A Painful Subcutaneous Nodule

  • Rebecca S. ThornhillEmail author
  • Nicole Asher


A 68-year-old man with a remote history of squamous cell carcinoma (SCC) involving the submental area presented with a slowly growing painful 2-cm subcutaneous nodule. Low-power examination (Fig. 22.1) yielded an ill-circumscribed deep dermal/subcutaneous lesion. At intermediate power (Fig. 22.2), a dense scar is seen approximating spindled cellular areas that at high-power examination (Fig. 22.3) yielded a wavy orientation typical of nerve tissue. The nerves are infiltrated and surrounded by densely chromatic cohesive cells, and in some areas dyskeratosis can be seen. Discernible inflammation is not identified.


Perineural tumoral infiltrates Squamous cell carcinoma Peritumoral fibrosis 


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© Springer Science+Business Media LLC 2018

Authors and Affiliations

  1. 1.Greenville Health SystemUniversity of South CarolinaGreenvilleUSA
  2. 2.American University of the Caribbean School of MedicineClermontUSA

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