Adnexal Carcinoma: Microcystic Adnexal Carcinoma and Sebaceous Carcinoma

  • Paul R. MasseyEmail author
  • Anthony C. Soldano
  • Matthew C. Fox


Microcystic adnexal carcinoma (MAC) and sebaceous carcinoma (SC) are rare adnexal neoplasms. MAC most commonly presents as a poorly defined, firm, skin-colored papule, nodule, or plaque on the head and neck. Although locally destructive, MAC does not typically metastasize. Rates of misdiagnosis are high, due to incomplete, superficial sampling. Resection techniques with meticulous margin control, including Mohs micrographic surgery (MMS), are recommended in the management of MAC.

Sebaceous carcinoma, originating from holocrine sebocytes, is often found on the head and neck and is among the most common eyelid neoplasms. SC commonly presents as a firm, subcutaneous nodule with a yellow hue. SC may masquerade as other neoplastic and inflammatory entities, delaying diagnosis. Patients with SC must be screened for Muir-Torre syndrome, a hereditary cancer syndrome. Treatment for SC is surgical. SC has metastatic potential, most commonly to draining lymph node basins. Radiation and chemotherapy play a role in the management of metastatic disease.


Microcystic adnexal carcinoma Sebaceous carcinoma Sebaceous neoplasm Desmoplastic trichoepithelioma Morpheaform basal cell carcinoma Muir-Torre Syndrome Sentinel lymph node biopsy Mohs micrographic surgery 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Paul R. Massey
    • 1
    Email author
  • Anthony C. Soldano
    • 1
  • Matthew C. Fox
    • 1
  1. 1.Division of DermatologyDell Medical School, University of Texas at AustinAustinUSA

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