:72–4.PubMedGoogle Scholar
  188. Werner P, Heinik J, Lin R, Bleich A. “Yes” ifs, ands or buts: examining performance and correlates of the repetition task in the mini-mental state examination. Int J Geriatr Psychiatry. 1999;14:719–25.CrossRefPubMedPubMedCentralGoogle Scholar
  189. Williamson J, Larner AJ. Fibromyalgia: cognitive aspects. Br J Hosp Med. 2016;77:116.CrossRefGoogle Scholar
  190. Williamson J, Larner AJ. MACE for diagnosis of dementia and MCI: 3-year pragmatic diagnostic test accuracy study. Dement Geriatr Cogn Disord. 2018;45. (in press)Google Scholar
  191. Wilson M, Doran M, Enevoldson TP, Larner AJ. Cognitive profiles associated with intracranial dural arteriovenous fistula. Age Ageing. 2010;39:389–92.CrossRefPubMedPubMedCentralGoogle Scholar
  192. Wojtowicz A, Larner AJ. General Practitioner Assessment of Cognition: use in primary care prior to memory clinic referral. Neurodegener Dis Manag. 2015;5:505–10.CrossRefPubMedPubMedCentralGoogle Scholar
  193. Wojtowicz A, Larner A. Scoring errors in cognitive screening instruments administered in primary care. J Neurol Neurosurg Psychiatry. 2016;87:e1.CrossRefGoogle Scholar
  194. Wojtowicz A, Schott JM, Larner AJ. CSF biomarkers and the diagnosis of variant forms of Alzheimer’s disease. Prog Neurol Psychiatry. 2017;21(2):13–5.CrossRefGoogle Scholar
  195. Wong S, Hart IK, Larner AJ. Revised Addenbrooke’s Cognitive Examination in the assessment of voltage-gated potassium channel antibody-positive non-paraneoplastic limbic encephalitis. Eur J Neurol. 2008;15(Suppl 3):303. (abstract P2368)Google Scholar
  196. Wong SH, Saunders M, Larner AJ, Das K, Hart IK. An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis. J Neurol Neurosurg Psychiatry. 2010;81:1167–9.CrossRefPubMedPubMedCentralGoogle Scholar
  197. Woodford HJ, George J. Cognitive assessment in the elderly: a review of clinical methods. Q J Med. 2007;100:469–84.CrossRefGoogle Scholar
  198. Woodward M, Brodaty H, Boundy K, Ames D, Blanch G, Balshaw R. PRIME Study Group. Does executive impairment define a frontal variant of Alzheimer’s disease? Int Psychogeriatr. 2010;22:1280–90.CrossRefPubMedPubMedCentralGoogle Scholar
  199. Zaccai J, McCracken C, Brayne C. A systematic study of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing. 2005;34:561–6.CrossRefPubMedPubMedCentralGoogle Scholar
  200. Ziso B, Larner AJ. Codex (cognitive disorders examination) for the detection of dementia and mild cognitive impairment: diagnostic utility. J Neurol Neurosurg Psychiatry. 2013;84:e2.CrossRefGoogle Scholar
  201. Ziso B, Larner A. Levodopa response in paroxysmal exercise-induced dystonia without GLUT1 deficiency. Eur J Neurol. 2015;22(Suppl1):394.Google Scholar
  202. Ziso B, Larner AJ. STOP-Bang: screening for obstructive sleep apnoea in a cognitive disorders clinic. J Sleep Disord Ther. 2016;5:223.Google Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • A. J. Larner
    • 1
  1. 1.Cognitive Function ClinicWalton Centre for Neurology and NeurosurgeryLiverpoolUK

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