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Melanoma

  • Jennifer Divine
  • Anna S. Clayton
Chapter

Abstract

Melanoma most commonly presents as a new or changing pigmented lesion on sun exposed skin. The skin cancer can be categorized into varying subtypes based on its clinical appearance and anatomical location. The prognosis is similar amongst the subtypes with tumor thickness as the most important factor for survival. Melanoma staging depends upon the patient’s symptoms, clinical exam and clinician’s index of suspicion. Surgery is the first line treatment for localized melanoma. Advances in tumor genetics and immunology have led to the development of targeted therapies for metastatic disease.

Keywords

Invasive Melanoma Nevi Genetic mutations BRAF MAPK MEK NRAS Kit CDKN2A Risk factors UV radiation Dysplastic nevi ABCD Dermoscopy Melanoma in situ Nodular melanoma Metastatic melanoma Histology Immunohistochemistry Breslow depth Staging TNM Prognosis Survival Sentinel lymph node Wide local excision Margins Radiation therapy Chemotherapy Adjuvant therapy Immunotherapy Cytokines Cancer vaccine Oncolytic viral therapy Targeted therapy 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Jennifer Divine
    • 1
  • Anna S. Clayton
    • 2
  1. 1.Divine Dermatology and Surgical InstituteFort CollinsUSA
  2. 2.DermatologyVanderbilt University of MedicineNashvilleUSA

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