Multiparametric Examination: Basic and Innovative Methods of Ultrasound in Diagnosis of Breast Cancer

  • Alexander N. Sencha
  • Yury Patrunov
  • Ekaterina Sencha
  • Ella Penyaeva
  • Valeriy Rodionov


Grayscale ultrasound (US) is the principal ultrasound imaging modality to diagnose breast diseases and breast cancer in particular. Nodular type of breast cancer (up to 80% of breast carcinoma) is characterized by the presence of a lesion within breast structure that can be revealed in grayscale mode or other US regimens. Infiltrative (diffuse) types of breast cancer usually exhibit clinically evident local signs. Ultrasound is highly sensitive (85–93%) in detection of a tumor in any clinically doubtful situation and can provide guidance for biopsy with morphological verification. Paget’s cancer is an intraductal epidermotropic eczema-like breast cancer, which originates from the ostia of large milk ducts of the nipple and involves the nipple and the areola and spreads to other parts of the breast. Assessment of the elasticity (stiffness) of tissues for early diagnosis and differentiation of malignant breast conditions is undoubtedly promising and prospective. Contrast-enhanced ultrasound (CEUS) is an informative technology for visualization of the blood flow in breast tumors and identification of neoangiogenesis, which is a characteristic for malignancy. The sensitivity of CEUS in the detection of breast cancer in women is 88%, specificity 90%, and accuracy 89%. Different classifications of breast cancer, including breast imaging-reporting and data system (BI-RADS), morphological types of tumors, and ultrasound correlations are also provided.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Alexander N. Sencha
    • 1
  • Yury Patrunov
    • 2
  • Ekaterina Sencha
    • 3
  • Ella Penyaeva
    • 2
  • Valeriy Rodionov
    • 4
  1. 1.Division of Visual DiagnosticsNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russian FederationMoscowRussia
  2. 2.Department of Ultrasound Diagnostics of Radiology CenterYaroslavl Railway ClinicYaroslavlRussia
  3. 3.Department of Ultrasound DiagnosticsFederal State Budget Hospital “9 Treatment and Diagnostic Center” of the Ministry of Defense of the Russian FederationMoscowRussia
  4. 4.Department of Breast DiseasesNational Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian FederationMoscowRussia

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