Traumatic Brain Lesion Quantification Based on Mean Diffusivity Changes
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We report the evaluation of an automated method for quantification of brain tissue damage, caused by a severe traumatic brain injury, using mean diffusivity computed from MR diffusion images. Our automatic results obtained on realistic phantoms and real patient images 10 days post-event provided by nine different centers were coherent with four expert manually identified lesions. For realistic phantoms automated method scores were equal to 0.77, 0.77 and 0.83 for Dice, Precision and Sensibility respectively compared to 0.78, 0.72 and 0.86 for the experts. The inter correlation class (ICC) was 0.79. For 7/9 real cases 0.57, 0.50 and 0.70 were respectively obtained for automated method compared to 0.60, 0.52 and 0.78 for experts with ICC = 0.71. Additionally, we detail the quality control module used to pool data from various image provider centers. This study clearly demonstrates the validity of the proposed automated method to eventually compute in a multi-centre project, the lesional load following brain trauma based on MD changes.
Grenoble MRI facility IRMaGe was partly funded by the French program Investissement d’avenir run by the Agence Nationale pour la Recherche; grant Infrastructure d’avenir en Biologie Santé - ANR-11-INBS-0006. Research funded by French ministry of research and education under the Projet Hospitalier de Recherche Clinique grant OXY-TC to JFP.
- 3.Doyle, S., Forbes, F., Dojat, M.: P-locus, a complete suite for brain scan segmentation. In: 9h IEEE International Symposium on Biomedical Imaging (ISBI) (2012)Google Scholar
- 4.Dubuisson, M., Jain, A.: A modified hausdorff distance for object-matching. In: 12th International Conference on Pattern Recognition (IPAR), pp. 566–568 (1994)Google Scholar
- 9.Maggia, C., Doyle, S., Forbes, F., Heck, O., Troprès, I., Berthet, C., Teyssier, Y., Velly, L., Payen, J.-F., Dojat, M.: Assessment of tissue injury in severe brain trauma. In: Crimi, A., Menze, B., Maier, O., Reyes, M., Handels, H. (eds.) BrainLes 2015. LNCS, vol. 9556, pp. 57–68. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-30858-6_6 CrossRefGoogle Scholar