Lymphocytic infiltrates are near inviolate accompaniments of cutaneous dermal pathology. Lymphocytes in variant numbers can be seen in the vicinity of superficial dermal vessels and the adnexae in most biopsys specimens. Increased numbers of lymphocytes may, however, represent a pathologic condition of a diverse etiology. These entities encompass a variety of inflammatory (i.e., acne/rosacea), infections (i.e., herpes simplex virus) and neoplastic (i.e., lymphoma) conditions. Each of these diseases’ states with particular attention to its histologic presentation in the setting of frozen sections or Mohs pathology are presumed herein.