Human Papillomavirus and Head and Neck Cancer

  • Farhoud Faraji
  • Carole FakhryEmail author


Human papillomavirus (HPV) is a common sexually transmitted pathogen and the primary infectious cause of HPV-related oropharyngeal carcinoma (HPV-OPC). HPV-OPC is distinct in its pathophysiology, epidemiology, and clinical course from HPV-negative head and neck squamous cell carcinoma (HNSCC). The incidence of HPV-OPC has steadily grown over the past several decades. This rise has been attributed to sexual behaviors that increase exposure to HPV. While intensive investigation is clarifying the risk factors and treatment strategies for HPV-OPC, the natural history of carcinogenic HPV infection in HNSCC remains incompletely understood. This chapter provides an overview of carcinogenic HPV infection and the epidemiology of oral HPV infection.


Human papillomavirus HPV Oropharyngeal Head and neck Squamous cell carcinoma Oral infection Epidemiology Carcinogenesis 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Saint Louis University School of MedicineSt. LouisUSA
  2. 2.Department of Otolaryngology—Head and Neck SurgeryJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of EpidemiologyJohns Hopkins University Bloomberg School of Public HealthBaltimoreUSA

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